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UNITED STATES SECURITIES AND EXCHANGE COMMISSION |
WASHINGTON, D.C. 20549 |
| | |
| FORM 10-Q | |
(Mark one)
☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended June 30, 2023
or
☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from to
Commission File Number: 001-39452
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INHIBRX, INC. |
|
(Exact name of registrant as specified in its charter) |
| | |
Delaware | | 82-4257312 |
(State or other jurisdiction of incorporation or organization) | | (I.R.S. Employer Identification Number) |
| | |
11025 N. Torrey Pines Road, Suite 200 | | |
La Jolla, California | | 92037 |
(Address of principal executive offices) | | (Zip Code) |
| | |
| (858) 795-4220 | |
(Registrant’s telephone number, including area code) |
| | |
| N/A | |
(Former name, former address and former fiscal year, if changed since last report) |
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Securities registered pursuant to Section 12(b) of the Act |
| | | | | | |
Title of each class | | Trading Symbol(s) | | Name of each exchange on which registered |
Common Stock, par value $0.0001 | | INBX | | The Nasdaq Global Market |
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
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Large Accelerated Filer | ☐ | | Accelerated filer | ☐ |
Non-accelerated filer | ☒ | | Smaller reporting company | ☒ |
| | | Emerging growth company | ☐ |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Securities Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
As of July 31, 2023, the registrant had 43,668,153 shares of common stock outstanding.
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
This Quarterly Report on Form 10-Q, or this Quarterly Report, contains express and implied forward-looking statements that involve risks and uncertainties. Except as otherwise indicated by the context, references in this Quarterly Report to “we,” “us” and “our” are to the consolidated business of the Company. All statements other than statements of historical facts contained in this Quarterly Report are forward-looking statements. In some cases, you can identify forward-looking statements by words such as “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “possible,” “potential,” “predict,” “project,” “design,” “seek,” “should,” “target,” “will,” “would” or the negative of these words or other comparable terminology. These forward-looking statements include, but are not limited to, statements about:
•the initiation, timing, progress and results of our research and development programs as well as our preclinical studies and clinical trials;
•our ability to advance therapeutic candidates into, and successfully complete, clinical trials;
•our interpretation of initial, interim or preliminary data from our clinical trials, including interpretations regarding disease control and disease response;
•the timing or likelihood of regulatory filings and approvals;
•the commercialization of our therapeutic candidates, if approved;
•the pricing, coverage and reimbursement of our therapeutic candidates, if approved;
•our ability to utilize our technology platform to generate and advance additional therapeutic candidates;
•the implementation of our business model and strategic plans for our business and therapeutic candidates;
•our ability to successfully manufacture our therapeutic candidates for clinical trials and commercial use, if approved;
•our ability to contract with third-party suppliers and manufacturers and their ability to perform adequately;
•the scope of protection we are able to establish and maintain for intellectual property rights covering our therapeutic candidates;
•our ability to enter into strategic partnerships and the potential benefits of such partnerships;
•our estimates regarding expenses, capital requirements and needs for additional financing;
•our ability to raise funds needed to satisfy our capital requirements, which may depend on financial, economic and market conditions and other factors, over which we may have no or limited control;
•our and our third party partners’ and service providers’ ability to continue operations and advance our therapeutic candidates through clinical trials and the ability of our third party manufacturers to provide the required raw materials, antibodies and other biologics for our preclinical research and clinical trials in light of the current market conditions, labor conditions and geopolitical events;
•our ability to retain the continued service of our key professionals and to identify, hire and retain additional qualified professionals; and
•developments relating to our competitors and our industry.
These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including those described under the header “Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022, filed with the Securities and Exchange Commission, or the SEC, on March 6, 2023, and in our most recent Quarterly Report on Form 10-Q for the three months ended March 31, 2023, filed with the SEC on May 8, 2023. Moreover, we operate in a very competitive and rapidly changing environment, and new risks emerge from time to time. It is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements we may make. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed in this Quarterly Report may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. In addition, statements that “we believe” and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based upon information available to us as of the date of this Quarterly Report, and while we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete, and our statements should not be read to indicate that we have conducted an exhaustive
inquiry into, or review of, all potentially available relevant information. These statements are inherently uncertain and investors are cautioned not to unduly rely upon these statements.
You should not rely upon forward-looking statements as predictions of future events. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance or events and circumstances reflected in the forward-looking statements will be achieved or occur. We undertake no obligation to update publicly any forward-looking statements for any reason after the date of this Quarterly Report to conform these statements to new information, actual results or to changes in our expectations, except as required by law.
You should read this Quarterly Report and the documents that we file with the SEC with the understanding that our actual future results, levels of activity, performance and events and circumstances may be materially different from what we expect.
This Quarterly Report includes trademarks, tradenames and service marks that are the property of other organizations. Solely for convenience, trademarks and tradenames referred to in this Quarterly Report appear without the ® and ™ symbols, but those references are not intended to indicate, in any way, that we will not assert, to the fullest extent under applicable law, our rights, or that the applicable owner will not assert its rights, to these trademarks and tradenames.
TABLE OF CONTENTS
Part I — Financial Information
Item 1. Financial Statements.
Inhibrx, Inc.
Condensed Consolidated Balance Sheets
(In thousands, except share data and par value)
(Unaudited)
| | | | | | | | | | | |
| JUNE 30, | | DECEMBER 31, |
| 2023 | | 2022 |
| | | |
Assets | | | |
Current assets: | | | |
Cash and cash equivalents | $ | 192,492 | | | $ | 273,865 | |
Accounts receivable | 327 | | | 243 | |
Receivables from related parties | — | | | 14 | |
Prepaid expenses and other current assets | 10,502 | | | 6,371 | |
Total current assets | 203,321 | | | 280,493 | |
Property and equipment, net | 2,832 | | | 2,501 | |
Right-of-use asset | 3,853 | | | 4,717 | |
| | | |
Other non-current assets | 3,164 | | | 3,164 | |
Total assets | $ | 213,170 | | | $ | 290,875 | |
Liabilities and stockholders’ equity (deficit) | | | |
Current liabilities: | | | |
Accounts payable | $ | 9,700 | | | $ | 8,326 | |
Accrued expenses | 19,551 | | | 17,224 | |
Deferred revenue | 119 | | | 166 | |
| | | |
Current portion of lease liability | 1,959 | | | 1,860 | |
| | | |
| | | |
Total current liabilities | 31,329 | | | 27,576 | |
| | | |
| | | |
Long-term debt, including final payment fee | 204,482 | | | 202,069 | |
| | | |
Non-current portion of lease liability | 2,171 | | | 3,173 | |
| | | |
| | | |
| | | |
Total liabilities | 237,982 | | | 232,818 | |
Commitments and contingencies (Note 7) | | | |
| | | |
Stockholders’ equity (deficit) | | | |
Preferred stock, $0.0001 par value; 15,000,000 shares authorized as of June 30, 2023 and December 31, 2022; no shares issued or outstanding as of June 30, 2023 and December 31, 2022. | — | | | — | |
Common stock, $0.0001 par value; 120,000,000 shares authorized as of June 30, 2023 and December 31, 2022; 43,667,374 and 43,564,283 issued and outstanding as of June 30, 2023 and December 31, 2022, respectively. | 4 | | | 4 | |
Additional paid-in-capital | 443,525 | | | 430,426 | |
Accumulated deficit | (468,341) | | | (372,373) | |
Total stockholders’ equity (deficit) | (24,812) | | | 58,057 | |
Total liabilities and stockholders’ equity (deficit) | $ | 213,170 | | | $ | 290,875 | |
The accompanying notes are an integral part of these condensed consolidated financial statements.
Inhibrx, Inc.
Condensed Consolidated Statements of Operations
(In thousands, except per share data)
(Unaudited)
| | | | | | | | | | | | | | | | | | | | | | | |
| THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, |
| 2023 | | 2022 | | 2023 | | 2022 |
| | | |
Revenue: | | | | | | | |
License fee revenue | $ | 30 | | | $ | 711 | | | $ | 47 | | | $ | 1,626 | |
Grant revenue | — | | | — | | | — | | | 14 | |
Total revenue | 30 | | | 711 | | | 47 | | | 1,640 | |
Operating expenses: | | | | | | | |
Research and development | 34,106 | | | 29,906 | | | 71,492 | | | 54,801 | |
General and administrative | 7,263 | | | 5,402 | | | 13,660 | | | 10,453 | |
| | | | | | | |
Total operating expenses | 41,369 | | | 35,308 | | | 85,152 | | | 65,254 | |
Loss from operations | (41,339) | | | (34,597) | | | (85,105) | | | (63,614) | |
Other income (expense): | | | | | | | |
Interest expense | (7,905) | | | (3,202) | | | (15,468) | | | (5,520) | |
Interest income | 2,414 | | | 54 | | | 4,897 | | | 98 | |
Other income (expense), net | (217) | | | 17 | | | (287) | | | 54 | |
| | | | | | | |
| | | | | | | |
Total other expense | (5,708) | | | (3,131) | | | (10,858) | | | (5,368) | |
Loss before income tax expense | (47,047) | | | (37,728) | | | (95,963) | | | (68,982) | |
Provision for income taxes | 5 | | | 4 | | | 5 | | | 4 | |
| | | | | | | |
Net loss | (47,052) | | | (37,732) | | | (95,968) | | | (68,986) | |
Net loss per share, basic and diluted | $ | (1.08) | | | $ | (0.97) | | | $ | (2.20) | | | $ | (1.77) | |
Weighted-average shares of common stock outstanding, basic and diluted | 43,642 | | | 39,040 | | | 43,609 | | | 39,029 | |
The accompanying notes are an integral part of these condensed consolidated financial statements.
Inhibrx, Inc.
Condensed Consolidated Statements of Stockholders’ Equity (Deficit)
(In thousands)
(Unaudited)
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | Common Stock (Shares) | | Common Stock (Amount) | | Additional Paid-In Capital | | Accumulated Deficit | | Total Stockholders’ Equity (Deficit) |
Balance as of December 31, 2022 | | | | | | 43,564 | | | $ | 4 | | | $ | 430,426 | | | $ | (372,373) | | | $ | 58,057 | |
Stock-based compensation expense | | | | | | — | | | — | | | 5,636 | | | — | | | 5,636 | |
Issuance of shares upon exercise of stock options | | | | | | 31 | | | — | | | 356 | | | — | | | 356 | |
Net loss | | | | | | — | | | — | | | — | | | (48,916) | | | (48,916) | |
Balance as of March 31, 2023 | | | | | | 43,595 | | | $ | 4 | | | $ | 436,418 | | | $ | (421,289) | | | $ | 15,133 | |
Stock-based compensation expense | | | | | | — | | | — | | | 6,253 | | | — | | | 6,253 | |
Issuance of shares upon exercise of stock options | | | | | | 72 | | | — | | | 854 | | | — | | | 854 | |
Net loss | | | | | | — | | | — | | | — | | | (47,052) | | | (47,052) | |
Balance as of June 30, 2023 | | | | | | 43,667 | | | $ | 4 | | | $ | 443,525 | | | $ | (468,341) | | | $ | (24,812) | |
| | | | | | | | | | | | | | |
| | | | | | | | | | | | | | |
| | | | | | | | | | | | | | |
| | | | | | | | | | | | | | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| | | | | | Common Stock (Shares) | | Common Stock (Amount) | | Additional Paid-In Capital | | Accumulated Deficit | | Total Stockholders’ Equity (Deficit) |
Balance as of December 31, 2021 | | | | | | 38,991 | | | $ | 4 | | | $ | 279,526 | | | $ | (227,147) | | | $ | 52,383 | |
Stock-based compensation expense | | | | | | — | | | — | | | 5,108 | | | — | | | 5,108 | |
Issuance of shares upon exercise of stock options | | | | | | 35 | | | — | | | 401 | | | — | | | 401 | |
Issuance of warrants | | | | | | — | | | — | | | 712 | | | — | | | 712 | |
Net loss | | | | | | — | | | — | | | — | | | (31,254) | | | (31,254) | |
Balance as of March 31, 2022 | | | | | | 39,026 | | | $ | 4 | | | $ | 285,747 | | | $ | (258,401) | | | $ | 27,350 | |
Stock-based compensation expense | | | | | | — | | | — | | | 5,296 | | | — | | | 5,296 | |
Issuance of shares upon exercise of stock options | | | | | | 15 | | | — | | | 164 | | | — | | | 164 | |
Net loss | | | | | | — | | | — | | | — | | | (37,732) | | | (37,732) | |
Balance as of June 30, 2022 | | | | | | 39,041 | | | $ | 4 | | | $ | 291,207 | | | $ | (296,133) | | | $ | (4,922) | |
| | | | | | | | | | | | | | |
| | | | | | | | | | | | | | |
| | | | | | | | | | | | | | |
| | | | | | | | | | | | | | |
The accompanying notes are an integral part of these condensed consolidated financial statements.
Inhibrx, Inc.
Condensed Consolidated Statements of Cash Flows
(In thousands)
(Unaudited)
| | | | | | | | | | | |
| SIX MONTHS ENDED JUNE 30, |
| 2023 | | 2022 |
Cash flows from operating activities | | | |
Net loss | $ | (95,968) | | | $ | (68,986) | |
Adjustments to reconcile net loss to net cash used in operating activities: | | | |
Depreciation and amortization | 589 | | | 614 | |
Accretion of debt discount and non-cash interest expense | 2,413 | | | 1,171 | |
Stock-based compensation expense | 11,889 | | | 10,404 | |
Non-cash lease expense | 864 | | | 793 | |
Loss on disposal of fixed assets | 2 | | | 6 | |
Changes in operating assets and liabilities: | | | |
Accounts receivable | (84) | | | 130 | |
Receivables from related parties | 14 | | | 464 | |
Prepaid expenses and other current assets | (4,131) | | | 2,029 | |
| | | |
Other non-current assets | — | | | (1,317) | |
Accounts payable | 792 | | | 216 | |
Accrued expenses | 2,327 | | | 2,851 | |
Operating lease liability | (903) | | | (811) | |
Deferred revenue, current portion | (47) | | | (1,317) | |
Deferred revenue, non-current portion | — | | | (110) | |
| | | |
Net cash used in operating activities | (82,243) | | | (53,863) | |
Cash flows from investing activities | | | |
Purchase of fixed assets | (340) | | | (439) | |
| | | |
Net cash used in investing activities | (340) | | | (439) | |
Cash flows from financing activities | | | |
| | | |
| | | |
| | | |
| | | |
Proceeds from the issuance of debt | — | | | 98,871 | |
Payment of fees associated with debt | — | | | (50) | |
| | | |
| | | |
| | | |
Proceeds from the exercise of stock options | 1,210 | | | 565 | |
| | | |
Net cash provided by financing activities | 1,210 | | | 99,386 | |
Net increase (decrease) in cash and cash equivalents | (81,373) | | | 45,084 | |
Cash and cash equivalents at beginning of period | 273,865 | | | 131,301 | |
Cash and cash equivalents at end of period | $ | 192,492 | | | $ | 176,385 | |
Supplemental disclosure of cash flow information | | | |
Cash paid for interest | $ | 12,948 | | | $ | 3,975 | |
Cash paid for income taxes | $ | 5 | | | $ | 4 | |
Supplemental schedule of non-cash investing and financing activities | | | |
Payable for purchase of fixed assets | $ | 582 | | | $ | — | |
Fair value of warrants issued to lender in conjunction with February 2022 Amendment | $ | — | | | $ | 712 | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
The accompanying notes are an integral part of these condensed consolidated financial statements.
Inhibrx, Inc.
Notes to Unaudited Condensed Consolidated Financial Statements
1. ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Organization
Inhibrx, Inc., or the Company, or Inhibrx, is a clinical-stage biopharmaceutical company focused on developing a broad pipeline of novel biologic therapeutic candidates. The Company combines target biology with protein engineering, technologies, and research and development to design therapeutic candidates. The Company’s current pipeline is focused on oncology and orphan diseases.
Basis of Presentation
The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America, or GAAP, and applicable rules and regulations of the Securities and Exchange Commission, or the SEC, related to an interim report on the Form 10-Q. The unaudited condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiary. All intercompany accounts and transactions have been eliminated in consolidation.
The unaudited interim condensed consolidated financial statements reflect all adjustments which, in the opinion of management, are necessary for a fair statement of the results for the periods presented. All such adjustments are of a normal and recurring nature. The operating results presented in these unaudited interim condensed consolidated financial statements are not necessarily indicative of the results that may be expected for any future periods.
Certain information and note disclosures normally included in annual financial statements prepared in accordance with GAAP have been condensed or omitted. Accordingly, the accompanying unaudited interim condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the related notes thereto for the fiscal year ended December 31, 2022, which are included in the Company’s Annual Report on Form 10-K filed with the SEC on March 6, 2023.
Liquidity
As of June 30, 2023, the Company had an accumulated deficit of $468.3 million and cash and cash equivalents of $192.5 million. From its inception and through June 30, 2023, the Company has devoted substantially all of its efforts to therapeutic drug discovery and development, conducting preclinical studies and clinical trials, enabling manufacturing activities in support of its therapeutic candidates, pre-commercialization activities, organizing and staffing the Company, establishing its intellectual property portfolio and raising capital to support and expand these activities.
The Company believes that its existing cash and cash equivalents will be sufficient to fund the Company’s operations for at least 12 months from the date these condensed consolidated financial statements are issued. The Company plans to finance its future cash needs through equity offerings, debt financings or other capital sources, including potential collaborations, licenses, strategic transactions and other similar arrangements.
If the Company does raise additional capital through public or private equity or convertible debt offerings, the ownership interests of its existing stockholders will be diluted, and the terms of those securities may include liquidation or other preferences that adversely affect its stockholders’ rights. If the Company raises capital through additional debt financings, it may be subject to covenants limiting or restricting its ability to take specific actions, such as incurring additional debt or making certain capital expenditures. To the extent that the Company raises additional capital through strategic licensing, collaboration or other similar agreement, it may have to relinquish valuable rights to its therapeutic candidates, future revenue streams or research programs at an earlier stage of development or on less favorable terms than it would otherwise choose, or to grant licenses on terms that may not be favorable to the Company. There can be no assurance as to the availability or terms upon which such financing and capital might be available in the future. If the Company is unable to secure adequate additional funding, it will need to reevaluate its operating plan and may be forced to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible, delay, scale back or eliminate some or all of its development programs, or
relinquish rights to its technology on less favorable terms than it would otherwise choose. These actions could materially impact its business, financial condition, results of operations and prospects.
The rules and regulations of the SEC or any other regulatory agencies may restrict the Company’s ability to conduct certain types of financing activities, or may affect the timing of and amounts it can raise by undertaking such activities.
Use of Estimates
The preparation of these unaudited condensed consolidated financial statements in conformity with GAAP requires the Company to make estimates and judgments that affect the reported amounts of assets, liabilities, revenue and expense and the disclosure of contingent assets and liabilities in the Company’s financial statements and accompanying notes. The Company’s most significant estimates relate to evaluation of whether revenue recognition criteria have been met, accounting for development work and preclinical studies and clinical trials, determining the assumptions used in measuring stock-based compensation, the incremental borrowing rate estimated in relation to the Company’s operating lease, and valuation allowances for the Company’s deferred tax assets. The Company bases its estimates on historical experience, known trends and other market-specific or other relevant factors that it believes to be reasonable under the circumstances. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. The Company’s actual results may differ from these estimates under different assumptions or conditions.
Cash and Cash Equivalents
Cash and cash equivalents are comprised of cash held in financial institutions including readily available checking and money market accounts and highly liquid investments in debt securities with an original maturity of three months or less.
As of June 30, 2023, the Company’s investments in debt securities consisted of U.S. Treasury Bills, all of which mature in the third quarter of 2023. As of June 30, 2023, these investments were recorded at their amortized cost of $133.7 million, which was adjusted for the amortization or accretion of premiums or discounts.
Concentrations of Credit Risk
Financial instruments that subject the Company to significant concentrations of credit risk consist primarily of cash and cash equivalents, including investments in debt securities. The Company maintains deposits in federally insured financial institutions in excess of federally insured limits by the Federal Deposit Insurance Corporation, or FDIC, of up to $250,000. The Company’s investment portfolio consists of investments in U.S. Treasury securities, in excess of Securities Investor Protection Corporation limits of up to $500,000 in securities. The Company’s cash management and investment policy limits investment instruments to investment-grade securities with the objective to preserve capital and to maintain liquidity until the funds can be used in operations. The Company has not experienced any losses in such accounts and believes it is not exposed to significant risk on its cash balances due to the financial condition of the depository institutions in which those deposits are held.
Fair Value Measurements
The Company determines the fair value measurements of applicable assets and liabilities based on a three-tier fair value hierarchy established by accounting guidance and prioritizes the inputs used in measuring fair value. These tiers include:
•Level 1 - Quoted prices in active markets for identical assets or liabilities.
•Level 2 - Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.
•Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.
In certain cases, the inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, the level in the fair value hierarchy within which the fair value measurement in its entirety falls has been
determined based on the lowest level input that is significant to the fair value measurement in its entirety. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires judgment and considers factors specific to the asset or liability.
The Company’s investments in debt securities consist of U.S. Treasury Bills, which are classified as Level 1 in the fair value hierarchy. Due to the short-term nature of these securities which are classified as cash equivalents, the amortized value approximates fair value and the Company does not remeasure these instruments at fair value. The Company’s outstanding debt and warrants are both classified as Level 2 in the fair value hierarchy. As of June 30, 2023 and December 31, 2022, the Company had no financial instruments measured at fair value on a recurring basis.
Revenue Recognition
The Company has generated revenue from its license and collaboration agreements with partners, as well as from grants from government agencies and private not-for-profit organizations.
Collaborative Research, Development, and License Agreements
The Company enters into collaborative agreements with partners which may include the transfer of licenses, options to license and the performance of research and development activities. The terms associated with these agreements may include one or more of the following: (1) license fees; (2) nonrefundable up-front fees; (3) payments for reimbursement of research costs; (4) payments associated with achieving specific development, regulatory or commercial milestones; and (5) royalties based on specified percentages of net product sales, if any. Payments received from customers are included in deferred revenue, allocated between current and non-current on the condensed consolidated balance sheet, until all revenue recognition criteria are met.
Typically, license fees, non-refundable upfront fees and funding of research activities are considered fixed, while milestone payments, including option exercise fees, are identified as variable consideration, which is constrained and excluded from the transaction price. The Company will recognize revenue for sales-based royalty if and when a subsequent sale occurs.
The Company applies significant judgment when making estimates and assumptions under these agreements, including evaluating whether contractual obligations represent distinct performance obligations, including the assessment of whether options represent material rights, determining whether there are observable standalone prices and allocating transaction price to performance obligations within a contract, assessing whether any licenses are functional or symbolic, determining when performance obligations have been met, and assessing the recognition of variable consideration. The Company evaluates each performance obligation to determine if it can be satisfied and recognized as revenue at a point in time or over time. Typically, performance obligations consisting of a transfer of a license or the achievement of milestones are recognized at a point in time upon the transfer, while performance obligations consisting of research activities are recognized over time using an input method which is representative of the Company’s efforts to fulfill the performance obligation, based on costs incurred with third-parties or internal labor hours performed.
Accrued Research and Development and Clinical Trial Costs
Research and development costs are expensed as incurred and include the cost of compensation and related expenses, as well as expenses for third parties who conduct research and development on the Company’s behalf, pursuant to development and consulting agreements in place. The Company’s preclinical studies and clinical trials are performed internally, by third party contract research organizations, or CROs, and/or clinical investigators. The Company also engages with contract development and manufacturing organizations, or CDMOs, for clinical supplies and manufacturing scale-up activities related to its therapeutic candidates. Invoicing from these third parties may be monthly based upon services performed or based upon milestones achieved. The Company accrues these expenses based upon its assessment of the status of each clinical trial and the work completed, and upon information obtained from the CROs and CDMOs. The Company’s estimates are dependent upon the timeliness and accuracy of data provided by the CROs and CDMOs regarding the status and cost of the studies. Costs incurred related to the Company’s purchases of in-process research and development for early-stage products or products that are not commercially viable and ready for use, or have no alternative future use, are charged to expense in the period incurred. Costs incurred related to the licensing of products that have not yet received marketing approval to be
marketed, or that are not commercially viable and ready for use, or have no alternative future use, are charged to expense in the period incurred.
