Bruker Drives Ultrahigh-Resolution Qq-TOF Mass Spectrometry to New Performance Levels with Major Innovations in maxis™ Plat...
June 02 2011 - 6:00AM
Business Wire
Bruker, the pioneer of ultrahigh-resolution quadrupole
time-of-flight mass spectrometry, today announced a major extension
of the successful maXis™ UHR Qq-TOF technology range, which
Bruker will showcase at the ASMS 2011 conference in Denver,
Colorado, starting this Sunday, June 5.
maXis impact (Photo: Business Wire)
In March 2011, Bruker unveiled the revolutionary maXis 4G
system, setting entirely new performance heights with
record-breaking 60,000 full-sensitivity resolution (FSR) and 600
parts-per-billion (ppb) mass accuracy at UHPLC speed. The maXis
4G has the unique distinction of being the only simultaneous
high-speed, ultrahigh resolution and full sensitivity mass
spectrometer available today, with the dynamic range and
quantitative capabilities needed for many small molecule and
proteomics applications. The maXis 4G also excels in
top-down and intact protein analysis.
At ASMS 2011, Bruker will now complement the record performance
achievements of the maXis 4G by making uncompromised
UHR-QqTOF performance available in an affordable, convenient
format. The new maXis impact being introduced at ASMS is a
robust, benchtop instrument with outstanding performance to bring
the benefits of the unique maXis technology within reach of
all research, quality control, contract and industrial
laboratories.
The maXis impact has been designed for the new trend of
precise mass screening, a technique first pioneered by Bruker’s
collaborators, the University of Helsinki Department of Forensic
Medicine and now the leading emerging technique in forensic, drug
doping and food safety applications, and included for the first
time in the 2009 SANCO pesticide analysis guidelines. With an
unbeatable performance/price ratio, the new maXis impact is
designed to deliver unprecedented productivity to research, QC and
contract laboratories. Delivering 40,000 FSR and 1 ppm mass
accuracy, while acquiring at up to 50 full spectra per second, the
maXis impact is the instrument of choice for high-throughput
test laboratories, many of which are already equipped with UHPLC
separations to raise throughput. With remarkable MS/MS sensitivity
even at low mass fragments, the maXis impact rivals
traditional triple-quad instruments in trace analysis quantitation,
while offering all the flexibility and information content of
precise-mass assignment and ultra-high resolution at UHPLC speed
simultaneously.
“The new maXis impact high sensitivity MS/MS capability
boosts our bottom-up proteomics identification rates dramatically,”
commented Dr. Arnd Ingendoh, Bruker’s Director of Proteomics. “Our
customers can now dig deeper into the proteome with maXis
technology, as well as with complementary techniques, including our
class-leading MALDI-TOF/TOF systems, new glycomics tools, MALDI
imaging and ETD fragmentation for PTM analysis.”
Enhanced bottom-up identification in proteomics by combining
complementary technologies will be revealed in detail at Bruker’s
breakfast workshop at 7:00AM on Monday, June 6th in Room 702 of the
Denver Convention Center.
maXis Technology Explained: Several design
advances allow the maXis series to occupy a
technology class all of its own, delivering the only simultaneous
full sensitivity and high resolution (FSR) specification in the
industry. Breaking the 20-year convention where longer TOF flight
paths meant loss of sensitivity, the maXis series patented
in-flight ion optics refocus ions even during the TOF process
itself, and allow the full resolving potential of the long flight
path to be utilised, unobstructed by multiple reflectrons or ion
beam slicers which all degrade sensitivity significantly. Other
high-end Qq-TOF systems may nominally reach high resolution, but
only at the expense of a dramatic sensitivity loss suffered by
relying on resolution-compensating work-arounds like ion beam
slicing, multi-reflectrons, etc. Similarly, designs that use older
detection technology to gain speed require signal-discarding
devices to artificially ‘restore' dynamic range, which destroy the
ability to deal with coeluent analytes in complex mixtures.
About Bruker Corporation
Bruker Corporation (NASDAQ: BRKR) is a leading provider of
high-performance scientific instruments and solutions for molecular
and materials research, as well as for industrial and applied
analysis. For more information, please visit www.bruker.com.
For more information on maxis series, please visit
www.bruker.com/maxis
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