RNS Number:9892R
Skyepharma PLC
12 November 2003


For Immediate Release                        12 November 2003




                         SkyePharma PLC ("the Company")



                    Notification of Major Interest in Shares



In accordance with the Companies Act 1985 (as amended) the Company was informed
by Fidelity Investments on 11 November 2003 that FMR Corp and its direct and
indirect subsidiaries and Fidelity International Limited and its direct and
indirect subsidiaries, both being non-beneficial holders, had increased their
holding to 21,988,595 ordinary shares of 10p each, representing 3.56% of the
issued share capital of the Company.



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