Income Taxes
Income taxes are accounted for under the asset and liability method. Deferred income taxes are recorded for temporary differences between financial statement carrying amounts and the tax basis of assets and liabilities. Deferred tax assets and liabilities reflect the tax rates expected to be in effect for the years in which the differences are expected to reverse. A valuation allowance is provided if it is more likely than not that some or all of the deferred tax assets will not be realized.
Net Loss Per Share
Basic net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding during the same period. Diluted net loss per share is computed by dividing net loss by the weighted average number of common and common equivalent shares outstanding during the same period. The Company excludes common stock equivalents from the calculation of diluted net loss per share when the effect is anti-dilutive.
For purposes of the diluted net loss per share calculation, warrants for purchase of common stock and stock options are considered to be potentially dilutive securities. Accordingly, for the six months ended June 30, 2023 and June 30, 2022, there is no difference in the number of shares used to calculate basic and diluted shares outstanding.
Potentially dilutive securities not included in the calculation of diluted net loss per share, because to do so would be anti-dilutive, are as follows (in thousands): | | | | | | | | | | | | | | | |
| AS OF JUNE 30, | | |
| 2023 | | 2022 | | | | |
| | | | | | | |
Outstanding stock options | 6,608 | | | 5,196 | | | | | |
| | | | | | | |
Warrants to purchase common stock | 47 | | | 47 | | | | | |
| 6,655 | | | 5,243 | | | | | |
Segment Information
The Company operates under one segment which develops biologic therapeutic candidates. Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker in making decisions regarding resource allocation and assessing performance.
Recent Accounting Pronouncements
From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board, or FASB, or other standard setting bodies. The Company believes that the impact of the recently issued accounting pronouncements that are not yet effective will not have a material impact on its condensed consolidated financial condition or results of operations upon adoption.
Adoption of New Accounting Pronouncements
In June 2016, the FASB issued Accounting Standards Update, or ASU, 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (Topic 326), which intends to improve financial reporting by requiring earlier recognition of credit losses on certain financial assets, such as held-to-maturity debt securities. Subsequent to the issuance of ASU 2016-13, the FASB issued several additional ASUs to clarify implementation guidance, provide narrow-scope improvements and provide additional disclosure guidance. The Company adopted ASU 2016-13 as of January 1, 2023, which did not result in a material impact on its condensed consolidated financial statements and related disclosures.
2. OTHER FINANCIAL INFORMATION
Prepaid Expense and Other Current Assets
Prepaid expense and other current assets were comprised of the following (in thousands):
| | | | | | | | | | | |
| AS OF | | AS OF |
| JUNE 30, 2023 | | DECEMBER 31, 2022 |
Clinical trials (1) | $ | 6,835 | | | $ | 4,294 | |
Clinical drug substance and product manufacturing (2) | 2,362 | | | 1,171 | |
Outside research and development services (3) | 280 | | | 232 | |
| | | |
Licenses | 701 | | | 493 | |
Other | 324 | | | 181 | |
Prepaid expense and other current assets | $ | 10,502 | | | $ | 6,371 | |
(1) Relates primarily to the Company’s prepayments to third-party CROs for management of clinical trials and prepayments for drug supply to be used in combination with the Company’s therapeutics. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development.
(2) Relates primarily to the Company’s usage of third-party CDMOs for clinical and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development.
(3) Relates to the Company’s usage of third-parties for other research and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development.
Property and Equipment, Net
Property and equipment, net were comprised of the following (in thousands):
| | | | | | | | | | | |
| AS OF | | AS OF |
| JUNE 30, 2023 | | DECEMBER 31, 2022 |
| | | |
Machinery and equipment | $ | 7,393 | | | $ | 7,023 | |
Leasehold improvements | 441 | | | 441 | |
Computer software | 53 | | | 53 | |
Furniture, fixtures, and other | 527 | | | 524 | |
Construction in process | 518 | | | — | |
Total property and equipment | 8,932 | | | 8,041 | |
Less: accumulated depreciation and amortization | (6,100) | | | (5,540) | |
Property and equipment, net | $ | 2,832 | | | $ | 2,501 | |
Depreciation and amortization expense totaled $0.3 million for each of the three months ended June 30, 2023 and June 30, 2022, and $0.6 million for each of the six months ended June 30, 2023 and June 30, 2022 and consisted of the following (in thousands):
| | | | | | | | | | | | | | | | | | | | | | | |
| THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, |
| 2023 | | 2022 | | 2023 | | 2022 |
Research and development | $ | 242 | | | $ | 248 | | | $ | 479 | | | $ | 506 | |
General and administrative | 53 | | | 59 | | | 110 | | | 108 | |
Total depreciation and amortization expense | $ | 295 | | | $ | 307 | | | $ | 589 | | | $ | 614 | |
Accrued Expenses
Accrued expenses were comprised of the following (in thousands):
| | | | | | | | | | | |
| AS OF | | AS OF |
| JUNE 30, 2023 | | DECEMBER 31, 2022 |
| | | |
Clinical trials(1) | $ | 8,185 | | | $ | 4,527 | |
Clinical drug substance and product manufacturing(2) | 3,335 | | | 5,381 | |
Other outside research and development (3) | 1,397 | | | 1,164 | |
Interest expense | 2,230 | | | 2,124 | |
Compensation-related | 3,390 | | | 3,374 | |
Professional fees | 674 | | | 428 | |
| | | |
Other | 340 | | | 226 | |
Accrued expenses | $ | 19,551 | | | $ | 17,224 | |
(1) Relates primarily to the Company’s usage of third-party CROs for management of clinical trials. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development.
(2) Relates primarily to the Company’s usage of third-party CDMOs for clinical and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development.
(3) Relates to the Company’s usage of third-parties for other research and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development.
3. DEBT
2020 Loan Agreement
In July 2020, the Company entered into a loan and security agreement, or the 2020 Loan Agreement, with Oxford Finance LLC, or Oxford, pursuant to which it received $10.0 million in gross proceeds, or Term A. The 2020 Loan Agreement was subsequently amended in November 2020, or the November 2020 Amendment, upon which a second tranche in an aggregate principal amount of $20.0 million was funded, or Term B, and in June 2021, or the June 2021 Amendment, upon which a third tranche in an aggregate principal amount of $40.0 million was funded, or Term C.
In February 2022, the Company entered into an additional amendment, or the February 2022 Amendment, to the 2020 Loan Agreement, collectively, the Amended 2020 Loan Agreement, upon which the Company received gross proceeds of $40.0 million, or Term D. The February 2022 Amendment also provided for an increase in the interest rate and for three future tranches of debt to be funded upon the achievement of certain milestones. In June 2022, the Company received additional gross proceeds of $30.0 million, or Term E, following the initiation of part 4 of the Phase 1/2 clinical trial of INBRX-105, as well as an additional $30.0 million in gross proceeds, or Term F, following the receipt of positive topline data from the Phase 1 clinical trial of INBRX-101.
In October 2022, the Company entered into an amendment to the Amended 2020 Loan Agreement, or the October 2022 Amendment. The October 2022 Amendment amended the milestone terms of the last remaining tranche, Term G, under the Amended 2020 Loan Agreement to provide for the funding of $30.0 million upon the announcement of the regulatory path for INBRX-101 rather than upon the initiation of a registration-enabling clinical trial of INBRX-101. In October 2022, the Company met this milestone and drew the final tranche for additional gross proceeds of $30.0 million.
The Company determined the November 2020, June 2021, February 2022, and October 2022 Amendments should be treated as modifications of the original 2020 Loan Agreement since the terms and resulting cash flows were not substantially changed upon each of the amendments. The Company will continue to amortize the existing debt discounts prior to modification through the Amended Maturity Date (as defined below).
As of June 30, 2023, the Company had $200.0 million in gross principal outstanding in term loans under the Amended 2020 Loan Agreement. The outstanding term loans will mature on January 1, 2027, or the Amended
Maturity Date, and bear interest at a floating per annum rate equal to the greater of (1) 8.30% or (2) the sum of (i) the 30 day U.S. Dollar LIBOR rate reported in The Wall Street Journal on the last business day of the month that immediately precedes the month in which the interest will accrue, plus (ii) 8.19%. Under the Amended 2020 Loan Agreement, the repayment schedule provides for interest-only payments through February 1, 2025, followed by 23 months of principal and interest payments, unless extended by a financing event as defined in the Amended 2020 Loan Agreement. In the event of a qualifying financing event in which the Company raises at least $100.0 million in upfront licensing or partnership proceeds by February 2025, the interest-only period may be extended an additional 12 months through February 1, 2026, which would then be followed by 11 months of equal payments of principal plus interest, beginning on March 1, 2026. Upon the Amended Maturity Date, a final payment of 9.0% of the original principal amount will be due to Oxford. This final payment of $18.0 million is being accreted over the life of the Amended 2020 Loan Agreement using the effective interest method. The Company has the option to prepay the outstanding balance of the term loans in full prior to the Amended Maturity Date, subject to a prepayment fee ranging from 1.0% to 3.0%, depending upon the timing of the prepayment.
The Company’s outstanding debt balance under the Amended 2020 Loan Agreement consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands).
| | | | | | | | | | | | | |
| AS OF | | AS OF | | |
| JUNE 30, 2023 | | DECEMBER 31, 2022 | | |
Term A | $ | 10,900 | | | $ | 10,900 | | | |
Term B | 21,800 | | | 21,800 | | | |
Term C | 43,600 | | | 43,600 | | | |
Term D | 43,600 | | | 43,600 | | | |
Term E | 32,700 | | | 32,700 | | | |
Term F | 32,700 | | | 32,700 | | | |
Term G | 32,700 | | | 32,700 | | | |
Less: debt discount | (13,518) | | | (15,931) | | | |
| | | | | |
| | | | | |
Long-term debt, including debt discount and final payment fee | $ | 204,482 | | | $ | 202,069 | | | |
As of June 30, 2023, and unless extended in accordance with the terms described above, the Company’s interest-only period will continue through February 2025, with principal payments beginning in March 2025. Future principal payments and final fee payments will be made as follows (in thousands):
| | | | | | | | | |
| | | AS OF | | |
| | | JUNE 30, 2023 | | |
2025 | | | $ | 86,956 | | | |
2026 | | | 104,348 | | | |
2027 | | | 26,696 | | | |
Total future minimum payments | | | 218,000 | | | |
Less: unamortized debt discount | | | (13,518) | | | |
Total debt | | | $ | 204,482 | | | |
The Company’s obligations under the Amended 2020 Loan Agreement are secured by a first priority security interest of substantially all of the Company’s assets with a positive lien on intellectual property. The Amended 2020 Loan Agreement includes customary events of default, including instances of a material adverse change in the Company’s operations, that may require prepayment of the outstanding term loans. Additionally, following the June 2021 Amendment, the Amended 2020 Loan Agreement requires the Company to maintain a minimum cash balance of $20.0 million. As of June 30, 2023, the Company is in compliance with all covenants under the Amended 2020 Loan Agreement and has not received any notification or indication from Oxford of an intent to declare the loan due prior to maturity.
Concurrently with the February 2022 Amendment, the Company issued 40,000 warrants to Oxford to purchase shares of the Company’s common stock at an exercise price of $45.00. Upon issuance, the warrants were classified as equity and recorded at their fair value of $0.7 million. See Note 4 for further discussion of these warrants.
Interest Expense
Interest expense is calculated using the effective interest method and is inclusive of non-cash amortization of the debt discount and accretion of the final payment. During the three months ended June 30, 2023, interest expense was $7.9 million, $1.2 million of which related to non-cash amortization of the debt discount and accretion of the final payment. During the three months ended June 30, 2022, interest expense was $3.2 million, $0.7 million of which related to non-cash amortization of the debt discount and accretion of the final payment. During the six months ended June 30, 2023, interest expense was $15.5 million, $2.4 million of which related to non-cash amortization of the debt discount and accretion of the final payment. During the six months ended June 30, 2022, interest expense was $5.5 million, $1.2 million of which related to non-cash amortization of the debt discount and accretion of the final payment.
4. STOCKHOLDERS’ EQUITY
Common Stock
In September 2021, the Company entered into the Open Market Sale Agreement, or the Sales Agreement, with Jefferies LLC, or the Sales Agent, under which it may, from time to time, sell shares of its common stock having an aggregate offering price of up to $200.0 million through the Sales Agent. Pursuant to the Sales Agreement, the Company will pay the Sales Agent a commission for its services in acting as an agent in the sale of common stock in an amount equal to 3% of the gross sales price per share sold. During each of the six months ended June 30, 2023 and June 30, 2022, the Company did not issue any shares under the Sales Agreement.
Common Stock Warrants
As of June 30, 2023, the following equity-classified warrants were outstanding:
| | | | | | | | | | | | | | |
Expiration Date | | Shares of Common Stock Issuable Upon Exercise of Warrants | | Exercise Price per Share |
July 15, 2030 | | 7,354 | | | $ | 17.00 | |
February 18, 2032 | | 40,000 | | $ | 45.00 | |
The Company’s warrants are equity-classified and carried at the instruments’ fair value upon classification into equity, with no subsequent remeasurements.
5. EQUITY COMPENSATION PLAN
Stock Incentive Plan
The Company’s share-based compensation plan, the Amended and Restated 2017 Employee, Director and Consultant Equity Incentive Plan, or the 2017 Plan, provides for the issuance of incentive stock options, restricted and unrestricted stock awards, and other stock-based awards. As of June 30, 2023, an aggregate of 7.8 million shares of common stock were reserved for issuance under the 2017 Plan, of which 0.5 million were available.
Stock Option Activity
The Company recognizes compensation costs related to stock-based awards, including stock options, based on the estimated fair value of the awards on the date of grant. The Company grants options with an exercise price equal to the fair market value of the Company’s stock on the date of the option grant. The options are subject to four-year vesting with a one-year cliff and have a contractual term of 10 years.
A summary of the Company’s stock option activity under its 2017 Plan for the six months ended June 30, 2023 is as follows (in thousands, except for per share data and years): | | | | | | | | | | | | | | | | | | | | | | | |
| Number of Shares | | Weighted Average Exercise Price | | Weighted Average Remaining Contractual Term (In Years) | | Aggregate Intrinsic Value |
| | | | | | | |
| | | | | | | |
| | | | | | | |
Outstanding as of December 31, 2022 | 5,305 | | | $ | 22.95 | | | | | |
Granted | 1,478 | | | $ | 23.10 | | | | | |
Exercised | (103) | | | $ | 11.74 | | | | | |
Forfeited | (72) | | | $ | 28.35 | | | | | |
Outstanding as of June 30, 2023 | 6,608 | | | $ | 23.10 | | | 8.1 | | $ | 35,768 | |
Vested and exercisable as of June 30, 2023 | 2,855 | | | $ | 20.93 | | | 6.9 | | $ | 22,466 | |
The aggregate intrinsic value of stock options exercised during the six months ended June 30, 2023 and June 30, 2022 was $1.3 million and $1.0 million, respectively. Aggregate intrinsic value of stock options exercised and outstanding is calculated using the fair value of common stock on the date of exercise and as of June 30, 2023, respectively. The total fair value of stock options vested during the six months ended June 30, 2023 and June 30, 2022 was $13.8 million and $16.1 million, respectively. The Company expects all outstanding stock options to vest.
Stock-Based Compensation Expense
The weighted-average assumptions used by the Company to estimate the fair value of stock option grants using the Black-Scholes option pricing model, as well as the resulting weighted-average fair value for the six months ended June 30, 2023 and June 30, 2022 were as follows:
| | | | | | | | | | | |
| SIX MONTHS ENDED JUNE 30, |
| 2023 | | 2022 |
| | | |
Risk-free interest rate | 3.73 | % | | 2.17 | % |
Expected volatility | 84.35 | % | | 85.12 | % |
Expected dividend yield | — | % | | — | % |
Expected term (in years) | 6.08 | | 6.08 |
Weighted average fair value | $ | 16.97 | | | $ | 18.75 | |
Stock-based compensation expense for stock options consisted of the following (in thousands):
| | | | | | | | | | | | | | | | | | | | | | | |
| THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, |
| 2023 | | 2022 | | 2023 | | 2022 |
Research and development | $ | 4,245 | | | $ | 3,540 | | | $ | 8,094 | | | $ | 7,219 | |
General and administrative | 2,008 | | | 1,756 | | | 3,795 | | | 3,185 | |
Total stock-based compensation expense | $ | 6,253 | | | $ | 5,296 | | | $ | 11,889 | | | $ | 10,404 | |
As of June 30, 2023, the Company had $64.4 million of total unrecognized stock-based compensation expense related to its stock options, which is expected to be recognized over a weighted-average period of 2.8 years.
6. LICENSE AND GRANT REVENUES
The following table summarizes the total revenue recorded in the Company’s condensed consolidated statements of operations (in thousands): | | | | | | | | | | | | | | | | | | | | | | | |
| THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, |
| 2023 | | 2022 | | 2023 | | 2022 |
| | | | | | | |
| | | | | | | |
| | | | | | | |
| | | | | | | |
License fee revenue | | | | | | | |
Chiesi Farmaceutici S.p.A. | $ | 30 | | | $ | 98 | | | $ | 47 | | | $ | 339 | |
Phylaxis BioScience, LLC | — | | | 413 | | | — | | | 1,087 | |
2seventy bio, Inc. | — | | | 200 | | | — | | | 200 | |
| | | | | | | |
Total license fee revenue | 30 | | | 711 | | | 47 | | | 1,626 | |
| | | | | | | |
| | | | | | | |
| | | | | | | |
| | | | | | | |
Grant revenue | — | | | — | | | — | | | 14 | |
Total revenue | $ | 30 | | | $ | 711 | | | $ | 47 | | | $ | 1,640 | |
License and Collaboration Agreements
Chiesi
In May 2019, the Company entered into an Option Agreement, as amended by the First Amendment to Option Agreement, dated August 19, 2019, or the Chiesi Option Agreement, with Chiesi Farmaceutici S.p.A., or Chiesi, pursuant to which the Company granted to Chiesi an exclusive option to obtain an exclusive license to develop and commercialize INBRX-101 outside of the United States and Canada. Additionally, the Chiesi Option Agreement provides Chiesi with a right of negotiation for INBRX-101 development and commercialization rights in the United States and Canada in the event that the Company engages in discussions with any third parties for such rights during the term of the Chiesi Option Agreement or, as applicable, the term of a definitive exclusive license agreement between Chiesi and the Company. Under the terms of the Chiesi Option Agreement, the Company received a one-time, non-refundable option initiation payment of $10.0 million in August 2019. If Chiesi chooses to exercise its option under the Chiesi Option Agreement, then Chiesi must pay the Company a one-time, non-refundable fee of $12.5 million upon the effective date of the definitive agreement granting Chiesi the exclusive license. If the option is exercised, under the license agreement, the Company may be entitled to receive specified milestone payments of up to $122.5 million, as well as royalties on future product sales.
The Company has identified one performance obligation as of the effective date of the Chiesi Option Agreement, which is to perform research and development services for Chiesi during the option period, which will continue (unless the Chiesi Option Agreement is terminated earlier by Chiesi or the Company) until 60 days following the last to occur of (i) the Company’s delivery to Chiesi of the trial phase data for the first Phase I Clinical Trial, (ii) the Company’s delivery to Chiesi of the finalized minutes from the definitive U.S. Food and Drug Administration, or FDA, scientific advice meeting conducted following completion of such Phase I Clinical Trial, and (iii) the Company’s delivery to Chiesi of written scientific advice from the European Medicines Agency following completion of such Phase I Clinical Trial. The Company has determined that the option to grant a license in the future is not a material right. On July 24, 2023, the Company received written scientific advice from the EMA which confirmed CT lung densitometry as the established primary regulatory endpoint to support a marketing authorization application in the European Union for the treatment of emphysema secondary to AATD. The Company provided a copy of the EMA scientific advice to Chiesi upon receipt which, as described above, fulfilled the necessary deliverables to Chiesi and triggered its 60-day option period window. If Chiesi chooses to exercise its option by September 22, 2023, pursuant to the Chiesi Option Agreement, a one-time, non-refundable option exercise payment of $12.5 million will be payable to the Company.
The $10.0 million upfront payment has been allocated to the single performance obligation. Revenue is recognized over time as services are performed during the option period, based on the Company’s effort to satisfy the performance obligation relative to the total expense estimated to be incurred during the option period. During the three months ended June 30, 2023 and June 30, 2022, the Company recognized $17,000 and $0.1 million in revenue related to this agreement, respectively. During the six months ended June 30, 2023 and June 30, 2022, the Company recognized $47,000 and $0.3 million in revenue related to this agreement, respectively. As of June 30, 2023 and
December 31, 2022, the Company had $0.1 million of deferred revenue related to this agreement at each date, all of which is classified as current deferred revenue in each period.
Phylaxis
In July 2020, the Company entered into a joint venture with Phylaxis BioScience, LLC, or Phylaxis. In connection with the joint venture, the Company entered into the following agreements: Contribution Agreement, License Agreement, Limited Liability Company Agreement and Master Services Agreement, or collectively the Phylaxis Agreements, pursuant to which the Company licensed certain intellectual property and know-how to Phylaxis and agreed to provide services to develop certain compounds. Upon closing, the Company received a $2.5 million nonrefundable, upfront payment from Phylaxis under the Master Services Agreement, or the MSA. The Company has also received an additional $2.5 million, which was payable within 180 days from closing under the MSA, in two payments of $1.25 million each, received in October 2020 and January 2021. Upon closing, the Company received a 10% equity interest in Phylaxis as consideration for the contribution of the license of the Company’s intellectual property and know-how and is entitled to receive an additional 5% based on the achievement of certain milestones. Under the License Agreement, the Company is also entitled to specified development and commercialization milestone payments of up to an aggregate of $225.0 million and $175.0 million, respectively. The Company is also entitled to share in a percentage of the profits of Phylaxis under the Limited Liability Company Agreement.
In order to determine the fair value of the equity interest in Phylaxis, the Company engaged a third-party valuation specialist. The valuation report utilized a market approach to establish the total equity value of Phylaxis using inputs not observable in the market, including the discount rate. The fair value of the equity interest was $0.5 million, which has been accounted for under the equity method. The fair value of the equity interest upon the execution of the agreements has been included in the transaction price, along with the $5.0 million of payments due pursuant to the MSA.
The Company identified the transfer of the exclusive licenses for, and performance of, development services to modify the first and second compounds as one performance obligation and allocated the transaction price evenly between the two compounds. Revenue related to the performance obligation will be recognized over time as services are performed, based on the Company’s progress to satisfy the performance obligation. During the third quarter of 2022, the Company fulfilled this performance obligation in full and recognized all remaining deferred revenue under this contract.
During the three and six months ended June 30, 2023, the Company recognized no revenue related to this performance obligation following its completion in 2022. During the three months ended June 30, 2022, the Company recognized $0.4 million of revenue related to this performance obligation. During the six months ended June 30, 2022, the Company recognized $1.1 million of revenue related to this performance obligation. As of June 30, 2023 and December 31, 2022, there was no deferred revenue remaining related to the Phylaxis Agreements.
