Bruker & the CDC Special Bacteriology Reference Laboratory Announce a Collaboration for Mass Spectrometry-based Microbial Ide...
June 18 2012 - 8:00AM
Business Wire
At the 112th General Meeting of the American Society of
Microbiology (ASM) in San Francisco, Bruker announces a new
collaboration with the Special Bacteriology Reference Laboratory
(SBRL) of the U.S. Centers for Disease Control and Prevention
(CDC).
The SBRL receives approximately 800 isolates of rare and unusual
bacteria from U.S. public health laboratories (PHLs) each year for
identification. SBRL maintains a culture collection of over 90,000
isolates that have been received over the past 60 years. Currently,
SBRL uses a polyphasic approach to identify unusual bacteria,
including both traditional microbiological and molecular testing.
Traditional biochemical tests may take weeks to complete. Molecular
methods, i.e. 16S rRNA gene sequencing, are more rapid, but the
public sequence databases may be incomplete and contain erroneous
sequences.
MALDI-TOF testing can be completed in hours and therefore has
the potential to produce more rapid results than traditional
microbiological testing methods. The goals of this announced
collaboration include: validation and expansion of the Bruker
MALDI Biotyper database of protein fingerprint profiles for
identification of unusual bacterial pathogens; evaluation of the
use of the Bruker MALDI Biotyper as a replacement for or in
conjunction with traditional biochemical testing in order to
decrease the time needed for accurate identification of
bacteria.
During the collaboration period of one year, each bacterial
isolate received by SBRL will be tested using the MALDI
Biotyper, traditional phenotypic and 16S ribosomal RNA gene
sequencing to validate the results. In addition, type strains of
known bacteria will be tested by the three methods. MALDI-TOF will
be evaluated for accuracy, reproducibility, and ease of use. Data
will be analyzed to determine the value of adding MALDI-TOF to the
SBRL testing algorithm.
This research collaboration will enhance the MALDI
Biotyper database as well as determine if the MALDI-TOF
platform can complement the other testing methods currently used by
SBRL and the US PHLs for bacterial identification.
Dr. Gongyi Shi, Director of Scientific Affairs in the
Microbiology business of Bruker Daltonics, commented: “We are very
excited to establish this collaboration with CDC’s Special
Bacteriology Reference Laboratory. The MALDI Biotyper has
been demonstrated to have superior performance, compared to
classical identification methods, for common bacteria representing
roughly 95% of the isolates in most clinical microbiology
laboratories. With SBRL’s worldwide acknowledged expertise in the
field and large collection of bacteria, especially those rare and
unusual bacteria, we will further improve the coverage of the
MALDI Biotyper reference library. Over time, this will allow
us to provide an even better solution to our customers.”
About the Bruker MALDI Biotyper
Bruker's dedicated MALDI Biotyper solution enables
molecular identification, taxonomical classification or
dereplication of microorganisms like bacteria, yeasts and fungi.
Classification and identification of microorganisms is achieved
reliably and fast using proteomic fingerprinting with
high-throughput MALDI-TOF mass spectrometry. Applications include
clinical routine microbial identification, environmental and
pharmaceutical analysis, taxonomical research, food and consumer
product processing and quality control, as well as in marine
microbiology. Bruker's robust MALDI Biotyper method requires
minimal sample preparation efforts and offers low cost per sample.
The MALDI Biotyper is available in a research-use-only
version, as well as in an IVD version according to the EU directive
EC/98/79 in various EU countries. For more information, please
visit www.bruker.com/MALDIBiotyper
About Bruker Corporation
Bruker Corporation (NASDAQ: BRKR) is a leading provider of high
performance scientific instruments and solutions for molecular and
materials research, as well as industrial and applied analysis. For
more information: www.bruker.com.
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