This Amendment No. 2 (this Amendment) to Schedule 14D-9 amends and supplements the Solicitation/Recommendation Statement on Schedule 14D-9 previously filed by Lumos Pharma, Inc., a Delaware corporation (Lumos or
the Company), with the U.S. Securities and Exchange Commission (the SEC) on November 14, 2024 (as amended and supplemented on November 29, 2024, the Schedule
14D-9), with respect to the tender offer made by DPV MergerSub, Inc. (Purchaser), a Delaware corporation and a wholly owned subsidiary of DPV Parent, Inc., a Delaware corporation
(Parent), which is a wholly owned subsidiary of Double Point Ventures LLC, a Delaware limited liability company (DPV), pursuant to the terms and subject to the conditions of an Agreement and Plan of Merger, dated as of
October 22, 2024 (the Merger Agreement), by and among the Company, Purchaser and Parent, and, solely for the purpose of Section 9.17 of the Merger Agreement, DPV, to purchase all of the issued and outstanding shares of common
stock, par value $0.01 per share, of Lumos (Lumos Common Stock, and shares of Lumos Common Stock, Shares) (other than (x) Shares held in the treasury of Lumos or owned directly or indirectly by Parent or Purchaser
immediately prior to the Effective Time, which were canceled without any conversion thereof and no consideration delivered in exchange therefor, and (y) any Shares held by stockholders or owned by beneficial owners who were entitled to, and who
perfected, appraisal rights for such Shares in accordance with the DGCL), for (i) $4.25 per Share in cash, without interest and less applicable tax withholding (the Cash Amount), plus (ii) one
non-transferable, unsecured contingent value right per Share, which represents the right to receive additional contingent cash consideration (without interest thereon) payable upon achievement of certain
milestones as described in the Contingent Value Rights Agreement to be entered into between Parent and a rights agent (a CVR, and each CVR together with the Cash Amount, the Offer Price), all upon the terms and subject to the
conditions as set forth in the Offer to Purchase, dated November 13, 2024 (as may be amended or supplemented from time to time, the Offer to Purchase), and in the related Letter of Transmittal (as amended or supplemented from time
to time, the Letter of Transmittal, which, together with the Offer to Purchase, as each may be amended or supplemented from time to time, constitute the Offer).
The Offer is described in a Tender Offer Statement filed under cover of Schedule TO with the SEC on November 13, 2024, by DPV, Parent and
Purchaser (as amended or supplemented on November 29, 2024).
This Amendment is being filed to disclose certain updates as reflected
below. The information set forth in the Schedule 14D-9 remains unchanged and is incorporated herein by reference, except that such information is amended or supplemented to the extent specifically provided
herein. All paragraph headings and page references used herein refer to the headings and pages in the Schedule 14D-9 before any additions or deletions resulting from this Amendment or any other amendments.
Certain capitalized terms used below, unless otherwise defined, have the meanings set forth in the Schedule 14D-9. THIS AMENDMENT SHOULD BE READ IN CONJUNCTION WITH THE SCHEDULE 14D-9 AND THE SCHEDULE 14D-9 SHOULD BE READ IN ITS ENTIRETY.
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