2seventy
In June 2020, the Company entered into an Option and License Agreement with bluebird bio, Inc., or bluebird, pursuant to which the Company granted to bluebird exclusive worldwide rights to develop binders and cell therapy products containing single domain antibodies, or sdAbs, directed to specified targets, consisting of two initial programs and up to an additional 8 programs. The Company retains all rights to the specific sdAbs outside of the cell therapy field. In November 2021, this agreement, or the 2020 2seventy Agreement, was also assigned to 2seventy bio, Inc., or 2seventy, in connection with bluebird’s internal restructuring and subsequent spin-out of 2seventy.
In June 2020, the Company received a non-refundable upfront option fee of $0.2 million in connection with each of the two initial programs, or $0.4 million in aggregate, and is entitled to an upfront option fee for each additional program, on a program-by-program basis. In June 2022, 2seventy selected a third program and paid a non-refundable upfront option fee of $0.2 million in exchange for a development license. Under each of the three programs, the Company granted an option in which 2seventy may acquire an exclusive license with respect to all binders and cell therapy products developed under this agreement, which entitles the Company to additional fees upon exercise of the option. In connection with each program for which 2seventy exercises its option, 2seventy will
be required to pay the Company a one-time, non-refundable, non-creditable fee in the low-single-digit millions. The Company is also entitled to receive certain developmental milestone payments of up to an aggregate of $51.5 million per therapeutic, as well as percentage tiered royalties on future product sales with rates in the mid-single-digits. Due to the uncertainty in the achievement of the developmental milestones and future sales, the variable consideration associated with the future milestone payments has been fully constrained (excluded) from the transaction price until such time that the Company concludes that it is probable that a significant reversal of previously recognized revenue will not occur. These estimates will be re-assessed at each reporting period.
As of the effective date of the 2020 2seventy Agreement, the Company identified one performance obligation, which was the transfer of the exclusive development license to bluebird for the two initial programs. The Company determined that the option granted for an exclusive license in the future was not a material right. For the eight programs not identified upon execution of the contract, the Company evaluated the customer option for additional purchases and determined that those options for additional programs did not constitute material rights nor variable consideration. As additional programs are identified, the Company re-assesses its performance obligations and transaction price accordingly.
In June 2022, pursuant to the terms regarding the addition of new programs in the 2020 2seventy Agreement, the Company received a $0.2 million upfront option fee related to the selection of a third program and transferred the related know-how and development license. The Company recognized the $0.2 million of revenue at the point in time in which the program was added and the program term began.
During the three and six months ended June 30, 2022, the Company recognized $0.2 million of revenue related to this agreement. During the three and six months ended June 30, 2023, the Company did not recognize any revenue related to this agreement.
7. COMMITMENTS AND CONTINGENCIES
Operating Leases
In September 2017, the Company entered into a seven-year lease agreement as its sole location in La Jolla, California. The lease expires in June 2025 with an option to extend the lease an additional five years. The lease contained an initial base rent of approximately $0.1 million per month with 2% annual escalations, plus a percentage of taxes and operating expenses incurred by the lessor in connection with the ownership and management of the property, the latter of which to be determined annually.
In May 2019, the Company executed an amendment to its lease agreement to expand its facilities and began occupying this space in January 2020. The amended lease terminates coterminously with the initial lease agreement and contains an initial base rent of approximately $30,000 per month with 2% annual escalations, plus a percentage of taxes and operating expenses incurred by the lessor in connection with the ownership and management of the property, the latter of which is to be determined annually.
The right-of-use asset and operating lease liability as of June 30, 2023 and December 31, 2022 are as follows (in thousands):
| | | | | | | | | | | |
| AS OF | | AS OF |
| JUNE 30, 2023 | | DECEMBER 31, 2022 |
| | | |
Right-of-use asset | $ | 3,853 | | | $ | 4,717 | |
| | | |
Operating lease liability | | | |
Current | $ | 1,959 | | | $ | 1,860 | |
Non-current | 2,171 | | | $ | 3,173 | |
Total operating lease liability | $ | 4,130 | | | $ | 5,033 | |
During each of the three months ended June 30, 2023 and June 30, 2022, the Company recognized operating lease expense of $0.8 million. During the six months ended June 30, 2023 and June 30, 2022, the Company recognized
operating lease expense of $1.7 million and $1.6 million, respectively. During each of the three months ended June 30, 2023 and June 30, 2022, the Company paid $0.5 million in cash for amounts included in the measurement of the operating lease liability. During each of the six months ended June 30, 2023 and June 30, 2022, the Company paid $1.1 million in cash for amounts included in the measurement of the operating lease liability.
As of June 30, 2023 and December 31, 2022, the Company’s operating lease had a remaining term of 2.0 and 2.5 years, respectively. The Company discounts its lease payments using its incremental borrowing rate as of the commencement of the lease. The Company has determined a weighted-average discount rate of 8.2% as of June 30, 2023 and December 31, 2022.
Future minimum rental commitments for the Company’s operating leases reconciled to the lease liability are as follows (in thousands):
| | | | | | | |
| AS OF | | |
| JUNE 30, 2023 | | |
| | | |
2023 | $ | 1,110 | | | |
2024 | 2,247 | | | |
2025 | 1,137 | | | |
Thereafter | — | | | |
Total future minimum lease payments | $ | 4,494 | | | |
Less: imputed interest | (364) | | | |
Present value of operating lease liability | 4,130 | | | |
Less: current portion of operating lease liability | (1,959) | | | |
Non-current portion of operating lease liability | $ | 2,171 | | | |
Purchase Commitments
The Company has several ongoing contracts with CROs for preclinical studies and clinical trials and with CDMOs for clinical supplies and manufacturing scale-up activities. While these contracts are generally cancellable, some may contain specific activities that involve one or more non-cancellable commitments, including minimum purchase commitments, binding annual forecasts and capital equipment investments. Additionally, depending on the timing and reasoning of the exit, certain termination penalties may apply and can range from cost of work performed to date and up to twelve months of future committed manufacturing costs. As of June 30, 2023 and December 31, 2022, the non-cancellable portion of these contracts total in aggregate, excluding amounts paid or incurred at each respective date, approximately $76.5 million and $74.8 million, respectively. The non-cancellable purchase commitments relate to the purchase of raw materials and future contract manufacturing of drug supply for INBRX-101. During the six months ended June 30, 2023 and June 30, 2022, the Company incurred $1.0 million and $0.6 million, respectively, of expenses related to its non-cancellable purchase agreements.
Litigation
The Company is not party to any material legal proceedings. From time to time, it may be involved in legal proceedings or subject to claims incident to the ordinary course of business. Regardless of the outcome, such proceedings or claims can have an adverse impact on the Company because of defense and settlement costs, diversion of resources and other factors, and there can be no assurances that favorable outcomes will be obtained.
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.
You should read the following discussion and analysis of our financial condition and results of operations together in conjunction with our condensed consolidated financial statements and related notes included in Part I, Item 1 of this Quarterly Report, and our audited consolidated financial statements and notes thereto as of and for the fiscal year ended December 31, 2022 and the related Management’s Discussion and Analysis of Financial Condition and Results of Operations, both of which are contained in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022, filed with the SEC on March 6, 2023. Some of the information contained in this discussion and analysis or set forth elsewhere in this Quarterly Report contain forward-looking statements that involve risk and uncertainties, including those described in the section titled “Special Note Regarding Forward-Looking Statements.” As a result of many factors, our actual results could differ materially from the results described in or implied by the forward-looking statements contained in the following discussion and analysis.
Overview
We are a clinical-stage biopharmaceutical company with a pipeline of novel biologic therapeutic candidates developed using our proprietary modular protein engineering platforms. In particular, our proprietary single domain antibody, or sdAb, platform allows us to pursue validated targets with clinical promise where other antibody and biologic based approaches have failed. Highly modular, our platform technologies can be combined with precise valencies and multiple specificities, creating therapeutic candidates designed to be capable of enhanced cell signaling, conditional activation or combined synergistic functions.
We have multiple programs in various stages of development from discovery to preclinical to clinical. We currently have four programs in ongoing clinical trials. Three of these programs are for the treatment of various cancers, and one for the treatment of Alpha-1 Antitrypsin Deficiency, or AATD, as shown below:
| | | | | | | | | | | | | | | | | | | | |
|
INBRX-101 | | INBRX-109 | | INBRX-105 | | INBRX-106 |
AAT-Fc fusion protein | | Tetravalent DR5 agonist | | PD-L1x4-1BB tetravalent conditional agonist | | Hexavalent OX40 agonist |
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Program | Therapeutic Area | Target(s)/Format | STAGE OF DEVELOPMENT |
Preclinical | Phase 1 | Phase 2 | Phase 3 |
INBRX-101* | Orphan/Respiratory | Neutrophil Elastase AAT-Fusion Protein | |
| |
|
INBRX-109** | Oncology | DR5 Tetravalent Agonist | |
| |
|
INBRX-105*** | Oncology | PD-L1 x 4-1BB Tetravalent Conditional Agonist | |
| |
|
INBRX-106*** | Oncology | OX40 Hexavalent Agonist | |
| |
|
| | | |
| |
|
__________________
* Commercialization and development rights outside of the United States and Canada, subject to an option agreement, or the Chiesi Option Agreement, with Chiesi Farmaceutici S.p.A., or Chiesi.
** Third party partnership with Chinese biotechnology company, Transcenta Holding, Ltd., or Transcenta, currently in place for development and commercialization in China, Hong Kong, Macau and/or Taiwan.
*** Third party partnership with Chinese biotechnology company, Elpiscience Biopharmaceuticals, Inc, or Elpiscience, currently in place for development and commercialization in China, Hong Kong, Macau and/or Taiwan.
INBRX-101 is an optimized, recombinant alpha-1 antitrypsin, or AAT, augmentation therapy candidate for AATD. In March 2022, the FDA granted orphan drug designation for INBRX-101 for the treatment of AATD. In May 2022, we announced topline results from the INBRX-101 Phase 1 clinical trial. We believe the data revealed the potential to achieve normal AAT levels with less frequent dosing than the current standard of care and showed the treatment was well tolerated with no drug-related severe or serious adverse events at doses up to and including 120 mg/kg in single and multi-dose administered intravenously. In April 2023, we initiated ElevAATe, a registration-enabling trial for INBRX-101 for the treatment of patients with emphysema due to AATD. The primary endpoint of the trial is the mean change in the average functional AAT, or fAAT, concentration as measured by anti-neutrophil elastase capacity from baseline to average serum trough fAAT concentration at steady state (Ctrough,ss). The initial read-out from the ElevAATe trial is expected to occur in late 2024 and we intend to submit for regulatory approval once completed. In our end of Phase 1 meeting, the FDA requested additional information to support the correlation between serum AAT levels and the clinical benefit in AATD to further support serum AAT levels as a surrogate endpoint reasonably likely to predict clinical benefit. We are in the process of compiling this data through existing registry, health records and published data and plan to submit those analyses to the FDA as part of the BLA submission. In May 2023, the FDA granted Fast Track designation to INBRX-101 for the treatment of patients with emphysema due to AATD.
Our most advanced therapeutic candidate, INBRX-109, is a tetravalent death receptor 5, or DR5, agonist currently being evaluated in patients diagnosed with difficult-to-treat cancers, such as chondrosarcoma, mesothelioma, colorectal cancer, Ewing sarcoma and pancreatic adenocarcinoma. In June 2021, based on the initial Phase 1 data results, we initiated a registration-enabling Phase 2 trial for the treatment of unresectable or metastatic conventional chondrosarcoma for which the FDA and the European Medicine Agency, or EMA, granted orphan drug designation in November 2021 and August 2022, respectively. In November 2022, we announced updated efficacy and safety data from the ongoing Phase 1 INBRX-109 expansion cohorts for the treatment of chondrosarcoma, which showed disease control was observed in patients with and without isocitrate dehydrogenase, or IDH, mutations. Phase 1 combination cohorts are expected to begin reading out by the end of 2023 and data from the registration-enabling trial in unresectable or metastatic conventional chondrosarcoma is expected during the second half of 2024.
INBRX-105 is a precisely engineered multi-specific sdAb-based therapeutic candidate that is designed to agonize 4-1BB selectively in the presence of PD-L1, which is typically found in the tumor microenvironment and associated lymphoid tissues. It is currently being investigated as a single agent and in combination with Keytruda, a PD-1 blocking checkpoint inhibitor, in patients with locally advanced or metastatic solid tumors. Parts 1 and 3, dose
escalation as a single agent and in combination with Keytruda, have been completed. We continue to enroll and/or have active patients in Part 2, single agent dose expansion, and Part 4, combination expansion cohorts. We expect to announce initial data from these cohorts mid-year of 2024.
INBRX-106 is a precisely engineered hexavalent sdAb-based therapeutic candidate targeting OX40, designed to be an optimized agonist of this co-stimulatory receptor. It is currently being investigated as a single agent and in combination with Keytruda in patients with locally advanced or metastatic solid tumors. Parts 1 and 3, dose escalation as a single agent and in combination with Keytruda, have been completed. It was observed to be well tolerated, with predominantly mild or moderate immune-related toxicities notes. We observed durable responses across multiple tumor types. We continue to enroll and/or have active patients in Part 2, single agent dose expansion, and Part 4, combination expansion cohorts. We expect to announce initial data from these cohorts during the second half of 2024.
License and Collaboration Agreements
Celgene Agreement
On July 1, 2013, we entered into a license agreement with Celgene Corporation, a Bristol Myers Squibb Company, or Celgene, as amended on November 23, 2018, or the Celgene Agreement, pursuant to which we granted Celgene an exclusive, global license for the development, manufacture and commercialization of our proprietary CD47 binding domain, or the Celgene Licensed Intellectual Property. Per the terms of the Celgene Agreement, Celgene is operationally and financially responsible for the development, manufacturing and commercialization activities of Celgene Licensed Intellectual Property and any additional related antibodies covered by the Celgene Agreement.
As payment for the license granted in the Celgene Agreement, we may be eligible to receive development and regulatory milestones of an aggregate of $934.1 million, assuming the achievement of all potential milestones in the Celgene Agreement, as well as percentage tiered royalties based on future worldwide sales, with rates ranging from the high single-digits to the low teens, subject to potential reduction when and if comparable third party products attain certain levels of competitive market share (on a country-by-country basis) and, subject to certain limitations, payments to third parties for third-party intellectual property rights. We are obligated to pay 2% of future amounts received under the Celgene Agreement to advisors who assisted us with the negotiations and other matters in connection with the Celgene Agreement.
2seventy Agreements
On December 20, 2018, we entered into an exclusive license agreement with bluebird bio, Inc., or bluebird, to research, develop and commercialize CAR T-cell therapies using our proprietary sdAb platform. In November 2021, bluebird assigned this license agreement, or the 2018 2seventy Agreement, to its affiliate 2seventy bio, Inc., or 2seventy, in connection with an internal restructuring and subsequent spin-out of 2seventy. Under the terms of this license agreement, we provided 2seventy the exclusive worldwide rights to develop, manufacture and commercialize certain cell therapy products containing sdAbs directed to various cancer targets. To date, we have received $9.0 million in payments pursuant to the license agreement. We are entitled to receive developmental milestone payments of up to an aggregate of $51.5 million per therapeutic, as well as percentage tiered royalties on future product sales with rates in the mid-single digits.
On June 9, 2020, we entered into an option and license agreement with bluebird, or the 2020 2seventy Agreement, which was also assigned to 2seventy in November 2021 in connection with bluebird’s internal restructuring and subsequent spin-out of 2seventy. In June 2020, we received a non-refundable upfront option fee of $0.2 million in connection with each of the two initial programs, or $0.4 million in aggregate, and we are entitled to an upfront option fee for each additional program. In June 2022, 2seventy selected a third program and paid an additional $0.2 million as a non-refundable upfront option fee in exchange for a development license. We also granted options in which 2seventy may acquire an exclusive license with respect to all binders and cell therapy products developed under the 2020 2seventy Agreement, which entitles us to additional fees upon exercise of an option for each program. Additionally, 2seventy may extend the option term for up to six months in the event that there are additional bona fide development activities that 2seventy desires to undertake. We are also entitled to receive certain developmental milestone payments of up to an aggregate of $51.5 million per therapeutic, as well as percentage tiered royalties on future product sales with rates in the mid-single-digits.
In May 2021, pursuant to the option extension terms in the 2020 2seventy Agreement, bluebird requested to extend the option term for one of the initial programs by an additional six months in exchange for an option extension fee of $0.1 million. In August 2021, pursuant to the option exercise terms in the agreement, bluebird exercised its option to exclusively license one of the initial programs in exchange for an option exercise fee of $2.1 million, the payment of which was received in October 2021. In May 2023, 2seventy declined to exercise its option to license the second of the initial programs.
Chiesi
In May 2019, we entered into the Chiesi Option Agreement with Chiesi. Under this agreement, we granted to Chiesi an exclusive option to obtain an exclusive license to develop and commercialize INBRX-101 outside of the United States and Canada. Additionally, the Chiesi Option Agreement provides Chiesi with a right of negotiation for INBRX-101 development and commercialization rights in the United States and Canada in the event we engage in discussions with any third parties for such rights during the term of the Chiesi Option Agreement or, as applicable, the term of a definitive exclusive license agreement between Chiesi and the Company. Under the terms of the Chiesi Option Agreement, we received a one-time, non-refundable option initiation payment of $10.0 million in August 2019. Pursuant to the Chiesi Option Agreement, we are performing research and development services for Chiesi during the option period, which will continue (unless the Chiesi Option Agreement is terminated earlier by the Chiesi or the Company) until 60 days following the last-to-occur of (i) the Company’s delivery to Chiesi of the trial phase data for the first Phase I Clinical Trial for INBRX-101 (including the complete clinical study report), (ii) the Company’s delivery to Chiesi of the finalized minutes from the definitive FDA scientific advice meeting conducted following completion of such Phase I Clinical Trial with the use of the full clinical study report if required by the FDA, and (iii) the Company’s delivery to Chiesi of written scientific advice from the EMA following completion of such Phase I Clinical Trial with full use of the clinical study report if required by the EMA. On July 24, 2023, we received written scientific advice from the EMA which confirmed CT lung densitometry as the established primary regulatory endpoint to support a marketing authorization application in the European Union for the treatment of emphysema secondary to AATD. We provided a copy of the EMA scientific advice to Chiesi upon receipt which, as described above, fulfilled the necessary deliverables to Chiesi and triggered its 60-day option period window.
If Chiesi chooses to exercise its option under the Chiesi Option Agreement, we will receive a one-time, non-refundable fee of $12.5 million upon the effective date of the definitive agreement granting Chiesi the exclusive license. If the option is exercised, under the license agreement, we may be entitled to receive specified milestone payments of up to $122.5 million, as well as royalties on future product sales.
Other Collaboration Agreements
In addition to these contracts, we have entered into strategic collaborations with other third parties, including Phylaxis BioScience, LLC, or Phylaxis, Transcenta, and Elpiscience. For more information regarding these agreements, refer to Note 6 to the condensed consolidated financial statements.
Components of Results of Operations
Revenue
To date, all of our revenue has been derived from licenses with collaboration partners and grant awards. We have not generated any revenue from the commercial sale of approved therapeutic products, and until, if ever, they are approved for commercial sale, we expect our revenue will be derived primarily from payments under our current license agreements and any potential future collaborations or strategic transactions.
Operating Expenses
Research and Development
To date, our research and development expenses have related primarily to research activities, including our discovery efforts, and preclinical and clinical development and the manufacturing of our therapeutic candidates. Research and development expenses are recognized as incurred and payments made prior to the receipt of goods or services to be used in research and development are capitalized until the goods or services are received. We do not track our internal research and development expenses on a program-by-program basis as they primarily relate to personnel, early research and consumable costs, which are deployed across multiple projects under development.
Research and development expenses consist primarily of:
•External expenses, consisting of:
◦expenses incurred in connection with the preclinical development of our programs;
◦clinical trials of our therapeutic candidates, including under agreements with third parties, such as consultants and contract research organizations, or CROs;
◦expenses associated with the manufacturing of our therapeutic candidates under agreements with contract development and manufacturing organizations, or CDMOs;
◦expenses associated with regulatory requirements, including fees and other expenses related to our Scientific Advisory Board; and
◦other external expenses, such as laboratory services related to our discovery and development programs and other shared services, and
•Internal expenses, consisting of:
◦salaries, benefits and other related costs, including non-cash stock-based compensation, for personnel engaged in research and development functions;
◦facilities, depreciation and other expenses, which include direct and allocated expenses for depreciation and amortization, rent and maintenance of facilities; and
◦other internal expenses, such as laboratory supplies and other shared research and development costs.
We expect that research and development expense will continue to increase over the next several years as we continue development of our therapeutic candidates currently in clinical stage development, support our preclinical programs, and continue to discover new therapeutic candidates, as well as increase our headcount. In particular, clinical development of our therapeutic candidates, as opposed to preclinical development, generally has higher development costs, primarily due to the increased size and duration of later-stage clinical trials. Moreover, the costs associated with our CDMOs to manufacture our therapeutic candidates and future commercial products is also much more costly as compared to early stage preclinical development. We cannot determine with certainty the timing of initiation, the duration or the completion costs of current or future preclinical studies and clinical trials of our therapeutic candidates due to the inherently unpredictable nature of preclinical and clinical development. Preclinical and clinical development timelines, the probability of success and development costs can differ materially from expectations. We anticipate that we will make determinations as to which therapeutic candidates to pursue and how much funding to direct to each therapeutic candidate on an ongoing basis in response to the results of ongoing and future preclinical studies and clinical trials, regulatory developments and our ongoing assessments as to each therapeutic candidate’s commercial potential. We will need substantial additional capital in the future to support these efforts. In addition, we cannot forecast which therapeutic candidates may be subject to future collaborations, when such arrangements will be secured, if at all, and to what degree such arrangements would affect our development plans and capital requirements.
Our clinical development costs may vary significantly based on factors such as:
•the per patient trial costs;
•the number of trials required for approval;
•the number of sites included in the trials;
•the countries in which the trials are conducted;
•the length of time required to enroll eligible patients;
•the number of patients that participate in the trials;
•the number of doses that patients receive;
•the drop-out or discontinuation rates of patients;
•the potential additional safety monitoring requested by regulatory agencies;
•the duration of patient participation in the trials and follow-up;
•the cost, timing, and successful manufacturing of our therapeutic candidates;
•the phase and development of our therapeutic candidates;
•the efficacy and safety profile of our therapeutic candidates; and
•the uncertainties related to potential economic downturn, geopolitical events and widespread health events on capital and financial markets.
General and Administrative
General and administrative, or G&A, expenses consist primarily of:
•salaries, benefits and other related costs, including non-cash stock-based compensation, for personnel engaged in G&A functions;
•expenses incurred in connection with accounting and audit services, legal services, including costs associated with obtaining and maintaining our patent portfolio, investor relations and consulting expenses under agreements with third parties, such as consultants and contractors;
•expenses incurred in connection with commercialization and business development activity; and
•facilities, depreciation and other expenses, which include direct and allocated expenses for depreciation and amortization, rent and maintenance of facilities, insurance and supplies.
We expect our G&A expenses will continue to increase in the future to support our continued research and development activities. We expect increased costs related to pre-commercialization and business development activities, including the hiring of additional personnel as we continue to build our commercial team in preparation for our future product launches. Additionally, we expect other professional service fees to increase, including but not limited to, patent-related costs for filing, prosecution and maintenance of our product candidates, and compliance costs, accounting, legal, investor and public relations and additional personnel.
Other Income (Expense)
Interest expense. Interest expense consists of our interest on our loans with Oxford Finance LLC, or Oxford.
Interest income. Interest income consists of our interest earned on cash and cash equivalents, including our investments in highly liquid debt securities with original maturities of less than three months from our date of acquisition.
