RNS Number:9539K
Acambis PLC
12 May 2003


                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company


Acambis plc



2. Name of shareholder having a major interest


Morley Fund Management Limited (a subsidiary of Aviva plc)



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18


As above



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them


BNY Norwich Union Nominees Ltd 670,684 shares

Chase GA Group Nominees Ltd 2,268,663 shares

Chase Nominees Ltd 197,407 shares

CUIM Nominees Ltd 751,812 shares

RBSTB Nominees Ltd 131,709 shares



5. Number of shares / amount of stock acquired






6. Percentage of issued class






7. Number of shares / amount of stock disposed


250,000



8. Percentage of issued class


0.24%



9. Class of security


Ordinary shares of 10p each



10. Date of transaction


8 May 2003



11. Date company informed


9 May 2003



12. Total holding following this notification


4,020,275



13. Total percentage holding of issued class following this notification


3.87%



14. Any additional information


N/A



15. Name of contact and telephone number for queries


Elizabeth Brown, Company Secretary

+44 (0) 1223 275 300



16. Name and signature of authorised company official responsible for making
this notification


Elizabeth Brown



Date of notification


12 May 2003



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