RNS Number:5177U
Protherics PLC
22 January 2004


                         Protherics PLC ("Protherics")

                              Directors' Dealings

Protherics announces that on 21 January 2004, B M Riley exercised options over
72,011 ordinary shares of 2p each (comprising 0.03% of the Protherics issued
share capital after enlargement by the exercise). The options, issued under the
Protherics Unapproved Share Option Scheme, had an exercise price of 41.66p per
share, and an expiry date of 22 January 2004.

Application is being made to the UK Listing Authority and to the London Stock
Exchange for these shares to be admitted to the Official List and to trading on
the London Stock Exchange's market for listed securities ("Admission"). It is
expected that Admission will occur on 28 January 2004.

Barry Riley also contracted on 21 January 2004 to sell 60,274 of the shares he
received upon the exercise of the options (representing 0.03% of the enlarged
share capital) at a price of 57.75p per share. The net proceeds of the sale will
be used to settle the tax due on the exercise of the options and to fund the
purchase of the remaining 11,737 shares. The Company was informed of this sale
on 21 January 2004.

Barry Riley retains options over 837,955 ordinary shares of 2p each at exercise
prices of between 23.25 and 68.83 p per share, which expire between 24 July 2005
and 20 June 2013.

Following the above transactions, he will be interested in a further 11,737
ordinary shares of 2p each in addition to the 15,554 previously held, and
#15,151 nominal value of Protherics PLC 6% Convertible Unsecured Loan Notes
2010.




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