Results of Operations
Comparison of the Three Months Ended June 30, 2023 and June 30, 2022
The following table summarizes our condensed consolidated results of operations for each of the periods indicated (in thousands, except percentages):
| | | | | | | | | | | | | | | | | | | | | | | |
| THREE MONTHS ENDED JUNE 30, | | CHANGE |
| 2023 | | 2022 | | ($) | | (%) |
| | | | | |
Revenue: | | | | | | | |
License fee revenue | $ | 30 | | | $ | 711 | | | $ | (681) | | | (96) | % |
| | | | | | | |
Total revenue | 30 | | | 711 | | | (681) | | | (96) | % |
Operating expense: | | | | | | | |
Research and development | 34,106 | | | 29,906 | | | 4,200 | | | 14 | % |
General and administrative | 7,263 | | | 5,402 | | | 1,861 | | | 34 | % |
Total operating expense | 41,369 | | | 35,308 | | | 6,061 | | | 17 | % |
Loss from operations | (41,339) | | | (34,597) | | | (6,742) | | | 19 | % |
Other income (expense) | | | | | | | |
Interest expense | (7,905) | | | (3,202) | | | (4,703) | | | 147 | % |
Interest income | 2,414 | | | 54 | | | 2,360 | | | 4,370 | % |
Other income (expense), net | (217) | | | 17 | | | (234) | | | (1,376) | % |
| | | | | | | |
| | | | | | | |
Total other expense | (5,708) | | | (3,131) | | | (2,577) | | | 155 | % |
Provision for income taxes | 5 | | | 4 | | | 1 | | | 25 | % |
| | | | | | | |
Net loss | $ | (47,052) | | | $ | (37,732) | | | $ | (9,320) | | | 31 | % |
License Fee Revenue
During the three months ended June 30, 2023 and 2022, we recognized $30,000 and $0.1 million, respectively, of license fee revenue related to the Chiesi Option Agreement. This decrease in revenue earned during the three months ended June 30, 2023 is due to the timing of the performance of CDMO and CRO services in relation to the Phase 1 clinical trial for INBRX-101. Additionally, during the three months ended June 30, 2022 we recognized license fee revenue of approximately $0.4 million related to our agreements with Phylaxis. Work on the first phase of this agreement was completed and all deferred revenue was recognized during 2022. Accordingly, no revenue was recognized under our agreements with Phylaxis during the three months ended June 30, 2023. We also recognized $0.2 million of revenue under the 2020 2seventy Agreement following the grant of an exclusive option and development license upon initiation of a third program during the three months ended June 30, 2022. No revenue was recognized under this agreement with 2seventy during the three months ended June 30, 2023.
Research and Development Expense
The following table sets forth the primary external and internal research and development expenses (in thousands, except percentages): | | | | | | | | | | | | | | | | | | | | | | | |
| THREE MONTHS ENDED JUNE 30, | | CHANGE |
| 2023 | | 2022 | | ($) | | (%) |
| | | | | |
External expenses: | | | | | | | |
Clinical trials | $ | 11,548 | | | $ | 9,503 | | | $ | 2,045 | | | 22 | % |
Contract manufacturing | 5,019 | | | 7,059 | | | (2,040) | | | (29) | % |
| | | | | | | |
Other external research and development | 2,014 | | | 1,744 | | | 270 | | | 15 | % |
Internal expenses: | | | | | | | |
Personnel | 12,095 | | | 8,821 | | | 3,274 | | | 37 | % |
Equipment, depreciation, and facility | 1,736 | | | 1,520 | | | 216 | | | 14 | % |
Other internal research and development | 1,694 | | | 1,259 | | | 435 | | | 35 | % |
Total research and development expenses | $ | 34,106 | | | $ | 29,906 | | | $ | 4,200 | | | 14 | % |
Research and development expenses increased by $4.2 million from $29.9 million during the three months ended June 30, 2022 to $34.1 million during the three months ended June 30, 2023. The overall increase was primarily due to the following factors:
•clinical trial expense increased by $2.0 million due to costs incurred upon the initiation of the registration-enabling Phase 2 trial for INBRX-101 for the treatment of emphysema due to AATD, as well as the progression of our INBRX-109 registration-enabling Phase 2 trial for the treatment of unresectable or metastatic conventional chondrosarcoma. Costs associated with our Phase 1/2 clinical trials for INBRX-105 and INBRX-106 remained consistent in each period;
•contract manufacturing expense decreased by $2.0 million, due to the nature of development and manufacturing activities performed during each period at our CDMO partners supporting our clinical and preclinical therapeutic candidates, which reflect the stage-specific needs of our programs and include early and late stage drug substance clinical manufacturing, analytical development, QC testing and stability studies, as well as drug product development, scale-up, robustness studies and selected BLA-enabling activities;
•personnel-related expense increased by $3.3 million, which was primarily related to an increase in headcount as a result of a significant expansion of our clinical operations team, as well as the issuance of additional stock options and the expansion of the bonus eligibility pool during the current year;
•facility and equipment-related expense increased by $0.2 million, which was primarily attributable to an increase in software subscriptions to support research and development activities and repairs and maintenance services; and
•other research and development expense increased by $0.7 million, which was primarily attributable to an increase in travel expenses to clinical and vendor sites, clinical-related consulting expenses, and preclinical studies.
G&A Expense
G&A expenses increased by $1.9 million from $5.4 million during the three months ended June 30, 2022 to $7.3 million during the three months ended June 30, 2023. The overall increase during the three months ended June 30, 2023 was primarily due to the following factors:
•personnel-related expenses increased by $1.2 million, primarily attributable to an increase in headcount as we continue to build out our commercial strategy and medical affairs team, as well as increased expense
related to additional stock option grants to employees and the expansion of the bonus eligibility pool in the current year;
•pre-commercialization expenses increased by $0.5 million, primarily related to market research expenses related to INBRX-101 and INBRX-109, and other expenses incurred related to scientific publications; and
•facility and equipment-related expense increased by $0.2 million, which was primarily attributable to increases in software subscriptions and IT services.
Other income (expense)
Interest expense. Interest expense increased by $4.7 million from $3.2 million during the three months ended June 30, 2022 to $7.9 million during the three months ended June 30, 2023. During the three months ended June 30, 2023, we recorded $7.9 million of interest expense related to interest incurred and the amortization of debt discounts related to the Amended 2020 Loan Agreement, under which we had an outstanding principal balance of $200.0 million as of June 30, 2023. During the three months ended June 30, 2022, we incurred $3.2 million of interest expense related to interest incurred and the amortization of debt discounts related to the Amended 2020 Loan Agreement, under which we had an outstanding principal balance of $170.0 million as of June 30, 2022. For more information regarding the Amended 2020 Loan Agreement, refer to Note 3 to the condensed consolidated financial statements.
Interest income. During the three months ended June 30, 2023, we earned $2.4 million of interest income and the accretion of discounts on investments in debt securities during the period. During the three months ended June 30, 2022, we earned $0.1 million of interest income.
Comparison of the Six Months Ended June 30, 2023 and June 30, 2022
The following table summarizes our condensed consolidated results of operations for each of the periods indicated (in thousands, except percentages):
| | | | | | | | | | | | | | | | | | | | | | | |
| SIX MONTHS ENDED JUNE 30, | | CHANGE |
| 2023 | | 2022 | | ($) | | (%) |
| | | | | |
Revenue: | | | | | | | |
License fee revenue | $ | 47 | | | $ | 1,626 | | | $ | (1,579) | | | (97) | % |
Grant revenue | — | | | 14 | | | (14) | | | (100) | % |
Total revenue | 47 | | | 1,640 | | | (1,593) | | | (97) | % |
Operating expense: | | | | | | | |
Research and development | 71,492 | | | 54,801 | | | 16,691 | | | 30 | % |
General and administrative | 13,660 | | | 10,453 | | | 3,207 | | | 31 | % |
Total operating expense | 85,152 | | | 65,254 | | | 19,898 | | | 30 | % |
Loss from operations | (85,105) | | | (63,614) | | | (21,491) | | | 34 | % |
Other income (expense) | | | | | | | |
Interest expense | (15,468) | | | (5,520) | | | (9,948) | | | 180 | % |
Interest income | 4,897 | | | 98 | | | 4,799 | | | 4897 | % |
Other income, net | (287) | | | 54 | | | (341) | | | (631) | % |
| | | | | | | |
| | | | | | | |
Total other expense | (10,858) | | | (5,368) | | | (5,490) | | | 188 | % |
Provision for income taxes | 5 | | | 4 | | | 1 | | | 25 | % |
| | | | | | | |
Net loss | $ | (95,968) | | | $ | (68,986) | | | $ | (26,982) | | | 46 | % |
License Fee Revenue
During the six months ended June 30, 2023 and June 30, 2022, we recognized $47,000 and $0.3 million, respectively, of license fee revenue related to the Chiesi Option Agreement. This decrease in revenue earned during the six months ended June 30, 2023 is due to the timing of the performance of CDMO and CRO services in relation to the Phase 1 clinical trial for INBRX-101. Additionally, during the six months ended June 30, 2022 we recognized license fee revenue of approximately $1.1 million related to our agreements with Phylaxis. Work on the first phase of this agreement was completed and all deferred revenue was recognized during 2022. Accordingly, no revenue was recognized under our agreements with Phylaxis during the six months ended June 30, 2023.We also recognized $0.2 million of revenue under the 2020 2seventy Agreement following the grant of an exclusive option and development license upon initiation of a third program during the six months ended June 30, 2022. No revenue was recognized under this agreement with 2seventy during the six months ended June 30, 2023.
Research and Development Expense
The following table sets forth the primary external and internal research and development expenses (in thousands, except percentages):
| | | | | | | | | | | | | | | | | | | | | | | |
| SIX MONTHS ENDED JUNE 30, | | CHANGE |
| 2023 | | 2022 | | ($) | | (%) |
| | | | | |
External expenses: | | | | | | | |
Clinical trials | $ | 21,567 | | | $ | 14,510 | | | $ | 7,057 | | | 49 | % |
Contract manufacturing | 15,346 | | | 13,952 | | | 1,394 | | | 10 | % |
| | | | | | | |
Other external research and development | 4,300 | | | 3,822 | | | 478 | | | 13 | % |
Internal expenses: | | | | | | | |
Personnel | 23,397 | | | 17,249 | | | 6,148 | | | 36 | % |
Equipment, depreciation, and facility | 3,534 | | | 2,903 | | | 631 | | | 22 | % |
Other internal research and development | 3,348 | | | 2,365 | | | 983 | | | 42 | % |
Total research and development expenses | $ | 71,492 | | | $ | 54,801 | | | $ | 16,691 | | | 30 | % |
Research and development expenses increased by $16.7 million from $54.8 million during the six months ended June 30, 2022 to $71.5 million during the six months ended June 30, 2023. The overall increase was primarily due to the following factors:
•clinical trial expense increased by $7.1 million due to costs incurred upon the initiation of the registration-enabling Phase 2 trial for INBRX-101 for the treatment of emphysema due to AATD, as well as the progression of our INBRX-109 registration-enabling Phase 2 trial for the treatment of unresectable or metastatic conventional chondrosarcoma. Costs associated with our Phase 1/2 clinical trials for INBRX-105 and INBRX-106 remained consistent in each period;
•contract manufacturing expense increased by $1.4 million due to greater development and manufacturing costs at our CDMO partners supporting our clinical and preclinical therapeutic candidates, including early and late stage drug substance clinical manufacturing, analytical development, QC testing, and stability studies, as well as drug product development, scale-up, robustness studies, and selected BLA-enabling activities;
•personnel-related expense increased by $6.1 million, primarily related to an increase in headcount as a result of a significant expansion of our clinical operations team, as well as the issuance of additional stock options and the expansion of the bonus eligibility pool during the current year;
•facility and equipment-related expense increased by $0.6 million, which was attributable to an increase in software subscriptions to support research and development activities and repairs and maintenance services; and
•other research and development expense increased by $1.5 million, which was primarily attributable to an increase in travel expenses to clinical and vendor sites, clinical-related consulting expenses, lab supplies, and preclinical studies.
G&A Expense
G&A expenses increased by $3.2 million from $10.5 million during the six months ended June 30, 2022 to $13.7 million during the six months ended June 30, 2023. The overall increase during the six months ended June 30, 2023, was primarily due to the following factors:
•personnel-related expenses increased by $2.3 million, related to an increase in headcount primarily due to building out our commercial strategy and medical affairs team, additional stock option grants to employees, and the expansion of the bonus eligibility pool in the current year;
•pre-commercialization expenses increased by $0.6 million, primarily related to market research expenses related to INBRX-101 and INBRX-109, and other expenses incurred in relation to scientific publications; and
•facility and equipment-related expense increased by $0.3 million, which was primarily attributable to an increase in software subscriptions and IT services.
Other Expense
Interest expense. Interest expense increased by $10.0 million to $15.5 million during the six months ended June 30, 2023 from $5.5 million during the six months ended June 30, 2022. During the six months ended June 30, 2023, we recorded $15.5 million of interest related to interest paid and the amortization of debt discounts related to the Amended 2020 Loan Agreement, under which we had an outstanding principal balance of $200.0 million as of June 30, 2023. During the six months ended June 30, 2022, we recorded $5.5 million of interest related to interest paid and the amortization of debt discounts related to the Amended 2020 Loan Agreement, under which we had an outstanding principal balance of $170.0 million as of June 30, 2022. For more information regarding the Amended 2020 Loan Agreement, refer to Note 3 to the condensed consolidated financial statements.
Interest income. During the six months ended June 30, 2023, we earned $4.9 million of interest income and the accretion of discounts on investments in debt securities during the period. During the six months ended June 30, 2022, we earned $0.1 million of interest income.
Liquidity, Capital Resources and Financial Condition
Sources of Liquidity
To date, sources of capital raised to fund our operations have been comprised of the sale of equity securities, borrowings under the loan and security agreements, payments received from commercial partners for licensing rights to our therapeutic candidates under development and grants and proceeds from the sale and issuance of convertible promissory notes.
Through June 30, 2023, proceeds from the sale of equity securities as a public company consisted of $125.9 million in net proceeds from our initial public offering and $167.6 million in net proceeds under our Open Market Sale Agreement, or the Sales Agreement, with Jefferies LLC, or the Sales Agent. Under the Sales Agreement, which we entered into in September 2021, we may, from time to time, sell shares of common stock through the Sales Agent with an aggregate offering price of up to $200.0 million, of which we have sold $171.4 million in gross proceeds to date as of June 30, 2023 and December 31, 2022. Sales of our common stock made pursuant to the Sales Agreement have been made under our $400.0 million Shelf Registration on Form S-3ASR, which became automatically effective upon filing on September 3, 2021.
Borrowings under loan and security agreements consist of the Amended 2020 Loan Agreement with Oxford, under which we received $200.0 million in gross proceeds in seven tranches between July 2020 and October 2022.
Other sources of capital raised to fund our operations have been comprised of payments received from commercial partners for licensing rights to our therapeutic candidates under development and grant revenue.
Future Funding Requirements
Since our inception, we have devoted substantially all of our efforts to therapeutic drug discovery and development, conducting preclinical studies and clinical trials, enabling manufacturing activities in support of our therapeutic candidates, establishing our intellectual property portfolio, developing our commercialization strategy, hiring to support these departments and activities and raising capital to support and expand these activities. Cash used to fund operating expenses is impacted by the timing of when we pay these expenses, as reflected in the change in our outstanding accounts payable and accrued expenses. Our net losses may fluctuate significantly from quarter-to-quarter and year-to-year, depending on the timing of our clinical trials and our expenditures on other research and development activities.
Our net loss for the six months ended June 30, 2023 and June 30, 2022 was $96.0 million and $69.0 million, respectively. As of June 30, 2023, we had an accumulated deficit of $468.3 million and cash and cash equivalents of $192.5 million. Based upon our current operating plans, we believe that our existing cash and cash equivalents will be sufficient to fund our operations for at least the next 12 months from the date these condensed consolidated
financial statements are issued. Our forecast of the period of time through which our financial resources will be adequate to support our operations is a forward-looking statement that involves risks and uncertainties, and actual results could vary materially. We have based this estimate on assumptions that may prove to be wrong, and we could deplete our capital resources sooner than we expect.
The process of conducting preclinical studies and testing product candidates in clinical trials is costly, and the timing of progress and expenses in these studies and trials is uncertain. We expect to continue to incur net losses for the foreseeable future until, if ever, we have an approved product and can successfully commercialize it. We expect our research and development expenses to increase as we continue our development of, and seek marketing approvals for, our therapeutic candidates (especially as we move more candidates into later stages of clinical development), and begin to commercialize any approved products, if ever. At this time, we are preparing to proceed with the commercialization of certain of our product candidates, if ever approved. As a result, we will incur significant pre-commercialization expenses in preparation for launch, the outcome of which is uncertain. Additionally, if approved, we will incur significant commercialization expenses related to product sales, marketing, manufacturing, and distribution. We also expect additional general and administrative expenses as we hire additional personnel and incur increased accounting, audit, legal, regulatory and compliance, investor and public relations expense.
Until such time, if ever, we can generate substantial product revenue, we expect to finance our cash needs through equity offerings, debt financings or other capital sources, including strategic licensing and collaborations, strategic transactions, or other similar arrangements and transactions, and from time to time, we engage in discussions with potential acquirers regarding the disposition of one or more of our product candidates. However, there can be no assurance as to the availability or terms upon which such finances or capital might be available in the future. If we are unable to secure adequate additional funding, we will need to reevaluate our operating plan and may be forced to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible, delay, scale back or eliminate some or all of our development programs, or relinquish rights to our intellectual property on less favorable terms than we would otherwise choose. These actions could materially impact our business, results of operations, financial condition, and prospects.
Our future liquidity and capital funding requirements will depend on numerous factors, including:
•the outcome, costs and timing of preclinical studies and clinical trials for our current or future therapeutic candidates;
•whether and when we are able to obtain marketing approval to market any of our therapeutic candidates and the outcome of meetings with applicable regulatory agencies, including the FDA;
•our ability to successfully commercialize any therapeutic candidates that receive marketing approval;
•the emergence and effect of competing or complementary therapeutics or therapeutic candidates;
•our ability to maintain, expand and defend the scope of our intellectual property portfolio, including the amount and timing of any payments we may be required to make, or that we may receive, in connection with the licensing, filing, prosecution, defense and enforcement of any patents or other intellectual property rights;
•our ability to retain our current employees and the need and ability to hire additional management and scientific and medical personnel;
•the terms and timing of any strategic licensing, collaboration or other similar agreement that we have established or may establish;
•our ability to repay, refinance or restructure our indebtedness when payment is due, including in the event such indebtedness is accelerated;
•the valuation of our capital stock; and
•the continuing or future effects of a potential economic downturn, geopolitical events and widespread health events on capital and financial markets.
We do not own or operate manufacturing and testing facilities for the production of any of our therapeutic candidates, nor do we have plans to develop our own manufacturing operations in the foreseeable future. We currently rely on a limited number of third-party contract manufacturers for all of our required raw materials, antibodies and other biologics for our preclinical research, clinical trials, and if and when applicable, commercial product, and employ internal resources to manage our manufacturing relationships with these third parties.
Commitments
Our material cash requirements from known contractual and other obligations primarily relate to our lease obligations, debt, and services provided by our third party CROs, and CDMOs.
We have two leases for our laboratory and office space, which expire in 2025, with an option to extend the leases for an additional five years. As of June 30, 2023, we have future minimum rental payments under these leases of $4.5 million, of which $2.2 million and $2.3 million are current and non-current, respectively. For more information regarding these lease agreements, refer to Note 7 to the condensed consolidated financial statements.
Under the Amended 2020 Loan Agreement, we are required to make interest only payments through February 2025, with all principal payments and final fee payments beginning in March 2025, unless the Amended 2020 Loan Agreement is extended an additional twelve months upon a qualified financing event, and continuing through the maturity date of January 2027. As of June 30, 2023, we have a minimum obligation of $265.1 million of long-term debt, including minimum interest and final fee payments, of which $17.7 million and $247.4 million are current and non-current, respectively. For more information regarding the Amended 2020 Loan Agreement, refer to Note 3 to the condensed consolidated financial statements.
We enter into contracts in the normal course of business with CROs related to our ongoing preclinical studies and clinical trials and with CDMOs for clinical supplies and manufacturing scale-up activities. These contracts are generally cancellable, with notice, at our option. We have recorded accrued expenses of approximately $12.9 million in our condensed consolidated balance sheets for expenditures incurred by CROs and CDMOs as of June 30, 2023.
While these contracts are generally cancellable, some may contain specific activities that involve one or more non-cancellable commitments, including minimum purchase commitments, binding annual forecasts and capital equipment investments. Additionally, depending on the timing and reasoning of the exit, certain termination penalties may apply and can range from the cost of work performed to date up to twelve months of future committed manufacturing costs. As of June 30, 2023, the non-cancellable portion of these contracts total in aggregate, excluding amounts recorded in accounts payable and accrued expenses as of this date is approximately $76.5 million. The non-cancellable purchase commitments relate to the purchase of raw materials and future contract manufacturing of drug supply for INBRX-101.
Cash Flow Summary
The following table sets forth a summary of the net cash flow activity for each of the periods indicated (in thousands):
| | | | | | | | | | | | | | |
| | SIX MONTHS ENDED JUNE 30, |
| | 2023 | | 2022 |
| | |
Net cash used in operating activities | | $ | (82,243) | | | $ | (53,863) | |
Net cash used in investing activities | | (340) | | | (439) | |
Net cash provided by financing activities | | 1,210 | | | 99,386 | |
Net increase (decrease) in cash and cash equivalents | | $ | (81,373) | | | $ | 45,084 | |
Operating Activities
Net cash used in operating activities was $82.2 million during the six months ended June 30, 2023 and consisted primarily of a net loss of $96.0 million, adjusted for non-cash items including accretion on our debt discount and the non-cash portion of interest expense related to our debt of $2.4 million, stock-based compensation expense of $11.9 million, depreciation and amortization of $0.6 million and non-cash lease expense of $0.9 million. Changes in operating assets and liabilities also contributed to the cash used in operating activities, primarily related to an increase in prepaid expenses and other current assets of $4.1 million, offset in part by increases in accrued expenses and other current liabilities of $2.3 million and accounts payable of $0.8 million, primarily due to the timing of payments to our CRO and CDMO partners during the period. Additionally, the operating lease liability decreased by $0.9 million as a result of lease payments made throughout the period.
Net cash used in operating activities was $53.9 million during the six months ended June 30, 2022 and consisted primarily of a net loss of $69.0 million, adjusted for non-cash items including accretion on our debt discount and the non-cash portion of interest expense related to our debt of $1.2 million, stock-based compensation expense of $10.4 million, depreciation and amortization of $0.6 million, and non-cash lease expense of $0.8 million. Changes in operating assets and liabilities also contributed to the cash used in operating activities, primarily related to decreases in prepaid expenses and other current assets of $2.0 million and accrued expenses and other current liabilities of $2.9 million due to the timing of clinical activity and contract manufacturing work performed by our CDMO partners. These were offset by increases in other non-current assets of $1.3 million relating to deposits paid to one of our CRO partners. Additionally, deferred revenue decreased by $1.4 million upon the recognition of revenue under our option and license agreements and the operating lease liability decreased by $0.8 million.
Investing Activities
Net cash used in investing activities was $0.3 million and $0.4 million during the six months ended June 30, 2023 and June 30, 2022, respectively, and was related to capital purchases of laboratory and office equipment.
Financing Activities
Net cash provided by financing activities was $1.2 million during the six months ended June 30, 2023, which consisted of proceeds upon the exercise of stock options.
Net cash provided by financing activities was $99.4 million during the six months ended June 30, 2022 and consisted primarily of approximately $98.9 million of proceeds from Oxford under the Amended 2020 Loan Agreement upon draw of the Term D loan in February 2022 and the Term E and Term F loans in June 2022. Additionally, we received approximately $0.6 million of proceeds upon the exercise of stock options.
