RNS Number:4223N
British Biotech PLC
10 July 2003


                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Name of company

British Biotech plc

2. Name of shareholder having a major interest

Amvescap plc

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Notification is in respect of an interest on behalf of discretionary managed
clients of Amvescap plc. By virtue of the Companies Act Section 203 Amvescap is
deemed to have the same interest in the shares

4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Vidacos Nominees Ltd                                                10,153,379
HSBC Nominees Ltd                                                    2,646,363
Chase Nominees Ltd                                                     372,389
Bank of New York Nominees Ltd                                          941,766
Northern Trust Nominees Ltd                                            178,870
CM Investment Nominees Ltd                                               1,718

5. Number of shares / amount of stock acquired

562,053

6. Percentage of issued class

0.84 per cent

7. Number of shares / amount of stock disposed

n/a

8. Percentage of issued class

n/a

9. Class of security

Ordinary 5p shares

10. Date of transaction

9 July, 2003

11. Date company informed

10 July, 2003

12. Total holding following this notification

14,294,485

13. Total percentage holding of issued class following this notification

21.41 per cent

14. Any additional information

Amvescap advises that this shareholding includes the following notifiable
holdings:
INVESCO Perpetual High Income Fund, which holds 3,147,565 shares (4.71 per cent)
and INVESCO Perpetual UK Growth Fund, which holds 2,181,250 shares (3.26 per
cent), both of which are registered in the name of Vidacos Nominees Ltd; and
St James' Place Net Income Distribution Fund, which holds 2,039,777 shares (3.05
per cent) registered in the name of HSBC Nominees Ltd.

15. Name of contact and telephone number for queries

Tony Weir, Finance Director, + 44 1 865 781166

16. Name and signature of authorised company official responsible for making
this notification

Stephen Powers

Date of notification

10 July, 2003

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The FSA is not liable for any damages (including, without limitation, damages
for loss of business or loss of profits) arising in contract, tort or otherwise
from the use of or inability to use this document, or any material contained in
it, or from any action or decision taken as a result of using this document or
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