Critical Accounting Estimates and Policies
Our management’s discussion and analysis of our financial condition and results of operations is based on our condensed consolidated financial statements, which have been prepared in accordance with accounting principles generally accepted in the United States of America. The preparation of financial statements requires us to make estimates and judgements that affect the reported amounts of assets, liabilities, revenues, costs and expenses and related disclosures. We base our estimates on historical experience and on various other assumptions that we believe
to be reasonable under the circumstances. Changes in estimates are reflected in reported results for the period in which they become known. Actual results could differ significantly from the estimates made by our management.
There have been no material changes to our critical accounting policies and estimates from those disclosed in our financial statements and the related notes and other financial information included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022.
Recent Accounting Pronouncements
See Note 1 to our condensed consolidated financial statements included elsewhere in this Quarterly Report for a discussion of recent accounting pronouncements and their effect, if any, on us.
Item 3. Quantitative and Qualitative Disclosures about Market Risks.
We are a smaller reporting company as defined by Rule 12b-2 of the Securities Exchange Act of 1934, as amended, or the Exchange Act, and are not required to provide the information required under this item.
Item 4. Controls and Procedures.
Evaluation of Disclosure Controls and Procedures
We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in our reports filed pursuant to the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including our principal executive officer and principal financial and accounting officer, as appropriate, to allow timely decisions regarding required disclosure.
Our management, with the participation and supervision of our Chief Executive Officer and our Chief Financial Officer, evaluated the effectiveness of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act) as of the end of the period covered by this Quarterly Report. Based on that evaluation, our Chief Executive Officer and our Chief Financial Officer have concluded that, as of the end of the period covered by this Quarterly Report, our disclosure controls and procedures were designed and operating effectively at the reasonable assurance level.
Changes in Internal Control over Financial Reporting
There were no changes in our internal control over financial reporting that occurred during the quarter ended June 30, 2023 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
Inherent Limitations on Effectiveness of Controls
Our management, including our Chief Executive Officer and our Chief Financial Officer, does not expect that our disclosure controls or our internal control over financial reporting will prevent or detect all error and all fraud. A control system, no matter how well designed and operated, can provide only reasonable and not absolute assurance of achieving the desired control objectives. In reaching a reasonable level of assurance, management necessarily was required to apply its judgment in evaluating the benefits of possible controls and procedures relative to their costs. Controls can also be circumvented by the individual acts of some persons, by collusion of two or more people, or by management override of the controls. In addition, the design of any system of controls is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions. Over time, controls may become inadequate because of changes in conditions or deterioration in the degree of compliance with policies or procedures.
Part II — Other Information
Item 1. Legal Proceedings.
We are not currently a party to any material legal proceedings. From time to time, we may become involved in legal proceedings arising in the ordinary course of our business. Regardless of outcome, litigation can have an adverse impact on us due to defense and settlement costs, diversion of management resources, negative publicity, reputational harm and other factors.
Item 1A. Risk Factors.
There have been no material changes to the risk factors set forth in Part I, Item 1A of our Annual Report on Form 10-K for the fiscal year ended December 31, 2022 and in Part II, Item 1A of our Quarterly Report on Form 10-Q for the three months ended March 31, 2023.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
None.
Item 3. Defaults Upon Senior Securities.
None.
Item 4. Mine Safety Disclosures.
Not applicable.
Item 5. Other Information.
None.
Item 6. Exhibits.
(a) Exhibits.
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Exhibit No. | | Description of Exhibit | | Filed Herewith | | Form | | Incorporated By Reference File No. | | Date Filed |
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* This certification is deemed not filed for purpose of section 18 of the Exchange Act or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act or the Exchange Act.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
| | | | | | | | |
| | INHIBRX, INC. |
| | |
Date: August 7, 2023 | | /s/ Mark P. Lappe |
| | Mark P. Lappe |
| | Chief Executive Officer and Chairman |
| | (Principal Executive Officer) |
| | |
Date: August 7, 2023 | | /s/ Kelly D. Deck |
| | Kelly D. Deck, C.P.A. |
| | Chief Financial Officer |
| | (Principal Financial and Accounting Officer) |
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
I, Mark P. Lappe, certify that:
1.I have reviewed this Quarterly Report on Form 10-Q of Inhibrx, Inc;
2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
a.Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b.Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c.Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d.Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
a.All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
b.Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
| | | | | | | | |
Date: August 7, 2023 | | /s/ Mark P. Lappe |
| | Mark P. Lappe |
| | Chief Executive Officer and Chairman |
| | (Principal Executive Officer) |
CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002
I, Kelly D. Deck, certify that:
1.I have reviewed this Quarterly Report on Form 10-Q of Inhibrx, Inc;
2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
a.Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b.Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c.Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d.Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
a.All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
b.Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
| | | | | | | | |
Date: August 7, 2023 | | /s/ Kelly D. Deck |
| | Kelly D. Deck, C.P.A. |
| | Chief Financial Officer |
| | (Principal Financial and Accounting Officer) |
CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the quarterly report of Inhibrx, Inc. (the “Company”) on Form 10-Q for the quarter ended June 30, 2023, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Mark P. Lappe, Chief Executive Officer and Chairman of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to my knowledge:
1.The Report fully complies with the requirements of Section 13(a) or 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and
2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
| | | | | | | | |
Date: August 7, 2023 | | /s/ Mark P. Lappe |
| | Mark P. Lappe |
| | Chief Executive Officer and Chairman |
| | (Principal Executive Officer) |
The foregoing certification is being furnished solely pursuant to 18 U.S.C. Section 1350 and is not being filed as part of the Report or as a separate disclosure document.
CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the quarterly report of Inhibrx, Inc. (the “Company”) on Form 10-Q for the quarter ended June 30, 2023, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Kelly D. Deck, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to my knowledge:
1.The Report fully complies with the requirements of Section 13(a) or 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and
2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
| | | | | | | | |
Date: August 7, 2023 | | /s/ Kelly D. Deck |
| | Kelly D. Deck, C.P.A. |
| | Chief Financial Officer |
| | (Principal Financial and Accounting Officer) |
The foregoing certification is being furnished solely pursuant to 18 U.S.C. Section 1350 and is not being filed as part of the Report or as a separate disclosure document.
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v3.23.2
Condensed Consolidated Balance Sheets - USD ($) $ in Thousands |
Jun. 30, 2023 |
Dec. 31, 2022 |
Current assets: |
|
|
Cash and cash equivalents |
$ 192,492
|
$ 273,865
|
Prepaid expenses and other current assets |
10,502
|
6,371
|
Total current assets |
203,321
|
280,493
|
Property and equipment, net |
2,832
|
2,501
|
Right-of-use asset |
3,853
|
4,717
|
Other non-current assets |
3,164
|
3,164
|
Total assets |
213,170
|
290,875
|
Current liabilities: |
|
|
Accounts payable |
9,700
|
8,326
|
Accrued expenses |
19,551
|
17,224
|
Deferred revenue |
119
|
166
|
Current portion of lease liability |
1,959
|
1,860
|
Total current liabilities |
31,329
|
27,576
|
Long-term debt, including final payment fee |
204,482
|
202,069
|
Non-current portion of lease liability |
2,171
|
3,173
|
Total liabilities |
237,982
|
232,818
|
Commitments and contingencies (Note 7) |
|
|
Stockholders’ equity (deficit) |
|
|
Preferred stock, $0.0001 par value; 15,000,000 shares authorized as of June 30, 2023 and December 31, 2022; no shares issued or outstanding as of June 30, 2023 and December 31, 2022. |
0
|
0
|
Common stock, $0.0001 par value; 120,000,000 shares authorized as of June 30, 2023 and December 31, 2022; 43,667,374 and 43,564,283 issued and outstanding as of June 30, 2023 and December 31, 2022, respectively. |
4
|
4
|
Additional paid-in-capital |
443,525
|
430,426
|
Accumulated deficit |
(468,341)
|
(372,373)
|
Total stockholders’ equity (deficit) |
(24,812)
|
58,057
|
Total liabilities and stockholders’ equity (deficit) |
213,170
|
290,875
|
Nonrelated Party |
|
|
Current assets: |
|
|
Accounts receivable |
327
|
243
|
Related Party |
|
|
Current assets: |
|
|
Accounts receivable |
$ 0
|
$ 14
|
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v3.23.2
Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares
|
Jun. 30, 2023 |
Dec. 31, 2022 |
Statement of Financial Position [Abstract] |
|
|
Preferred stock, par value (in dollars per share) |
$ 0.0001
|
$ 0.0001
|
Preferred stock, shares authorized (in shares) |
15,000,000
|
15,000,000
|
Preferred stock, shares issued (in shares) |
0
|
0
|
Preferred stock, shares outstanding (in shares) |
0
|
0
|
Common stock, par value (in dollars per share) |
$ 0.0001
|
$ 0.0001
|
Common stock, shares authorized (in shares) |
120,000,000
|
120,000,000
|
Common stock, shares issued (in shares) |
43,667,374
|
43,564,283
|
Common stock, shares outstanding (in shares) |
43,667,374
|
43,564,283
|
X |
- DefinitionFace amount or stated value per share of common stock.
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v3.23.2
Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Revenue: |
|
|
|
|
Total revenue |
$ 30
|
$ 711
|
$ 47
|
$ 1,640
|
Operating expenses: |
|
|
|
|
Research and development |
34,106
|
29,906
|
71,492
|
54,801
|
General and administrative |
7,263
|
5,402
|
13,660
|
10,453
|
Total operating expenses |
41,369
|
35,308
|
85,152
|
65,254
|
Loss from operations |
(41,339)
|
(34,597)
|
(85,105)
|
(63,614)
|
Other income (expense): |
|
|
|
|
Interest expense |
(7,905)
|
(3,202)
|
(15,468)
|
(5,520)
|
Interest income |
2,414
|
54
|
4,897
|
98
|
Other income (expense), net |
(217)
|
17
|
(287)
|
54
|
Total other expense |
(5,708)
|
(3,131)
|
(10,858)
|
(5,368)
|
Loss before income tax expense |
(47,047)
|
(37,728)
|
(95,963)
|
(68,982)
|
Provision for income taxes |
5
|
4
|
5
|
4
|
Net loss |
$ (47,052)
|
$ (37,732)
|
$ (95,968)
|
$ (68,986)
|
Net loss per share, basic (in dollars per share) |
$ (1.08)
|
$ (0.97)
|
$ (2.20)
|
$ (1.77)
|
Net loss per share, diluted (in dollars per share) |
$ (1.08)
|
$ (0.97)
|
$ (2.20)
|
$ (1.77)
|
Weighted-average shares of common stock outstanding, basic (in shares) |
43,642
|
39,040
|
43,609
|
39,029
|
Weighted-average shares of common stock outstanding, diluted (in shares) |
43,642
|
39,040
|
43,609
|
39,029
|
License fee revenue |
|
|
|
|
Revenue: |
|
|
|
|
Total revenue |
$ 30
|
$ 711
|
$ 47
|
$ 1,626
|
Grant revenue |
|
|
|
|
Revenue: |
|
|
|
|
Total revenue |
$ 0
|
$ 0
|
$ 0
|
$ 14
|
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v3.23.2
Condensed Consolidated Statements of Stockholders’ Equity (Deficit) - USD ($) $ in Thousands |
Total |
Common Stock |
Additional Paid-In Capital |
Accumulated Deficit |
Beginning balance (in shares) at Dec. 31, 2021 |
|
38,991,000
|
|
|
Beginning balance at Dec. 31, 2021 |
$ 52,383
|
$ 4
|
$ 279,526
|
$ (227,147)
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
Stock-based compensation expense |
5,108
|
|
5,108
|
|
Issuance of shares upon exercise of stock options (in shares) |
|
35,000
|
|
|
Issuance of shares upon exercise of stock options |
401
|
|
401
|
|
Issuance of warrants |
712
|
|
712
|
|
Net loss |
(31,254)
|
|
|
(31,254)
|
Ending balance (in shares) at Mar. 31, 2022 |
|
39,026,000
|
|
|
Ending balance at Mar. 31, 2022 |
27,350
|
$ 4
|
285,747
|
(258,401)
|
Beginning balance (in shares) at Dec. 31, 2021 |
|
38,991,000
|
|
|
Beginning balance at Dec. 31, 2021 |
52,383
|
$ 4
|
279,526
|
(227,147)
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
Net loss |
(68,986)
|
|
|
|
Ending balance (in shares) at Jun. 30, 2022 |
|
39,041,000
|
|
|
Ending balance at Jun. 30, 2022 |
(4,922)
|
$ 4
|
291,207
|
(296,133)
|
Beginning balance (in shares) at Mar. 31, 2022 |
|
39,026,000
|
|
|
Beginning balance at Mar. 31, 2022 |
27,350
|
$ 4
|
285,747
|
(258,401)
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
Stock-based compensation expense |
5,296
|
|
5,296
|
|
Issuance of shares upon exercise of stock options (in shares) |
|
15,000
|
|
|
Issuance of shares upon exercise of stock options |
164
|
|
164
|
|
Net loss |
(37,732)
|
|
|
(37,732)
|
Ending balance (in shares) at Jun. 30, 2022 |
|
39,041,000
|
|
|
Ending balance at Jun. 30, 2022 |
$ (4,922)
|
$ 4
|
291,207
|
(296,133)
|
Beginning balance (in shares) at Dec. 31, 2022 |
43,564,283
|
43,564,000
|
|
|
Beginning balance at Dec. 31, 2022 |
$ 58,057
|
$ 4
|
430,426
|
(372,373)
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
Stock-based compensation expense |
5,636
|
|
5,636
|
|
Issuance of shares upon exercise of stock options (in shares) |
|
31,000
|
|
|
Issuance of shares upon exercise of stock options |
356
|
|
356
|
|
Net loss |
(48,916)
|
|
|
(48,916)
|
Ending balance (in shares) at Mar. 31, 2023 |
|
43,595,000
|
|
|
Ending balance at Mar. 31, 2023 |
$ 15,133
|
$ 4
|
436,418
|
(421,289)
|
Beginning balance (in shares) at Dec. 31, 2022 |
43,564,283
|
43,564,000
|
|
|
Beginning balance at Dec. 31, 2022 |
$ 58,057
|
$ 4
|
430,426
|
(372,373)
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
Issuance of shares upon exercise of stock options (in shares) |
103,000
|
|
|
|
Net loss |
$ (95,968)
|
|
|
|
Ending balance (in shares) at Jun. 30, 2023 |
43,667,374
|
43,667,000
|
|
|
Ending balance at Jun. 30, 2023 |
$ (24,812)
|
$ 4
|
443,525
|
(468,341)
|
Beginning balance (in shares) at Mar. 31, 2023 |
|
43,595,000
|
|
|
Beginning balance at Mar. 31, 2023 |
15,133
|
$ 4
|
436,418
|
(421,289)
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
Stock-based compensation expense |
6,253
|
|
6,253
|
|
Issuance of shares upon exercise of stock options (in shares) |
|
72,000
|
|
|
Issuance of shares upon exercise of stock options |
854
|
|
854
|
|
Net loss |
$ (47,052)
|
|
|
(47,052)
|
Ending balance (in shares) at Jun. 30, 2023 |
43,667,374
|
43,667,000
|
|
|
Ending balance at Jun. 30, 2023 |
$ (24,812)
|
$ 4
|
$ 443,525
|
$ (468,341)
|
X |
- DefinitionAmount of increase to additional paid-in capital (APIC) for recognition of cost for award under share-based payment arrangement.
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v3.23.2
Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Cash flows from operating activities |
|
|
Net loss |
$ (95,968)
|
$ (68,986)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Depreciation and amortization |
589
|
614
|
Accretion of debt discount and non-cash interest expense |
2,413
|
1,171
|
Stock-based compensation expense |
11,889
|
10,404
|
Non-cash lease expense |
864
|
793
|
Loss on disposal of fixed assets |
2
|
6
|
Changes in operating assets and liabilities: |
|
|
Accounts receivable |
(84)
|
130
|
Receivables from related parties |
14
|
464
|
Prepaid expenses and other current assets |
(4,131)
|
2,029
|
Other non-current assets |
0
|
(1,317)
|
Accounts payable |
792
|
216
|
Accrued expenses |
2,327
|
2,851
|
Operating lease liability |
(903)
|
(811)
|
Deferred revenue, current portion |
(47)
|
(1,317)
|
Deferred revenue, non-current portion |
0
|
(110)
|
Net cash used in operating activities |
(82,243)
|
(53,863)
|
Cash flows from investing activities |
|
|
Purchase of fixed assets |
(340)
|
(439)
|
Net cash used in investing activities |
(340)
|
(439)
|
Cash flows from financing activities |
|
|
Proceeds from the issuance of debt |
0
|
98,871
|
Payment of fees associated with debt |
0
|
(50)
|
Proceeds from the exercise of stock options |
1,210
|
565
|
Net cash provided by financing activities |
1,210
|
99,386
|
Net increase (decrease) in cash and cash equivalents |
(81,373)
|
45,084
|
Cash and cash equivalents at beginning of period |
273,865
|
131,301
|
Cash and cash equivalents at end of period |
192,492
|
176,385
|
Supplemental disclosure of cash flow information |
|
|
Cash paid for interest |
12,948
|
3,975
|
Cash paid for income taxes |
5
|
4
|
Supplemental schedule of non-cash investing and financing activities |
|
|
Payable for purchase of fixed assets |
582
|
0
|
Fair value of warrants issued to lender in conjunction with February 2022 Amendment |
$ 0
|
$ 712
|
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v3.23.2
ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
|
6 Months Ended |
Jun. 30, 2023 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES |
ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Organization Inhibrx, Inc., or the Company, or Inhibrx, is a clinical-stage biopharmaceutical company focused on developing a broad pipeline of novel biologic therapeutic candidates. The Company combines target biology with protein engineering, technologies, and research and development to design therapeutic candidates. The Company’s current pipeline is focused on oncology and orphan diseases. Basis of Presentation The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America, or GAAP, and applicable rules and regulations of the Securities and Exchange Commission, or the SEC, related to an interim report on the Form 10-Q. The unaudited condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiary. All intercompany accounts and transactions have been eliminated in consolidation. The unaudited interim condensed consolidated financial statements reflect all adjustments which, in the opinion of management, are necessary for a fair statement of the results for the periods presented. All such adjustments are of a normal and recurring nature. The operating results presented in these unaudited interim condensed consolidated financial statements are not necessarily indicative of the results that may be expected for any future periods. Certain information and note disclosures normally included in annual financial statements prepared in accordance with GAAP have been condensed or omitted. Accordingly, the accompanying unaudited interim condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the related notes thereto for the fiscal year ended December 31, 2022, which are included in the Company’s Annual Report on Form 10-K filed with the SEC on March 6, 2023. Liquidity As of June 30, 2023, the Company had an accumulated deficit of $468.3 million and cash and cash equivalents of $192.5 million. From its inception and through June 30, 2023, the Company has devoted substantially all of its efforts to therapeutic drug discovery and development, conducting preclinical studies and clinical trials, enabling manufacturing activities in support of its therapeutic candidates, pre-commercialization activities, organizing and staffing the Company, establishing its intellectual property portfolio and raising capital to support and expand these activities. The Company believes that its existing cash and cash equivalents will be sufficient to fund the Company’s operations for at least 12 months from the date these condensed consolidated financial statements are issued. The Company plans to finance its future cash needs through equity offerings, debt financings or other capital sources, including potential collaborations, licenses, strategic transactions and other similar arrangements. If the Company does raise additional capital through public or private equity or convertible debt offerings, the ownership interests of its existing stockholders will be diluted, and the terms of those securities may include liquidation or other preferences that adversely affect its stockholders’ rights. If the Company raises capital through additional debt financings, it may be subject to covenants limiting or restricting its ability to take specific actions, such as incurring additional debt or making certain capital expenditures. To the extent that the Company raises additional capital through strategic licensing, collaboration or other similar agreement, it may have to relinquish valuable rights to its therapeutic candidates, future revenue streams or research programs at an earlier stage of development or on less favorable terms than it would otherwise choose, or to grant licenses on terms that may not be favorable to the Company. There can be no assurance as to the availability or terms upon which such financing and capital might be available in the future. If the Company is unable to secure adequate additional funding, it will need to reevaluate its operating plan and may be forced to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible, delay, scale back or eliminate some or all of its development programs, or relinquish rights to its technology on less favorable terms than it would otherwise choose. These actions could materially impact its business, financial condition, results of operations and prospects. The rules and regulations of the SEC or any other regulatory agencies may restrict the Company’s ability to conduct certain types of financing activities, or may affect the timing of and amounts it can raise by undertaking such activities. Use of Estimates The preparation of these unaudited condensed consolidated financial statements in conformity with GAAP requires the Company to make estimates and judgments that affect the reported amounts of assets, liabilities, revenue and expense and the disclosure of contingent assets and liabilities in the Company’s financial statements and accompanying notes. The Company’s most significant estimates relate to evaluation of whether revenue recognition criteria have been met, accounting for development work and preclinical studies and clinical trials, determining the assumptions used in measuring stock-based compensation, the incremental borrowing rate estimated in relation to the Company’s operating lease, and valuation allowances for the Company’s deferred tax assets. The Company bases its estimates on historical experience, known trends and other market-specific or other relevant factors that it believes to be reasonable under the circumstances. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. The Company’s actual results may differ from these estimates under different assumptions or conditions. Cash and Cash Equivalents Cash and cash equivalents are comprised of cash held in financial institutions including readily available checking and money market accounts and highly liquid investments in debt securities with an original maturity of three months or less. As of June 30, 2023, the Company’s investments in debt securities consisted of U.S. Treasury Bills, all of which mature in the third quarter of 2023. As of June 30, 2023, these investments were recorded at their amortized cost of $133.7 million, which was adjusted for the amortization or accretion of premiums or discounts. Concentrations of Credit Risk Financial instruments that subject the Company to significant concentrations of credit risk consist primarily of cash and cash equivalents, including investments in debt securities. The Company maintains deposits in federally insured financial institutions in excess of federally insured limits by the Federal Deposit Insurance Corporation, or FDIC, of up to $250,000. The Company’s investment portfolio consists of investments in U.S. Treasury securities, in excess of Securities Investor Protection Corporation limits of up to $500,000 in securities. The Company’s cash management and investment policy limits investment instruments to investment-grade securities with the objective to preserve capital and to maintain liquidity until the funds can be used in operations. The Company has not experienced any losses in such accounts and believes it is not exposed to significant risk on its cash balances due to the financial condition of the depository institutions in which those deposits are held. Fair Value Measurements The Company determines the fair value measurements of applicable assets and liabilities based on a three-tier fair value hierarchy established by accounting guidance and prioritizes the inputs used in measuring fair value. These tiers include: •Level 1 - Quoted prices in active markets for identical assets or liabilities. •Level 2 - Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. •Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. In certain cases, the inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, the level in the fair value hierarchy within which the fair value measurement in its entirety falls has been determined based on the lowest level input that is significant to the fair value measurement in its entirety. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires judgment and considers factors specific to the asset or liability. The Company’s investments in debt securities consist of U.S. Treasury Bills, which are classified as Level 1 in the fair value hierarchy. Due to the short-term nature of these securities which are classified as cash equivalents, the amortized value approximates fair value and the Company does not remeasure these instruments at fair value. The Company’s outstanding debt and warrants are both classified as Level 2 in the fair value hierarchy. As of June 30, 2023 and December 31, 2022, the Company had no financial instruments measured at fair value on a recurring basis. Revenue Recognition The Company has generated revenue from its license and collaboration agreements with partners, as well as from grants from government agencies and private not-for-profit organizations. Collaborative Research, Development, and License Agreements The Company enters into collaborative agreements with partners which may include the transfer of licenses, options to license and the performance of research and development activities. The terms associated with these agreements may include one or more of the following: (1) license fees; (2) nonrefundable up-front fees; (3) payments for reimbursement of research costs; (4) payments associated with achieving specific development, regulatory or commercial milestones; and (5) royalties based on specified percentages of net product sales, if any. Payments received from customers are included in deferred revenue, allocated between current and non-current on the condensed consolidated balance sheet, until all revenue recognition criteria are met. Typically, license fees, non-refundable upfront fees and funding of research activities are considered fixed, while milestone payments, including option exercise fees, are identified as variable consideration, which is constrained and excluded from the transaction price. The Company will recognize revenue for sales-based royalty if and when a subsequent sale occurs. The Company applies significant judgment when making estimates and assumptions under these agreements, including evaluating whether contractual obligations represent distinct performance obligations, including the assessment of whether options represent material rights, determining whether there are observable standalone prices and allocating transaction price to performance obligations within a contract, assessing whether any licenses are functional or symbolic, determining when performance obligations have been met, and assessing the recognition of variable consideration. The Company evaluates each performance obligation to determine if it can be satisfied and recognized as revenue at a point in time or over time. Typically, performance obligations consisting of a transfer of a license or the achievement of milestones are recognized at a point in time upon the transfer, while performance obligations consisting of research activities are recognized over time using an input method which is representative of the Company’s efforts to fulfill the performance obligation, based on costs incurred with third-parties or internal labor hours performed. Accrued Research and Development and Clinical Trial Costs Research and development costs are expensed as incurred and include the cost of compensation and related expenses, as well as expenses for third parties who conduct research and development on the Company’s behalf, pursuant to development and consulting agreements in place. The Company’s preclinical studies and clinical trials are performed internally, by third party contract research organizations, or CROs, and/or clinical investigators. The Company also engages with contract development and manufacturing organizations, or CDMOs, for clinical supplies and manufacturing scale-up activities related to its therapeutic candidates. Invoicing from these third parties may be monthly based upon services performed or based upon milestones achieved. The Company accrues these expenses based upon its assessment of the status of each clinical trial and the work completed, and upon information obtained from the CROs and CDMOs. The Company’s estimates are dependent upon the timeliness and accuracy of data provided by the CROs and CDMOs regarding the status and cost of the studies. Costs incurred related to the Company’s purchases of in-process research and development for early-stage products or products that are not commercially viable and ready for use, or have no alternative future use, are charged to expense in the period incurred. Costs incurred related to the licensing of products that have not yet received marketing approval to be marketed, or that are not commercially viable and ready for use, or have no alternative future use, are charged to expense in the period incurred. Income Taxes Income taxes are accounted for under the asset and liability method. Deferred income taxes are recorded for temporary differences between financial statement carrying amounts and the tax basis of assets and liabilities. Deferred tax assets and liabilities reflect the tax rates expected to be in effect for the years in which the differences are expected to reverse. A valuation allowance is provided if it is more likely than not that some or all of the deferred tax assets will not be realized. Net Loss Per Share Basic net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding during the same period. Diluted net loss per share is computed by dividing net loss by the weighted average number of common and common equivalent shares outstanding during the same period. The Company excludes common stock equivalents from the calculation of diluted net loss per share when the effect is anti-dilutive. For purposes of the diluted net loss per share calculation, warrants for purchase of common stock and stock options are considered to be potentially dilutive securities. Accordingly, for the six months ended June 30, 2023 and June 30, 2022, there is no difference in the number of shares used to calculate basic and diluted shares outstanding. Potentially dilutive securities not included in the calculation of diluted net loss per share, because to do so would be anti-dilutive, are as follows (in thousands): | | | | | | | | | | | | | | | | | AS OF JUNE 30, | | | | 2023 | | 2022 | | | | | | | | | | | | | Outstanding stock options | 6,608 | | | 5,196 | | | | | | | | | | | | | | Warrants to purchase common stock | 47 | | | 47 | | | | | | | 6,655 | | | 5,243 | | | | | |
Segment Information The Company operates under one segment which develops biologic therapeutic candidates. Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker in making decisions regarding resource allocation and assessing performance. Recent Accounting Pronouncements From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board, or FASB, or other standard setting bodies. The Company believes that the impact of the recently issued accounting pronouncements that are not yet effective will not have a material impact on its condensed consolidated financial condition or results of operations upon adoption. Adoption of New Accounting Pronouncements In June 2016, the FASB issued Accounting Standards Update, or ASU, 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (Topic 326), which intends to improve financial reporting by requiring earlier recognition of credit losses on certain financial assets, such as held-to-maturity debt securities. Subsequent to the issuance of ASU 2016-13, the FASB issued several additional ASUs to clarify implementation guidance, provide narrow-scope improvements and provide additional disclosure guidance. The Company adopted ASU 2016-13 as of January 1, 2023, which did not result in a material impact on its condensed consolidated financial statements and related disclosures.
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v3.23.2
OTHER FINANCIAL INFORMATION
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6 Months Ended |
Jun. 30, 2023 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
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OTHER FINANCIAL INFORMATION |
OTHER FINANCIAL INFORMATION Prepaid Expense and Other Current Assets Prepaid expense and other current assets were comprised of the following (in thousands): | | | | | | | | | | | | | AS OF | | AS OF | | JUNE 30, 2023 | | DECEMBER 31, 2022 | Clinical trials (1) | $ | 6,835 | | | $ | 4,294 | | Clinical drug substance and product manufacturing (2) | 2,362 | | | 1,171 | | Outside research and development services (3) | 280 | | | 232 | | | | | | Licenses | 701 | | | 493 | | Other | 324 | | | 181 | | Prepaid expense and other current assets | $ | 10,502 | | | $ | 6,371 | |
(1) Relates primarily to the Company’s prepayments to third-party CROs for management of clinical trials and prepayments for drug supply to be used in combination with the Company’s therapeutics. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development. (2) Relates primarily to the Company’s usage of third-party CDMOs for clinical and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development. (3) Relates to the Company’s usage of third-parties for other research and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development. Property and Equipment, Net Property and equipment, net were comprised of the following (in thousands): | | | | | | | | | | | | | AS OF | | AS OF | | JUNE 30, 2023 | | DECEMBER 31, 2022 | | | | | Machinery and equipment | $ | 7,393 | | | $ | 7,023 | | Leasehold improvements | 441 | | | 441 | | Computer software | 53 | | | 53 | | Furniture, fixtures, and other | 527 | | | 524 | | Construction in process | 518 | | | — | | Total property and equipment | 8,932 | | | 8,041 | | Less: accumulated depreciation and amortization | (6,100) | | | (5,540) | | Property and equipment, net | $ | 2,832 | | | $ | 2,501 | |
Depreciation and amortization expense totaled $0.3 million for each of the three months ended June 30, 2023 and June 30, 2022, and $0.6 million for each of the six months ended June 30, 2023 and June 30, 2022 and consisted of the following (in thousands): | | | | | | | | | | | | | | | | | | | | | | | | | THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, | | 2023 | | 2022 | | 2023 | | 2022 | Research and development | $ | 242 | | | $ | 248 | | | $ | 479 | | | $ | 506 | | General and administrative | 53 | | | 59 | | | 110 | | | 108 | | Total depreciation and amortization expense | $ | 295 | | | $ | 307 | | | $ | 589 | | | $ | 614 | |
Accrued Expenses Accrued expenses were comprised of the following (in thousands): | | | | | | | | | | | | | AS OF | | AS OF | | JUNE 30, 2023 | | DECEMBER 31, 2022 | | | | | Clinical trials(1) | $ | 8,185 | | | $ | 4,527 | | Clinical drug substance and product manufacturing(2) | 3,335 | | | 5,381 | | Other outside research and development (3) | 1,397 | | | 1,164 | | Interest expense | 2,230 | | | 2,124 | | Compensation-related | 3,390 | | | 3,374 | | Professional fees | 674 | | | 428 | | | | | | Other | 340 | | | 226 | | Accrued expenses | $ | 19,551 | | | $ | 17,224 | |
(1) Relates primarily to the Company’s usage of third-party CROs for management of clinical trials. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development. (2) Relates primarily to the Company’s usage of third-party CDMOs for clinical and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development. (3) Relates to the Company’s usage of third-parties for other research and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development.
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- DefinitionThe entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity.
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v3.23.2
DEBT
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6 Months Ended |
Jun. 30, 2023 |
Debt Disclosure [Abstract] |
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DEBT |
DEBT 2020 Loan Agreement In July 2020, the Company entered into a loan and security agreement, or the 2020 Loan Agreement, with Oxford Finance LLC, or Oxford, pursuant to which it received $10.0 million in gross proceeds, or Term A. The 2020 Loan Agreement was subsequently amended in November 2020, or the November 2020 Amendment, upon which a second tranche in an aggregate principal amount of $20.0 million was funded, or Term B, and in June 2021, or the June 2021 Amendment, upon which a third tranche in an aggregate principal amount of $40.0 million was funded, or Term C. In February 2022, the Company entered into an additional amendment, or the February 2022 Amendment, to the 2020 Loan Agreement, collectively, the Amended 2020 Loan Agreement, upon which the Company received gross proceeds of $40.0 million, or Term D. The February 2022 Amendment also provided for an increase in the interest rate and for three future tranches of debt to be funded upon the achievement of certain milestones. In June 2022, the Company received additional gross proceeds of $30.0 million, or Term E, following the initiation of part 4 of the Phase 1/2 clinical trial of INBRX-105, as well as an additional $30.0 million in gross proceeds, or Term F, following the receipt of positive topline data from the Phase 1 clinical trial of INBRX-101. In October 2022, the Company entered into an amendment to the Amended 2020 Loan Agreement, or the October 2022 Amendment. The October 2022 Amendment amended the milestone terms of the last remaining tranche, Term G, under the Amended 2020 Loan Agreement to provide for the funding of $30.0 million upon the announcement of the regulatory path for INBRX-101 rather than upon the initiation of a registration-enabling clinical trial of INBRX-101. In October 2022, the Company met this milestone and drew the final tranche for additional gross proceeds of $30.0 million. The Company determined the November 2020, June 2021, February 2022, and October 2022 Amendments should be treated as modifications of the original 2020 Loan Agreement since the terms and resulting cash flows were not substantially changed upon each of the amendments. The Company will continue to amortize the existing debt discounts prior to modification through the Amended Maturity Date (as defined below). As of June 30, 2023, the Company had $200.0 million in gross principal outstanding in term loans under the Amended 2020 Loan Agreement. The outstanding term loans will mature on January 1, 2027, or the Amended Maturity Date, and bear interest at a floating per annum rate equal to the greater of (1) 8.30% or (2) the sum of (i) the 30 day U.S. Dollar LIBOR rate reported in The Wall Street Journal on the last business day of the month that immediately precedes the month in which the interest will accrue, plus (ii) 8.19%. Under the Amended 2020 Loan Agreement, the repayment schedule provides for interest-only payments through February 1, 2025, followed by 23 months of principal and interest payments, unless extended by a financing event as defined in the Amended 2020 Loan Agreement. In the event of a qualifying financing event in which the Company raises at least $100.0 million in upfront licensing or partnership proceeds by February 2025, the interest-only period may be extended an additional 12 months through February 1, 2026, which would then be followed by 11 months of equal payments of principal plus interest, beginning on March 1, 2026. Upon the Amended Maturity Date, a final payment of 9.0% of the original principal amount will be due to Oxford. This final payment of $18.0 million is being accreted over the life of the Amended 2020 Loan Agreement using the effective interest method. The Company has the option to prepay the outstanding balance of the term loans in full prior to the Amended Maturity Date, subject to a prepayment fee ranging from 1.0% to 3.0%, depending upon the timing of the prepayment. The Company’s outstanding debt balance under the Amended 2020 Loan Agreement consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands). | | | | | | | | | | | | | | | AS OF | | AS OF | | | | JUNE 30, 2023 | | DECEMBER 31, 2022 | | | Term A | $ | 10,900 | | | $ | 10,900 | | | | Term B | 21,800 | | | 21,800 | | | | Term C | 43,600 | | | 43,600 | | | | Term D | 43,600 | | | 43,600 | | | | Term E | 32,700 | | | 32,700 | | | | Term F | 32,700 | | | 32,700 | | | | Term G | 32,700 | | | 32,700 | | | | Less: debt discount | (13,518) | | | (15,931) | | | | | | | | | | | | | | | | Long-term debt, including debt discount and final payment fee | $ | 204,482 | | | $ | 202,069 | | | |
As of June 30, 2023, and unless extended in accordance with the terms described above, the Company’s interest-only period will continue through February 2025, with principal payments beginning in March 2025. Future principal payments and final fee payments will be made as follows (in thousands): | | | | | | | | | | | | | AS OF | | | | | | JUNE 30, 2023 | | | 2025 | | | $ | 86,956 | | | | 2026 | | | 104,348 | | | | 2027 | | | 26,696 | | | | Total future minimum payments | | | 218,000 | | | | Less: unamortized debt discount | | | (13,518) | | | | Total debt | | | $ | 204,482 | | | |
The Company’s obligations under the Amended 2020 Loan Agreement are secured by a first priority security interest of substantially all of the Company’s assets with a positive lien on intellectual property. The Amended 2020 Loan Agreement includes customary events of default, including instances of a material adverse change in the Company’s operations, that may require prepayment of the outstanding term loans. Additionally, following the June 2021 Amendment, the Amended 2020 Loan Agreement requires the Company to maintain a minimum cash balance of $20.0 million. As of June 30, 2023, the Company is in compliance with all covenants under the Amended 2020 Loan Agreement and has not received any notification or indication from Oxford of an intent to declare the loan due prior to maturity. Concurrently with the February 2022 Amendment, the Company issued 40,000 warrants to Oxford to purchase shares of the Company’s common stock at an exercise price of $45.00. Upon issuance, the warrants were classified as equity and recorded at their fair value of $0.7 million. See Note 4 for further discussion of these warrants. Interest Expense Interest expense is calculated using the effective interest method and is inclusive of non-cash amortization of the debt discount and accretion of the final payment. During the three months ended June 30, 2023, interest expense was $7.9 million, $1.2 million of which related to non-cash amortization of the debt discount and accretion of the final payment. During the three months ended June 30, 2022, interest expense was $3.2 million, $0.7 million of which related to non-cash amortization of the debt discount and accretion of the final payment. During the six months ended June 30, 2023, interest expense was $15.5 million, $2.4 million of which related to non-cash amortization of the debt discount and accretion of the final payment. During the six months ended June 30, 2022, interest expense was $5.5 million, $1.2 million of which related to non-cash amortization of the debt discount and accretion of the final payment.
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- DefinitionThe entire disclosure for information about short-term and long-term debt arrangements, which includes amounts of borrowings under each line of credit, note payable, commercial paper issue, bonds indenture, debenture issue, own-share lending arrangements and any other contractual agreement to repay funds, and about the underlying arrangements, rationale for a classification as long-term, including repayment terms, interest rates, collateral provided, restrictions on use of assets and activities, whether or not in compliance with debt covenants, and other matters important to users of the financial statements, such as the effects of refinancing and noncompliance with debt covenants.
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v3.23.2
STOCKHOLDERS’ EQUITY
|
6 Months Ended |
Jun. 30, 2023 |
Equity [Abstract] |
|
STOCKHOLDERS’ EQUITY |
STOCKHOLDERS’ EQUITY Common Stock In September 2021, the Company entered into the Open Market Sale Agreement, or the Sales Agreement, with Jefferies LLC, or the Sales Agent, under which it may, from time to time, sell shares of its common stock having an aggregate offering price of up to $200.0 million through the Sales Agent. Pursuant to the Sales Agreement, the Company will pay the Sales Agent a commission for its services in acting as an agent in the sale of common stock in an amount equal to 3% of the gross sales price per share sold. During each of the six months ended June 30, 2023 and June 30, 2022, the Company did not issue any shares under the Sales Agreement. Common Stock Warrants As of June 30, 2023, the following equity-classified warrants were outstanding: | | | | | | | | | | | | | | | Expiration Date | | Shares of Common Stock Issuable Upon Exercise of Warrants | | Exercise Price per Share | July 15, 2030 | | 7,354 | | | $ | 17.00 | | February 18, 2032 | | 40,000 | | $ | 45.00 | |
The Company’s warrants are equity-classified and carried at the instruments’ fair value upon classification into equity, with no subsequent remeasurements.
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- DefinitionThe entire disclosure for equity.
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v3.23.2
EQUITY COMPENSATION PLAN
|
6 Months Ended |
Jun. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
EQUITY COMPENSATION PLAN |
EQUITY COMPENSATION PLAN Stock Incentive Plan The Company’s share-based compensation plan, the Amended and Restated 2017 Employee, Director and Consultant Equity Incentive Plan, or the 2017 Plan, provides for the issuance of incentive stock options, restricted and unrestricted stock awards, and other stock-based awards. As of June 30, 2023, an aggregate of 7.8 million shares of common stock were reserved for issuance under the 2017 Plan, of which 0.5 million were available. Stock Option Activity The Company recognizes compensation costs related to stock-based awards, including stock options, based on the estimated fair value of the awards on the date of grant. The Company grants options with an exercise price equal to the fair market value of the Company’s stock on the date of the option grant. The options are subject to four-year vesting with a one-year cliff and have a contractual term of 10 years. A summary of the Company’s stock option activity under its 2017 Plan for the six months ended June 30, 2023 is as follows (in thousands, except for per share data and years): | | | | | | | | | | | | | | | | | | | | | | | | | Number of Shares | | Weighted Average Exercise Price | | Weighted Average Remaining Contractual Term (In Years) | | Aggregate Intrinsic Value | | | | | | | | | | | | | | | | | | | | | | | | | Outstanding as of December 31, 2022 | 5,305 | | | $ | 22.95 | | | | | | Granted | 1,478 | | | $ | 23.10 | | | | | | Exercised | (103) | | | $ | 11.74 | | | | | | Forfeited | (72) | | | $ | 28.35 | | | | | | Outstanding as of June 30, 2023 | 6,608 | | | $ | 23.10 | | | 8.1 | | $ | 35,768 | | Vested and exercisable as of June 30, 2023 | 2,855 | | | $ | 20.93 | | | 6.9 | | $ | 22,466 | |
The aggregate intrinsic value of stock options exercised during the six months ended June 30, 2023 and June 30, 2022 was $1.3 million and $1.0 million, respectively. Aggregate intrinsic value of stock options exercised and outstanding is calculated using the fair value of common stock on the date of exercise and as of June 30, 2023, respectively. The total fair value of stock options vested during the six months ended June 30, 2023 and June 30, 2022 was $13.8 million and $16.1 million, respectively. The Company expects all outstanding stock options to vest. Stock-Based Compensation Expense The weighted-average assumptions used by the Company to estimate the fair value of stock option grants using the Black-Scholes option pricing model, as well as the resulting weighted-average fair value for the six months ended June 30, 2023 and June 30, 2022 were as follows: | | | | | | | | | | | | | SIX MONTHS ENDED JUNE 30, | | 2023 | | 2022 | | | | | Risk-free interest rate | 3.73 | % | | 2.17 | % | Expected volatility | 84.35 | % | | 85.12 | % | Expected dividend yield | — | % | | — | % | Expected term (in years) | 6.08 | | 6.08 | Weighted average fair value | $ | 16.97 | | | $ | 18.75 | |
Stock-based compensation expense for stock options consisted of the following (in thousands): | | | | | | | | | | | | | | | | | | | | | | | | | THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, | | 2023 | | 2022 | | 2023 | | 2022 | Research and development | $ | 4,245 | | | $ | 3,540 | | | $ | 8,094 | | | $ | 7,219 | | General and administrative | 2,008 | | | 1,756 | | | 3,795 | | | 3,185 | | Total stock-based compensation expense | $ | 6,253 | | | $ | 5,296 | | | $ | 11,889 | | | $ | 10,404 | |
As of June 30, 2023, the Company had $64.4 million of total unrecognized stock-based compensation expense related to its stock options, which is expected to be recognized over a weighted-average period of 2.8 years.
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- DefinitionThe entire disclosure for share-based payment arrangement.
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v3.23.2
LICENSE AND GRANT REVENUES
|
6 Months Ended |
Jun. 30, 2023 |
Collaborative Arrangement and Arrangement Other than Collaborative [Abstract] |
|
LICENSE AND GRANT REVENUES |
LICENSE AND GRANT REVENUES The following table summarizes the total revenue recorded in the Company’s condensed consolidated statements of operations (in thousands): | | | | | | | | | | | | | | | | | | | | | | | | | THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, | | 2023 | | 2022 | | 2023 | | 2022 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | License fee revenue | | | | | | | | Chiesi Farmaceutici S.p.A. | $ | 30 | | | $ | 98 | | | $ | 47 | | | $ | 339 | | Phylaxis BioScience, LLC | — | | | 413 | | | — | | | 1,087 | | 2seventy bio, Inc. | — | | | 200 | | | — | | | 200 | | | | | | | | | | Total license fee revenue | 30 | | | 711 | | | 47 | | | 1,626 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Grant revenue | — | | | — | | | — | | | 14 | | Total revenue | $ | 30 | | | $ | 711 | | | $ | 47 | | | $ | 1,640 | |
License and Collaboration Agreements Chiesi In May 2019, the Company entered into an Option Agreement, as amended by the First Amendment to Option Agreement, dated August 19, 2019, or the Chiesi Option Agreement, with Chiesi Farmaceutici S.p.A., or Chiesi, pursuant to which the Company granted to Chiesi an exclusive option to obtain an exclusive license to develop and commercialize INBRX-101 outside of the United States and Canada. Additionally, the Chiesi Option Agreement provides Chiesi with a right of negotiation for INBRX-101 development and commercialization rights in the United States and Canada in the event that the Company engages in discussions with any third parties for such rights during the term of the Chiesi Option Agreement or, as applicable, the term of a definitive exclusive license agreement between Chiesi and the Company. Under the terms of the Chiesi Option Agreement, the Company received a one-time, non-refundable option initiation payment of $10.0 million in August 2019. If Chiesi chooses to exercise its option under the Chiesi Option Agreement, then Chiesi must pay the Company a one-time, non-refundable fee of $12.5 million upon the effective date of the definitive agreement granting Chiesi the exclusive license. If the option is exercised, under the license agreement, the Company may be entitled to receive specified milestone payments of up to $122.5 million, as well as royalties on future product sales. The Company has identified one performance obligation as of the effective date of the Chiesi Option Agreement, which is to perform research and development services for Chiesi during the option period, which will continue (unless the Chiesi Option Agreement is terminated earlier by Chiesi or the Company) until 60 days following the last to occur of (i) the Company’s delivery to Chiesi of the trial phase data for the first Phase I Clinical Trial, (ii) the Company’s delivery to Chiesi of the finalized minutes from the definitive U.S. Food and Drug Administration, or FDA, scientific advice meeting conducted following completion of such Phase I Clinical Trial, and (iii) the Company’s delivery to Chiesi of written scientific advice from the European Medicines Agency following completion of such Phase I Clinical Trial. The Company has determined that the option to grant a license in the future is not a material right. On July 24, 2023, the Company received written scientific advice from the EMA which confirmed CT lung densitometry as the established primary regulatory endpoint to support a marketing authorization application in the European Union for the treatment of emphysema secondary to AATD. The Company provided a copy of the EMA scientific advice to Chiesi upon receipt which, as described above, fulfilled the necessary deliverables to Chiesi and triggered its 60-day option period window. If Chiesi chooses to exercise its option by September 22, 2023, pursuant to the Chiesi Option Agreement, a one-time, non-refundable option exercise payment of $12.5 million will be payable to the Company. The $10.0 million upfront payment has been allocated to the single performance obligation. Revenue is recognized over time as services are performed during the option period, based on the Company’s effort to satisfy the performance obligation relative to the total expense estimated to be incurred during the option period. During the three months ended June 30, 2023 and June 30, 2022, the Company recognized $17,000 and $0.1 million in revenue related to this agreement, respectively. During the six months ended June 30, 2023 and June 30, 2022, the Company recognized $47,000 and $0.3 million in revenue related to this agreement, respectively. As of June 30, 2023 and December 31, 2022, the Company had $0.1 million of deferred revenue related to this agreement at each date, all of which is classified as current deferred revenue in each period. Phylaxis In July 2020, the Company entered into a joint venture with Phylaxis BioScience, LLC, or Phylaxis. In connection with the joint venture, the Company entered into the following agreements: Contribution Agreement, License Agreement, Limited Liability Company Agreement and Master Services Agreement, or collectively the Phylaxis Agreements, pursuant to which the Company licensed certain intellectual property and know-how to Phylaxis and agreed to provide services to develop certain compounds. Upon closing, the Company received a $2.5 million nonrefundable, upfront payment from Phylaxis under the Master Services Agreement, or the MSA. The Company has also received an additional $2.5 million, which was payable within 180 days from closing under the MSA, in two payments of $1.25 million each, received in October 2020 and January 2021. Upon closing, the Company received a 10% equity interest in Phylaxis as consideration for the contribution of the license of the Company’s intellectual property and know-how and is entitled to receive an additional 5% based on the achievement of certain milestones. Under the License Agreement, the Company is also entitled to specified development and commercialization milestone payments of up to an aggregate of $225.0 million and $175.0 million, respectively. The Company is also entitled to share in a percentage of the profits of Phylaxis under the Limited Liability Company Agreement. In order to determine the fair value of the equity interest in Phylaxis, the Company engaged a third-party valuation specialist. The valuation report utilized a market approach to establish the total equity value of Phylaxis using inputs not observable in the market, including the discount rate. The fair value of the equity interest was $0.5 million, which has been accounted for under the equity method. The fair value of the equity interest upon the execution of the agreements has been included in the transaction price, along with the $5.0 million of payments due pursuant to the MSA. The Company identified the transfer of the exclusive licenses for, and performance of, development services to modify the first and second compounds as one performance obligation and allocated the transaction price evenly between the two compounds. Revenue related to the performance obligation will be recognized over time as services are performed, based on the Company’s progress to satisfy the performance obligation. During the third quarter of 2022, the Company fulfilled this performance obligation in full and recognized all remaining deferred revenue under this contract. During the three and six months ended June 30, 2023, the Company recognized no revenue related to this performance obligation following its completion in 2022. During the three months ended June 30, 2022, the Company recognized $0.4 million of revenue related to this performance obligation. During the six months ended June 30, 2022, the Company recognized $1.1 million of revenue related to this performance obligation. As of June 30, 2023 and December 31, 2022, there was no deferred revenue remaining related to the Phylaxis Agreements. 2seventy In June 2020, the Company entered into an Option and License Agreement with bluebird bio, Inc., or bluebird, pursuant to which the Company granted to bluebird exclusive worldwide rights to develop binders and cell therapy products containing single domain antibodies, or sdAbs, directed to specified targets, consisting of two initial programs and up to an additional 8 programs. The Company retains all rights to the specific sdAbs outside of the cell therapy field. In November 2021, this agreement, or the 2020 2seventy Agreement, was also assigned to 2seventy bio, Inc., or 2seventy, in connection with bluebird’s internal restructuring and subsequent spin-out of 2seventy. In June 2020, the Company received a non-refundable upfront option fee of $0.2 million in connection with each of the two initial programs, or $0.4 million in aggregate, and is entitled to an upfront option fee for each additional program, on a program-by-program basis. In June 2022, 2seventy selected a third program and paid a non-refundable upfront option fee of $0.2 million in exchange for a development license. Under each of the three programs, the Company granted an option in which 2seventy may acquire an exclusive license with respect to all binders and cell therapy products developed under this agreement, which entitles the Company to additional fees upon exercise of the option. In connection with each program for which 2seventy exercises its option, 2seventy will be required to pay the Company a one-time, non-refundable, non-creditable fee in the low-single-digit millions. The Company is also entitled to receive certain developmental milestone payments of up to an aggregate of $51.5 million per therapeutic, as well as percentage tiered royalties on future product sales with rates in the mid-single-digits. Due to the uncertainty in the achievement of the developmental milestones and future sales, the variable consideration associated with the future milestone payments has been fully constrained (excluded) from the transaction price until such time that the Company concludes that it is probable that a significant reversal of previously recognized revenue will not occur. These estimates will be re-assessed at each reporting period. As of the effective date of the 2020 2seventy Agreement, the Company identified one performance obligation, which was the transfer of the exclusive development license to bluebird for the two initial programs. The Company determined that the option granted for an exclusive license in the future was not a material right. For the eight programs not identified upon execution of the contract, the Company evaluated the customer option for additional purchases and determined that those options for additional programs did not constitute material rights nor variable consideration. As additional programs are identified, the Company re-assesses its performance obligations and transaction price accordingly. In June 2022, pursuant to the terms regarding the addition of new programs in the 2020 2seventy Agreement, the Company received a $0.2 million upfront option fee related to the selection of a third program and transferred the related know-how and development license. The Company recognized the $0.2 million of revenue at the point in time in which the program was added and the program term began. During the three and six months ended June 30, 2022, the Company recognized $0.2 million of revenue related to this agreement. During the three and six months ended June 30, 2023, the Company did not recognize any revenue related to this agreement.
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v3.23.2
COMMITMENTS AND CONTINGENCIES
|
6 Months Ended |
Jun. 30, 2023 |
Commitments and Contingencies Disclosure [Abstract] |
|
COMMITMENTS AND CONTINGENCIES |
COMMITMENTS AND CONTINGENCIES Operating Leases In September 2017, the Company entered into a seven-year lease agreement as its sole location in La Jolla, California. The lease expires in June 2025 with an option to extend the lease an additional five years. The lease contained an initial base rent of approximately $0.1 million per month with 2% annual escalations, plus a percentage of taxes and operating expenses incurred by the lessor in connection with the ownership and management of the property, the latter of which to be determined annually. In May 2019, the Company executed an amendment to its lease agreement to expand its facilities and began occupying this space in January 2020. The amended lease terminates coterminously with the initial lease agreement and contains an initial base rent of approximately $30,000 per month with 2% annual escalations, plus a percentage of taxes and operating expenses incurred by the lessor in connection with the ownership and management of the property, the latter of which is to be determined annually. The right-of-use asset and operating lease liability as of June 30, 2023 and December 31, 2022 are as follows (in thousands): | | | | | | | | | | | | | AS OF | | AS OF | | JUNE 30, 2023 | | DECEMBER 31, 2022 | | | | | Right-of-use asset | $ | 3,853 | | | $ | 4,717 | | | | | | Operating lease liability | | | | Current | $ | 1,959 | | | $ | 1,860 | | Non-current | 2,171 | | | $ | 3,173 | | Total operating lease liability | $ | 4,130 | | | $ | 5,033 | |
During each of the three months ended June 30, 2023 and June 30, 2022, the Company recognized operating lease expense of $0.8 million. During the six months ended June 30, 2023 and June 30, 2022, the Company recognized operating lease expense of $1.7 million and $1.6 million, respectively. During each of the three months ended June 30, 2023 and June 30, 2022, the Company paid $0.5 million in cash for amounts included in the measurement of the operating lease liability. During each of the six months ended June 30, 2023 and June 30, 2022, the Company paid $1.1 million in cash for amounts included in the measurement of the operating lease liability. As of June 30, 2023 and December 31, 2022, the Company’s operating lease had a remaining term of 2.0 and 2.5 years, respectively. The Company discounts its lease payments using its incremental borrowing rate as of the commencement of the lease. The Company has determined a weighted-average discount rate of 8.2% as of June 30, 2023 and December 31, 2022. Future minimum rental commitments for the Company’s operating leases reconciled to the lease liability are as follows (in thousands): | | | | | | | | | AS OF | | | | JUNE 30, 2023 | | | | | | | 2023 | $ | 1,110 | | | | 2024 | 2,247 | | | | 2025 | 1,137 | | | | Thereafter | — | | | | Total future minimum lease payments | $ | 4,494 | | | | Less: imputed interest | (364) | | | | Present value of operating lease liability | 4,130 | | | | Less: current portion of operating lease liability | (1,959) | | | | Non-current portion of operating lease liability | $ | 2,171 | | | |
Purchase Commitments The Company has several ongoing contracts with CROs for preclinical studies and clinical trials and with CDMOs for clinical supplies and manufacturing scale-up activities. While these contracts are generally cancellable, some may contain specific activities that involve one or more non-cancellable commitments, including minimum purchase commitments, binding annual forecasts and capital equipment investments. Additionally, depending on the timing and reasoning of the exit, certain termination penalties may apply and can range from cost of work performed to date and up to twelve months of future committed manufacturing costs. As of June 30, 2023 and December 31, 2022, the non-cancellable portion of these contracts total in aggregate, excluding amounts paid or incurred at each respective date, approximately $76.5 million and $74.8 million, respectively. The non-cancellable purchase commitments relate to the purchase of raw materials and future contract manufacturing of drug supply for INBRX-101. During the six months ended June 30, 2023 and June 30, 2022, the Company incurred $1.0 million and $0.6 million, respectively, of expenses related to its non-cancellable purchase agreements. Litigation The Company is not party to any material legal proceedings. From time to time, it may be involved in legal proceedings or subject to claims incident to the ordinary course of business. Regardless of the outcome, such proceedings or claims can have an adverse impact on the Company because of defense and settlement costs, diversion of resources and other factors, and there can be no assurances that favorable outcomes will be obtained.
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v3.23.2
ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)
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6 Months Ended |
Jun. 30, 2023 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
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Basis of Presentation |
Basis of Presentation The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America, or GAAP, and applicable rules and regulations of the Securities and Exchange Commission, or the SEC, related to an interim report on the Form 10-Q. The unaudited condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiary. All intercompany accounts and transactions have been eliminated in consolidation. The unaudited interim condensed consolidated financial statements reflect all adjustments which, in the opinion of management, are necessary for a fair statement of the results for the periods presented. All such adjustments are of a normal and recurring nature. The operating results presented in these unaudited interim condensed consolidated financial statements are not necessarily indicative of the results that may be expected for any future periods. Certain information and note disclosures normally included in annual financial statements prepared in accordance with GAAP have been condensed or omitted. Accordingly, the accompanying unaudited interim condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the related notes thereto for the fiscal year ended December 31, 2022, which are included in the Company’s Annual Report on Form 10-K filed with the SEC on March 6, 2023.
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Liquidity |
Liquidity As of June 30, 2023, the Company had an accumulated deficit of $468.3 million and cash and cash equivalents of $192.5 million. From its inception and through June 30, 2023, the Company has devoted substantially all of its efforts to therapeutic drug discovery and development, conducting preclinical studies and clinical trials, enabling manufacturing activities in support of its therapeutic candidates, pre-commercialization activities, organizing and staffing the Company, establishing its intellectual property portfolio and raising capital to support and expand these activities. The Company believes that its existing cash and cash equivalents will be sufficient to fund the Company’s operations for at least 12 months from the date these condensed consolidated financial statements are issued. The Company plans to finance its future cash needs through equity offerings, debt financings or other capital sources, including potential collaborations, licenses, strategic transactions and other similar arrangements. If the Company does raise additional capital through public or private equity or convertible debt offerings, the ownership interests of its existing stockholders will be diluted, and the terms of those securities may include liquidation or other preferences that adversely affect its stockholders’ rights. If the Company raises capital through additional debt financings, it may be subject to covenants limiting or restricting its ability to take specific actions, such as incurring additional debt or making certain capital expenditures. To the extent that the Company raises additional capital through strategic licensing, collaboration or other similar agreement, it may have to relinquish valuable rights to its therapeutic candidates, future revenue streams or research programs at an earlier stage of development or on less favorable terms than it would otherwise choose, or to grant licenses on terms that may not be favorable to the Company. There can be no assurance as to the availability or terms upon which such financing and capital might be available in the future. If the Company is unable to secure adequate additional funding, it will need to reevaluate its operating plan and may be forced to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible, delay, scale back or eliminate some or all of its development programs, or relinquish rights to its technology on less favorable terms than it would otherwise choose. These actions could materially impact its business, financial condition, results of operations and prospects. The rules and regulations of the SEC or any other regulatory agencies may restrict the Company’s ability to conduct certain types of financing activities, or may affect the timing of and amounts it can raise by undertaking such activities.
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Use of Estimates |
Use of Estimates The preparation of these unaudited condensed consolidated financial statements in conformity with GAAP requires the Company to make estimates and judgments that affect the reported amounts of assets, liabilities, revenue and expense and the disclosure of contingent assets and liabilities in the Company’s financial statements and accompanying notes. The Company’s most significant estimates relate to evaluation of whether revenue recognition criteria have been met, accounting for development work and preclinical studies and clinical trials, determining the assumptions used in measuring stock-based compensation, the incremental borrowing rate estimated in relation to the Company’s operating lease, and valuation allowances for the Company’s deferred tax assets. The Company bases its estimates on historical experience, known trends and other market-specific or other relevant factors that it believes to be reasonable under the circumstances. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. The Company’s actual results may differ from these estimates under different assumptions or conditions.
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Cash and Cash Equivalents |
Cash and Cash EquivalentsCash and cash equivalents are comprised of cash held in financial institutions including readily available checking and money market accounts and highly liquid investments in debt securities with an original maturity of three months or less.
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Concentrations of Credit Risk |
Concentrations of Credit Risk Financial instruments that subject the Company to significant concentrations of credit risk consist primarily of cash and cash equivalents, including investments in debt securities. The Company maintains deposits in federally insured financial institutions in excess of federally insured limits by the Federal Deposit Insurance Corporation, or FDIC, of up to $250,000. The Company’s investment portfolio consists of investments in U.S. Treasury securities, in excess of Securities Investor Protection Corporation limits of up to $500,000 in securities. The Company’s cash management and investment policy limits investment instruments to investment-grade securities with the objective to preserve capital and to maintain liquidity until the funds can be used in operations. The Company has not experienced any losses in such accounts and believes it is not exposed to significant risk on its cash balances due to the financial condition of the depository institutions in which those deposits are held.
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Fair Value Measurements |
Fair Value Measurements The Company determines the fair value measurements of applicable assets and liabilities based on a three-tier fair value hierarchy established by accounting guidance and prioritizes the inputs used in measuring fair value. These tiers include: •Level 1 - Quoted prices in active markets for identical assets or liabilities. •Level 2 - Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. •Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. In certain cases, the inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, the level in the fair value hierarchy within which the fair value measurement in its entirety falls has been determined based on the lowest level input that is significant to the fair value measurement in its entirety. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires judgment and considers factors specific to the asset or liability. The Company’s investments in debt securities consist of U.S. Treasury Bills, which are classified as Level 1 in the fair value hierarchy. Due to the short-term nature of these securities which are classified as cash equivalents, the amortized value approximates fair value and the Company does not remeasure these instruments at fair value. The Company’s outstanding debt and warrants are both classified as Level 2 in the fair value hierarchy.
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Revenue Recognition |
Revenue Recognition The Company has generated revenue from its license and collaboration agreements with partners, as well as from grants from government agencies and private not-for-profit organizations. Collaborative Research, Development, and License Agreements The Company enters into collaborative agreements with partners which may include the transfer of licenses, options to license and the performance of research and development activities. The terms associated with these agreements may include one or more of the following: (1) license fees; (2) nonrefundable up-front fees; (3) payments for reimbursement of research costs; (4) payments associated with achieving specific development, regulatory or commercial milestones; and (5) royalties based on specified percentages of net product sales, if any. Payments received from customers are included in deferred revenue, allocated between current and non-current on the condensed consolidated balance sheet, until all revenue recognition criteria are met. Typically, license fees, non-refundable upfront fees and funding of research activities are considered fixed, while milestone payments, including option exercise fees, are identified as variable consideration, which is constrained and excluded from the transaction price. The Company will recognize revenue for sales-based royalty if and when a subsequent sale occurs. The Company applies significant judgment when making estimates and assumptions under these agreements, including evaluating whether contractual obligations represent distinct performance obligations, including the assessment of whether options represent material rights, determining whether there are observable standalone prices and allocating transaction price to performance obligations within a contract, assessing whether any licenses are functional or symbolic, determining when performance obligations have been met, and assessing the recognition of variable consideration. The Company evaluates each performance obligation to determine if it can be satisfied and recognized as revenue at a point in time or over time. Typically, performance obligations consisting of a transfer of a license or the achievement of milestones are recognized at a point in time upon the transfer, while performance obligations consisting of research activities are recognized over time using an input method which is representative of the Company’s efforts to fulfill the performance obligation, based on costs incurred with third-parties or internal labor hours performed.
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Accrued Research and Development and Clinical Trial Costs |
Accrued Research and Development and Clinical Trial Costs Research and development costs are expensed as incurred and include the cost of compensation and related expenses, as well as expenses for third parties who conduct research and development on the Company’s behalf, pursuant to development and consulting agreements in place. The Company’s preclinical studies and clinical trials are performed internally, by third party contract research organizations, or CROs, and/or clinical investigators. The Company also engages with contract development and manufacturing organizations, or CDMOs, for clinical supplies and manufacturing scale-up activities related to its therapeutic candidates. Invoicing from these third parties may be monthly based upon services performed or based upon milestones achieved. The Company accrues these expenses based upon its assessment of the status of each clinical trial and the work completed, and upon information obtained from the CROs and CDMOs. The Company’s estimates are dependent upon the timeliness and accuracy of data provided by the CROs and CDMOs regarding the status and cost of the studies. Costs incurred related to the Company’s purchases of in-process research and development for early-stage products or products that are not commercially viable and ready for use, or have no alternative future use, are charged to expense in the period incurred. Costs incurred related to the licensing of products that have not yet received marketing approval to be marketed, or that are not commercially viable and ready for use, or have no alternative future use, are charged to expense in the period incurred.
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Income Taxes |
Income Taxes Income taxes are accounted for under the asset and liability method. Deferred income taxes are recorded for temporary differences between financial statement carrying amounts and the tax basis of assets and liabilities. Deferred tax assets and liabilities reflect the tax rates expected to be in effect for the years in which the differences are expected to reverse. A valuation allowance is provided if it is more likely than not that some or all of the deferred tax assets will not be realized.
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Net Loss Per Share |
Net Loss Per Share Basic net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding during the same period. Diluted net loss per share is computed by dividing net loss by the weighted average number of common and common equivalent shares outstanding during the same period. The Company excludes common stock equivalents from the calculation of diluted net loss per share when the effect is anti-dilutive. For purposes of the diluted net loss per share calculation, warrants for purchase of common stock and stock options are considered to be potentially dilutive securities. Accordingly, for the six months ended June 30, 2023 and June 30, 2022, there is no difference in the number of shares used to calculate basic and diluted shares outstanding.
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Segment Information |
Segment Information The Company operates under one segment which develops biologic therapeutic candidates. Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker in making decisions regarding resource allocation and assessing performance.
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Recent Accounting Pronouncements |
Recent Accounting Pronouncements From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board, or FASB, or other standard setting bodies. The Company believes that the impact of the recently issued accounting pronouncements that are not yet effective will not have a material impact on its condensed consolidated financial condition or results of operations upon adoption. Adoption of New Accounting Pronouncements In June 2016, the FASB issued Accounting Standards Update, or ASU, 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (Topic 326), which intends to improve financial reporting by requiring earlier recognition of credit losses on certain financial assets, such as held-to-maturity debt securities. Subsequent to the issuance of ASU 2016-13, the FASB issued several additional ASUs to clarify implementation guidance, provide narrow-scope improvements and provide additional disclosure guidance. The Company adopted ASU 2016-13 as of January 1, 2023, which did not result in a material impact on its condensed consolidated financial statements and related disclosures.
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v3.23.2
OTHER FINANCIAL INFORMATION (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Schedule of Prepaid Expense and Other Current Assets |
Prepaid expense and other current assets were comprised of the following (in thousands): | | | | | | | | | | | | | AS OF | | AS OF | | JUNE 30, 2023 | | DECEMBER 31, 2022 | Clinical trials (1) | $ | 6,835 | | | $ | 4,294 | | Clinical drug substance and product manufacturing (2) | 2,362 | | | 1,171 | | Outside research and development services (3) | 280 | | | 232 | | | | | | Licenses | 701 | | | 493 | | Other | 324 | | | 181 | | Prepaid expense and other current assets | $ | 10,502 | | | $ | 6,371 | |
(1) Relates primarily to the Company’s prepayments to third-party CROs for management of clinical trials and prepayments for drug supply to be used in combination with the Company’s therapeutics. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development. (2) Relates primarily to the Company’s usage of third-party CDMOs for clinical and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development. (3) Relates to the Company’s usage of third-parties for other research and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development.
|
Schedule of Property and Equipment |
Property and equipment, net were comprised of the following (in thousands): | | | | | | | | | | | | | AS OF | | AS OF | | JUNE 30, 2023 | | DECEMBER 31, 2022 | | | | | Machinery and equipment | $ | 7,393 | | | $ | 7,023 | | Leasehold improvements | 441 | | | 441 | | Computer software | 53 | | | 53 | | Furniture, fixtures, and other | 527 | | | 524 | | Construction in process | 518 | | | — | | Total property and equipment | 8,932 | | | 8,041 | | Less: accumulated depreciation and amortization | (6,100) | | | (5,540) | | Property and equipment, net | $ | 2,832 | | | $ | 2,501 | |
Depreciation and amortization expense totaled $0.3 million for each of the three months ended June 30, 2023 and June 30, 2022, and $0.6 million for each of the six months ended June 30, 2023 and June 30, 2022 and consisted of the following (in thousands): | | | | | | | | | | | | | | | | | | | | | | | | | THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, | | 2023 | | 2022 | | 2023 | | 2022 | Research and development | $ | 242 | | | $ | 248 | | | $ | 479 | | | $ | 506 | | General and administrative | 53 | | | 59 | | | 110 | | | 108 | | Total depreciation and amortization expense | $ | 295 | | | $ | 307 | | | $ | 589 | | | $ | 614 | |
|
Schedule of Accrued Expenses |
Accrued expenses were comprised of the following (in thousands): | | | | | | | | | | | | | AS OF | | AS OF | | JUNE 30, 2023 | | DECEMBER 31, 2022 | | | | | Clinical trials(1) | $ | 8,185 | | | $ | 4,527 | | Clinical drug substance and product manufacturing(2) | 3,335 | | | 5,381 | | Other outside research and development (3) | 1,397 | | | 1,164 | | Interest expense | 2,230 | | | 2,124 | | Compensation-related | 3,390 | | | 3,374 | | Professional fees | 674 | | | 428 | | | | | | Other | 340 | | | 226 | | Accrued expenses | $ | 19,551 | | | $ | 17,224 | |
(1) Relates primarily to the Company’s usage of third-party CROs for management of clinical trials. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development. (2) Relates primarily to the Company’s usage of third-party CDMOs for clinical and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development. (3) Relates to the Company’s usage of third-parties for other research and development efforts. See “Accrued Research and Development Clinical Trial Costs” in Note 1 for further discussion of the components of research and development.
|
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v3.23.2
DEBT (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Debt Disclosure [Abstract] |
|
Schedule of Long-term Debt |
The Company’s outstanding debt balance under the Amended 2020 Loan Agreement consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands). | | | | | | | | | | | | | | | AS OF | | AS OF | | | | JUNE 30, 2023 | | DECEMBER 31, 2022 | | | Term A | $ | 10,900 | | | $ | 10,900 | | | | Term B | 21,800 | | | 21,800 | | | | Term C | 43,600 | | | 43,600 | | | | Term D | 43,600 | | | 43,600 | | | | Term E | 32,700 | | | 32,700 | | | | Term F | 32,700 | | | 32,700 | | | | Term G | 32,700 | | | 32,700 | | | | Less: debt discount | (13,518) | | | (15,931) | | | | | | | | | | | | | | | | Long-term debt, including debt discount and final payment fee | $ | 204,482 | | | $ | 202,069 | | | |
|
Schedule of Maturities of Long-term Debt |
Future principal payments and final fee payments will be made as follows (in thousands): | | | | | | | | | | | | | AS OF | | | | | | JUNE 30, 2023 | | | 2025 | | | $ | 86,956 | | | | 2026 | | | 104,348 | | | | 2027 | | | 26,696 | | | | Total future minimum payments | | | 218,000 | | | | Less: unamortized debt discount | | | (13,518) | | | | Total debt | | | $ | 204,482 | | | |
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v3.23.2
STOCKHOLDERS’ EQUITY (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Equity [Abstract] |
|
Schedule of Equity-classified Warrants |
As of June 30, 2023, the following equity-classified warrants were outstanding: | | | | | | | | | | | | | | | Expiration Date | | Shares of Common Stock Issuable Upon Exercise of Warrants | | Exercise Price per Share | July 15, 2030 | | 7,354 | | | $ | 17.00 | | February 18, 2032 | | 40,000 | | $ | 45.00 | |
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- DefinitionTabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable.
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v3.23.2
EQUITY COMPENSATION PLAN (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Schedule of Stock Options Roll Forward |
A summary of the Company’s stock option activity under its 2017 Plan for the six months ended June 30, 2023 is as follows (in thousands, except for per share data and years): | | | | | | | | | | | | | | | | | | | | | | | | | Number of Shares | | Weighted Average Exercise Price | | Weighted Average Remaining Contractual Term (In Years) | | Aggregate Intrinsic Value | | | | | | | | | | | | | | | | | | | | | | | | | Outstanding as of December 31, 2022 | 5,305 | | | $ | 22.95 | | | | | | Granted | 1,478 | | | $ | 23.10 | | | | | | Exercised | (103) | | | $ | 11.74 | | | | | | Forfeited | (72) | | | $ | 28.35 | | | | | | Outstanding as of June 30, 2023 | 6,608 | | | $ | 23.10 | | | 8.1 | | $ | 35,768 | | Vested and exercisable as of June 30, 2023 | 2,855 | | | $ | 20.93 | | | 6.9 | | $ | 22,466 | |
|
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions |
The weighted-average assumptions used by the Company to estimate the fair value of stock option grants using the Black-Scholes option pricing model, as well as the resulting weighted-average fair value for the six months ended June 30, 2023 and June 30, 2022 were as follows: | | | | | | | | | | | | | SIX MONTHS ENDED JUNE 30, | | 2023 | | 2022 | | | | | Risk-free interest rate | 3.73 | % | | 2.17 | % | Expected volatility | 84.35 | % | | 85.12 | % | Expected dividend yield | — | % | | — | % | Expected term (in years) | 6.08 | | 6.08 | Weighted average fair value | $ | 16.97 | | | $ | 18.75 | |
|
Schedule of Stock-Based Compensation Expense |
Stock-based compensation expense for stock options consisted of the following (in thousands): | | | | | | | | | | | | | | | | | | | | | | | | | THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, | | 2023 | | 2022 | | 2023 | | 2022 | Research and development | $ | 4,245 | | | $ | 3,540 | | | $ | 8,094 | | | $ | 7,219 | | General and administrative | 2,008 | | | 1,756 | | | 3,795 | | | 3,185 | | Total stock-based compensation expense | $ | 6,253 | | | $ | 5,296 | | | $ | 11,889 | | | $ | 10,404 | |
|
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v3.23.2
LICENSE AND GRANT REVENUES (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Collaborative Arrangement and Arrangement Other than Collaborative [Abstract] |
|
Schedule of License and Grant Revenue |
The following table summarizes the total revenue recorded in the Company’s condensed consolidated statements of operations (in thousands): | | | | | | | | | | | | | | | | | | | | | | | | | THREE MONTHS ENDED JUNE 30, | | SIX MONTHS ENDED JUNE 30, | | 2023 | | 2022 | | 2023 | | 2022 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | License fee revenue | | | | | | | | Chiesi Farmaceutici S.p.A. | $ | 30 | | | $ | 98 | | | $ | 47 | | | $ | 339 | | Phylaxis BioScience, LLC | — | | | 413 | | | — | | | 1,087 | | 2seventy bio, Inc. | — | | | 200 | | | — | | | 200 | | | | | | | | | | Total license fee revenue | 30 | | | 711 | | | 47 | | | 1,626 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Grant revenue | — | | | — | | | — | | | 14 | | Total revenue | $ | 30 | | | $ | 711 | | | $ | 47 | | | $ | 1,640 | |
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v3.23.2
COMMITMENTS AND CONTINGENCIES (Tables)
|
6 Months Ended |
Jun. 30, 2023 |
Commitments and Contingencies Disclosure [Abstract] |
|
Schedule of Operating Lease, by Balance Sheet Location |
The right-of-use asset and operating lease liability as of June 30, 2023 and December 31, 2022 are as follows (in thousands): | | | | | | | | | | | | | AS OF | | AS OF | | JUNE 30, 2023 | | DECEMBER 31, 2022 | | | | | Right-of-use asset | $ | 3,853 | | | $ | 4,717 | | | | | | Operating lease liability | | | | Current | $ | 1,959 | | | $ | 1,860 | | Non-current | 2,171 | | | $ | 3,173 | | Total operating lease liability | $ | 4,130 | | | $ | 5,033 | |
|
Schedule of Operating Lease Maturity |
Future minimum rental commitments for the Company’s operating leases reconciled to the lease liability are as follows (in thousands): | | | | | | | | | AS OF | | | | JUNE 30, 2023 | | | | | | | 2023 | $ | 1,110 | | | | 2024 | 2,247 | | | | 2025 | 1,137 | | | | Thereafter | — | | | | Total future minimum lease payments | $ | 4,494 | | | | Less: imputed interest | (364) | | | | Present value of operating lease liability | 4,130 | | | | Less: current portion of operating lease liability | (1,959) | | | | Non-current portion of operating lease liability | $ | 2,171 | | | |
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- DefinitionAmortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).
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v3.23.2
OTHER FINANCIAL INFORMATION - Property and Equipment (Details) - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
|
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Dec. 31, 2022 |
Property, Plant and Equipment [Line Items] |
|
|
|
|
|
Total property and equipment |
$ 8,932
|
|
$ 8,932
|
|
$ 8,041
|
Less: accumulated depreciation and amortization |
(6,100)
|
|
(6,100)
|
|
(5,540)
|
Property and equipment, net |
2,832
|
|
2,832
|
|
2,501
|
Depreciation and amortization |
295
|
$ 307
|
589
|
$ 614
|
|
Machinery and equipment |
|
|
|
|
|
Property, Plant and Equipment [Line Items] |
|
|
|
|
|
Total property and equipment |
7,393
|
|
7,393
|
|
7,023
|
Leasehold improvements |
|
|
|
|
|
Property, Plant and Equipment [Line Items] |
|
|
|
|
|
Total property and equipment |
441
|
|
441
|
|
441
|
Computer software |
|
|
|
|
|
Property, Plant and Equipment [Line Items] |
|
|
|
|
|
Total property and equipment |
53
|
|
53
|
|
53
|
Furniture, fixtures, and other |
|
|
|
|
|
Property, Plant and Equipment [Line Items] |
|
|
|
|
|
Total property and equipment |
527
|
|
527
|
|
524
|
Construction in process |
|
|
|
|
|
Property, Plant and Equipment [Line Items] |
|
|
|
|
|
Total property and equipment |
$ 518
|
|
$ 518
|
|
$ 0
|
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OTHER FINANCIAL INFORMATION - Accrued Expenses (Details) - USD ($) $ in Thousands |
Jun. 30, 2023 |
Dec. 31, 2022 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
|
Clinical trials |
$ 8,185
|
$ 4,527
|
Clinical drug substance and product manufacturing |
3,335
|
5,381
|
Other outside research and development |
1,397
|
1,164
|
Interest expense |
2,230
|
2,124
|
Compensation-related |
3,390
|
3,374
|
Professional fees |
674
|
428
|
Other |
340
|
226
|
Accrued expenses |
$ 19,551
|
$ 17,224
|
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v3.23.2
DEBT - Narrative (Details) $ / shares in Units, shares in Thousands, $ in Thousands |
1 Months Ended |
3 Months Ended |
6 Months Ended |
Oct. 31, 2022
USD ($)
|
Jun. 30, 2022
USD ($)
|
Feb. 28, 2022
USD ($)
tranche
$ / shares
shares
|
Jun. 30, 2021
USD ($)
|
Nov. 30, 2020
USD ($)
|
Jul. 31, 2020
USD ($)
|
Jun. 30, 2023
USD ($)
|
Jun. 30, 2022
USD ($)
|
Mar. 31, 2022
USD ($)
|
Jun. 30, 2023
USD ($)
|
Jun. 30, 2022
USD ($)
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Proceeds from the issuance of debt |
|
|
|
|
|
|
|
|
|
$ 0
|
$ 98,871
|
Reclassification of warrant liabilities to equity |
|
|
|
|
|
|
|
|
$ 712
|
|
|
Amortization of debt discount and accretion |
|
|
|
|
|
|
|
|
|
2,400
|
1,200
|
Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Debt interest expense |
|
|
|
|
|
|
$ 7,900
|
$ 3,200
|
|
15,500
|
$ 5,500
|
Amortization of debt discount and accretion |
|
|
|
|
|
|
1,200
|
$ 700
|
|
|
|
Amended 2020 Oxford Term Loan Tranche One | Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Proceeds from the issuance of debt |
|
|
|
|
|
$ 10,000
|
|
|
|
|
|
Amended 2020 Oxford Term Loan Tranche Two | Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Proceeds from the issuance of debt |
|
|
|
|
$ 20,000
|
|
|
|
|
|
|
Amended 2020 Oxford Term Loan June 2021 Amendment | Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Proceeds from the issuance of debt |
|
|
|
$ 40,000
|
|
|
|
|
|
|
|
2022 Loan Agreement | Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Proceeds from the issuance of debt |
|
|
$ 40,000
|
|
|
|
|
|
|
|
|
Number of additional tranches available upon contingent events | tranche |
|
|
3
|
|
|
|
|
|
|
|
|
Minimum cash balance |
|
|
|
|
|
|
20,000
|
|
|
20,000
|
|
2022 Loan Agreement | Secured Debt | Warrants Issued Concurrently With 2022 Loan Agreement |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Warrants issued (in shares) | shares |
|
|
40
|
|
|
|
|
|
|
|
|
Warrant price (in dollars per share) | $ / shares |
|
|
$ 45.00
|
|
|
|
|
|
|
|
|
Reclassification of warrant liabilities to equity |
|
|
$ 700
|
|
|
|
|
|
|
|
|
Amended 2020 Oxford Term Loan February 2022 Amendment Tranche One | Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Proceeds from the issuance of debt |
|
$ 30,000
|
|
|
|
|
|
|
|
|
|
Amended 2020 Oxford Term Loan February 2022 Amendment Tranche Two | Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Proceeds from the issuance of debt |
|
$ 30,000
|
|
|
|
|
|
|
|
|
|
Amended 2020 Oxford Term Loan February 2022 Amendment Tranche Three | Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Term loan aggregate amount |
$ 30,000
|
|
|
|
|
|
|
|
|
|
|
Amended 2020 Oxford Term Loan October 2022 Amendment | Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Proceeds from the issuance of debt |
$ 30,000
|
|
|
|
|
|
|
|
|
|
|
Amended 2020 Oxford Term Loan | Secured Debt |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Gross principal outstanding |
|
|
|
|
|
|
$ 200,000
|
|
|
$ 200,000
|
|
Annual interest rate |
|
|
|
|
|
|
8.30%
|
|
|
8.30%
|
|
Equal payments of principal and interest period if interest only period is extended |
|
|
|
|
|
|
|
|
|
23 months
|
|
Upfront licensing or partnership proceeds raised |
|
|
|
|
|
|
|
|
|
$ 100,000
|
|
Equal payments of principal period if interest only period is extended |
|
|
|
|
|
|
|
|
|
11 months
|
|
Percentage of principal amount for final payment |
|
|
|
|
|
|
9.00%
|
|
|
9.00%
|
|
Periodic payment terms, final payment amount |
|
|
|
|
|
|
$ 18,000
|
|
|
$ 18,000
|
|
Amended 2020 Oxford Term Loan | Secured Debt | LIBOR |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Basis spread on variable rate |
|
|
|
|
|
|
|
|
|
8.19%
|
|
2020 Loan Agreement | Secured Debt | Minimum |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Prepayment fee |
|
|
|
|
|
|
1.00%
|
|
|
1.00%
|
|
2020 Loan Agreement | Secured Debt | Maximum |
|
|
|
|
|
|
|
|
|
|
|
Debt Instrument [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
Prepayment fee |
|
|
|
|
|
|
3.00%
|
|
|
3.00%
|
|
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v3.23.2
DEBT - Loan Agreement Balance (Details) - Secured Debt - USD ($) $ in Thousands |
Jun. 30, 2023 |
Dec. 31, 2022 |
2022 Loan A |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
$ 10,900
|
|
2020 Term A |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
|
$ 10,900
|
2022 Loan B |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
21,800
|
|
2020 Term B |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
|
21,800
|
2022 Loan C |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
43,600
|
|
2020 Term C |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
|
43,600
|
2022 Loan D |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
43,600
|
|
2020 Term D |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
|
43,600
|
2022 Term Loan E |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
32,700
|
|
2020 Term Loan E |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
|
32,700
|
2022 Term Loan F |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
32,700
|
|
2020 Term Loan F |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
|
32,700
|
2022 Term Loan G |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
32,700
|
|
2020 Term Loan G |
|
|
Debt Instrument [Line Items] |
|
|
Debt |
|
32,700
|
2022 Loan Agreement |
|
|
Debt Instrument [Line Items] |
|
|
Less: debt discount |
(13,518)
|
|
Total debt |
$ 204,482
|
|
2020 Loan Agreement |
|
|
Debt Instrument [Line Items] |
|
|
Less: debt discount |
|
(15,931)
|
Total debt |
|
$ 202,069
|
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v3.23.2
EQUITY COMPENSATION PLAN - Stock Option Activity (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands |
6 Months Ended |
Jun. 30, 2023 |
Number of Shares |
|
Outstanding, beginning balance (in shares) |
5,305
|
Granted (in shares) |
1,478
|
Exercised (in shares) |
(103)
|
Forfeited (in shares) |
(72)
|
Outstanding, ending balance (in shares) |
6,608
|
Vested and exercisable (in shares) |
2,855
|
Weighted Average Exercise Price |
|
Outstanding, beginning balance (in dollars per share) |
$ 22.95
|
Granted (in dollars per share) |
23.10
|
Exercised (in dollars per share) |
11.74
|
Forfeited (in dollars per share) |
28.35
|
Outstanding, ending balance (in dollars per share) |
23.10
|
Vested and exercisable (in dollars per share) |
$ 20.93
|
Weighted Average Remaining Contractual Term (in years) |
8 years 1 month 6 days
|
Weighted Average Remaining Contractual Term, vested and exercisable |
6 years 10 months 24 days
|
Aggregate Intrinsic Value |
$ 35,768
|
Aggregate Intrinsic Value, vested and exercisable |
$ 22,466
|
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EQUITY COMPENSATION PLAN - Stock-based Compensation Expense (Details) - Employee Stock Option - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
|
|
|
|
Total stock-based compensation expense |
$ 6,253
|
$ 5,296
|
$ 11,889
|
$ 10,404
|
Research and development |
|
|
|
|
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
|
|
|
|
Total stock-based compensation expense |
4,245
|
3,540
|
8,094
|
7,219
|
General and administrative |
|
|
|
|
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
|
|
|
|
Total stock-based compensation expense |
$ 2,008
|
$ 1,756
|
$ 3,795
|
$ 3,185
|
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v3.23.2
LICENSE AND GRANT REVENUES - License and Collaboration Agreements (Details)
|
|
1 Months Ended |
3 Months Ended |
6 Months Ended |
|
Jul. 24, 2023
USD ($)
|
Jun. 30, 2022
USD ($)
program
|
Jul. 31, 2020
USD ($)
compound
performanceObligation
|
Jun. 30, 2020
USD ($)
program
performanceObligation
|
Aug. 31, 2019
USD ($)
performanceObligation
|
Jun. 30, 2023
USD ($)
|
Jun. 30, 2022
USD ($)
program
|
Jun. 30, 2023
USD ($)
|
Jun. 30, 2022
USD ($)
program
|
Dec. 31, 2022
USD ($)
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Deferred revenue |
|
|
|
|
|
$ 119,000
|
|
$ 119,000
|
|
$ 166,000
|
Total revenue |
|
|
|
|
|
30,000
|
$ 711,000
|
47,000
|
$ 1,640,000
|
|
License fee revenue from non-affiliates |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Total revenue |
|
|
|
|
|
30,000
|
711,000
|
47,000
|
1,626,000
|
|
Phylaxis BioScience, LLC |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Equity interest percentage |
|
|
10.00%
|
|
|
|
|
|
|
|
Additional equity interest percentage entitled to receive |
|
|
5.00%
|
|
|
|
|
|
|
|
Chiesi Farmaceutici S.p.A. |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Nonrefundable, upfront payment |
|
|
|
|
$ 10,000,000
|
|
|
|
|
|
Additional payable due from agreement |
|
|
|
|
12,500,000
|
|
|
|
|
|
Milestone payments receivable |
|
|
|
|
$ 122,500,000
|
|
|
|
|
|
Number of performance obligations | performanceObligation |
|
|
|
|
1
|
|
|
|
|
|
Term of research and development services option period |
|
|
|
|
60 days
|
|
|
|
|
|
Deferred revenue |
|
|
|
|
|
100,000
|
|
100,000
|
|
100,000
|
Chiesi Farmaceutici S.p.A. | Subsequent Event |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Term of option period due from deliverables |
60 days
|
|
|
|
|
|
|
|
|
|
Nonrefundable, option exercise payment |
$ 12,500,000
|
|
|
|
|
|
|
|
|
|
Chiesi Farmaceutici S.p.A. | License fee revenue from non-affiliates |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Revenue recognized related to performance obligation |
|
|
|
|
|
17,000
|
100,000
|
47,000
|
300,000
|
|
Total revenue |
|
|
|
|
|
30,000
|
98,000
|
47,000
|
339,000
|
|
Phylaxis BioScience, LLC |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Nonrefundable, upfront payment |
|
|
$ 2,500,000
|
|
|
|
|
|
|
|
Additional payable due from agreement |
|
|
$ 2,500,000
|
|
|
|
|
|
|
|
Number of performance obligations | performanceObligation |
|
|
1
|
|
|
|
|
|
|
|
Deferred revenue |
|
|
|
|
|
0
|
|
0
|
|
$ 0
|
Additional payment receivable period |
|
|
180 days
|
|
|
|
|
|
|
|
Development milestone payment receivable |
|
|
$ 225,000,000
|
|
|
|
|
|
|
|
Commercialization milestone payment receivable |
|
|
175,000,000
|
|
|
|
|
|
|
|
Equity method investment |
|
|
500,000
|
|
|
|
|
|
|
|
Payments due pursuant to agreement |
|
|
$ 5,000,000
|
|
|
|
|
|
|
|
Number of compounds | compound |
|
|
2
|
|
|
|
|
|
|
|
Phylaxis BioScience, LLC | Payment One |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Additional payable due from agreement |
|
|
$ 1,250,000
|
|
|
|
|
|
|
|
Phylaxis BioScience, LLC | Payment Two |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Additional payable due from agreement |
|
|
$ 1,250,000
|
|
|
|
|
|
|
|
Phylaxis BioScience, LLC | License fee revenue from non-affiliates |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Revenue recognized related to performance obligation |
|
|
|
|
|
0
|
400,000
|
0
|
1,100,000
|
|
Total revenue |
|
|
|
|
|
0
|
$ 413,000
|
0
|
$ 1,087,000
|
|
2seventy bio, Inc. | Initial Programs |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Nonrefundable, upfront payment |
|
|
|
$ 400,000
|
|
|
|
|
|
|
Number of performance obligations | performanceObligation |
|
|
|
1
|
|
|
|
|
|
|
Number of program related to collaborative agreement | program |
|
3
|
|
2
|
|
|
3
|
|
3
|
|
2seventy bio, Inc. | Additional Programs |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Number of program related to collaborative agreement | program |
|
|
|
8
|
|
|
|
|
|
|
2seventy bio, Inc. | Initial Programs, Program 1 |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Nonrefundable, upfront payment |
|
|
|
$ 200,000
|
|
|
|
|
|
|
2seventy bio, Inc. | Initial Programs, Program 2 |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Nonrefundable, upfront payment |
|
|
|
200,000
|
|
|
|
|
|
|
2seventy bio, Inc. | Initial Programs, Program 3 |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Nonrefundable, upfront payment |
|
$ 200,000
|
|
|
|
|
|
|
|
|
2seventy bio, Inc. | 2020 Option and License Agreement |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Development milestone payment receivable |
|
|
|
$ 51,500,000
|
|
|
|
|
|
|
2seventy bio, Inc. | License fee revenue from non-affiliates |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Total revenue |
|
|
|
|
|
0
|
$ 200,000
|
0
|
$ 200,000
|
|
2seventy bio, Inc. | License fee revenue from non-affiliates | 2020 Option and License Agreement |
|
|
|
|
|
|
|
|
|
|
Collaborative Arrangements And Noncollaborative Arrangement Transactions Line Items |
|
|
|
|
|
|
|
|
|
|
Total revenue |
|
|
|
|
|
$ 0
|
$ 200,000
|
$ 0
|
$ 200,000
|
|
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v3.23.2
COMMITMENTS AND CONTINGENCIES - Narrative (Details) - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
|
|
|
Jun. 30, 2023 |
Jun. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Dec. 31, 2022 |
May 31, 2019 |
Sep. 30, 2017 |
Commitments and Contingencies Disclosure [Abstract] |
|
|
|
|
|
|
|
Lease agreement term |
|
|
|
|
|
|
7 years
|
Lease extension term |
|
|
|
|
|
|
5 years
|
Initial base rent per month |
|
|
|
|
|
$ 30
|
$ 100
|
Annual escalations |
|
|
|
|
|
2.00%
|
2.00%
|
Operating lease expense |
$ 800
|
$ 800
|
$ 1,700
|
$ 1,600
|
|
|
|
Payments included in measurement of lease liability |
$ 500
|
500
|
$ 1,100
|
1,100
|
|
|
|
Remaining term of operating lease |
2 years
|
|
2 years
|
|
2 years 6 months
|
|
|
Weighted-average discount rate |
8.20%
|
|
8.20%
|
|
8.20%
|
|
|
Purchase commitment, future period |
|
|
12 months
|
|
|
|
|
Purchase commitment |
$ 76,500
|
|
$ 76,500
|
|
$ 74,800
|
|
|
Purchase commitment, expenses incurred |
$ 1,000
|
$ 600
|
$ 1,000
|
$ 600
|
|
|
|
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COMMITMENTS AND CONTINGENCIES - Schedule of Right-Of-Use Asset and Operating Lease Liability (Details) - USD ($) $ in Thousands |
Jun. 30, 2023 |
Dec. 31, 2022 |
Commitments and Contingencies Disclosure [Abstract] |
|
|
Right-of-use asset |
$ 3,853
|
$ 4,717
|
Operating lease liability |
|
|
Current |
1,959
|
1,860
|
Non-current |
2,171
|
3,173
|
Present value of operating lease liability |
$ 4,130
|
$ 5,033
|
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Jun. 30, 2023 |
Dec. 31, 2022 |
Commitments and Contingencies Disclosure [Abstract] |
|
|
2023 |
$ 1,110
|
|
2024 |
2,247
|
|
2025 |
1,137
|
|
Thereafter |
0
|
|
Total future minimum lease payments |
4,494
|
|
Less: imputed interest |
(364)
|
|
Present value of operating lease liability |
4,130
|
$ 5,033
|
Less: current portion of operating lease liability |
(1,959)
|
(1,860)
|
Non-current portion of lease liability |
$ 2,171
|
$ 3,173
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