Arix Bioscience PLC: Autolus presents additional AUTO3 data in DLBCL (1133459)
September 18 2020 - 2:57AM
UK Regulatory
Arix Bioscience PLC (ARIX)
Arix Bioscience PLC: Autolus presents additional AUTO3 data in DLBCL
18-Sep-2020 / 08:57 GMT/BST
Dissemination of a Regulatory Announcement, transmitted by EQS Group.
The issuer is solely responsible for the content of this announcement.
Arix Bioscience plc
Autolus presents additional AUTO3 data in DLBCL
LONDON, 18 September 2020: Arix Bioscience plc (LSE:ARIX) ("Arix"), a global
venture capital company focused on investing in and building breakthrough
biotech companies, notes that its portfolio company Autolus Therapeutics plc
("Autolus") (Nasdaq: AUTL), announced new data highlighting progress on
AUTO3, the company's CAR T cell therapy being investigated in a Phase 1/2
clinical trial in relapsed/refractory diffuse large B cell lymphoma (DLBCL),
during the European Society for Medical Oncology (ESMO) Virtual Congress
2020, beginning 18 September.
The announcement can be accessed on Autolus' investor website at
https://www.autolus.com/investor-relations [1] and full text of the
announcement from Autolus is contained below. Autolus management will host a
conference call and webcast today at 8:00 am EDT/1:00 pm BST to discuss the
ESMO data. To listen to the webcast and view the accompanying slide
presentation, please go to:
https://www.autolus.com/investor-relations/news-and-events/events [2].
[S]
Enquiries
For more information on Arix, please contact:
Arix Bioscience plc
Charlotte Parry, Head of Investor Relations
+44 (0)20 7290 1072
charlotte@arixbioscience.com
Optimum Strategic Communications
Mary Clark, Supriya Mathur, Shabnam Bashir
+44 (0)20 3714 1787
optimum.arix@optimumcomms.com
About Arix Bioscience plc
Arix Bioscience plc is a global venture capital company focused on investing
in and building breakthrough biotech companies around cutting edge advances
in life sciences. We collaborate with exceptional entrepreneurs and provide
the capital, expertise and global networks to help accelerate their ideas
into important new treatments for patients. As a listed company, we are able
to bring this exciting growth phase of our industry to a broader range of
investors.
Arix Bioscience plc is listed on the Main Market of the London Stock
Exchange. For further information, please visit www.arixbioscience.com
Autolus Therapeutics presents additional data on AUTO3 in DLBCL during the
ESMO Virtual Congress 2020 [3]
? AUTO3 shows promise of a highly differentiated product profile
Conference call and webcast to be held Friday, September 18, 2020 at 8:00 am
EDT / 1:00 pm BST
LONDON, September 18, 2020 -- Autolus Therapeutics plc (Nasdaq: AUTL), a
clinical-stage biopharmaceutical company developing next-generation
programmed T cell therapies, today announced new data highlighting progress
on AUTO3, the company's CAR T cell therapy being investigated in the
ALEXANDER study, a Phase 1/2 clinical trial in relapsed/refractory diffuse
large B cell lymphoma (DLBCL), during the European Society for Medical
Oncology (ESMO) Virtual Congress 2020, beginning 18 September.
"Today we presented data from our recommended Phase 2 dose cohort from the
ALEXANDER trial of AUTO3, a CD19 and CD22 dual targeting CAR T product
candidate in DLBCL. The data support a best in class profile with a high
level of complete remissions and a well tolerated safety profile," said Dr.
Christian Itin, chairman and chief executive officer of Autolus.
"AUTO3 has a tolerable and very favorable safety profile when compared with
approved CD19 CAR T therapies," said Dr Craig Moskowitz, Professor of
Medicine at Miller School of Medicine, University of Miami Health System.
"It has a promising complete response rate of 64%, as demonstrated in the
completed cohorts at the recommended Phase 2 dose range and, thus far, these
complete remissions also appear durable. Among all dose cohorts with a
median follow up of 6 months, 93% of the patients who achieved a complete
response did not relapse."
As of the data cut-off date of August 3, 2020, 35 patients in the ALEXANDER
Phase 1/2 clinical trial of AUTO3 have been treated and were evaluable for
safety. AUTO3 was well tolerated, with no Grade 3 or higher cytokine release
syndrome (CRS) with primary infusion and low rates of neurotoxicity (NT).
Across all 35 patients, only three cases of NT have been reported, with two
having >= Grade 3. Among the 20 patients treated at a dose of >= 150 x 106
cells with pre-conditioning pembrolizumab on day minus 1 (D-1), which is the
declared recommended Phase 2 dose (RP2D), one patient experienced >=Grade 3
NT (patient died due to disease progression and multiorgan failure). None of
the patients achieving a complete response (CR) experienced any NT and all
cases of NT reported have been atypical in nature and seen in a setting with
disease progression and confounding factors.
In terms of efficacy data, of the 35 patients dosed to date, 30 patients
were evaluable within their completed cohort. The cohort receiving a dose of
>= 150 x 106 cells and pre-conditioning pembrolizumab D-1 (the RP2D) had an
objective response rate (ORR) of 71% and CR rate of 64%. For all patients on
study across all dose levels that were evaluable, the ORR was 68% and CR
rate of 54%.
Investor call on Friday September 18, 2020
Management will host a conference call and webcast today at 8:00 am EDT/1:00
pm BST to discuss the ESMO data. To listen to the webcast and view the
accompanying slide presentation, please go to:
https://www.autolus.com/investor-relations/news-and-events/events [4]. The
call may also be accessed by dialing (866) 652-5200 for U.S. and Canada
callers or (412) 317-6060 for International callers. Please ask to be joined
into the Autolus Therapeutics call. After the conference call, a replay will
be available for one year on Autolus' website.
About Autolus Therapeutics plc
Autolus is a clinical-stage biopharmaceutical company developing
next-generation, programmed T cell therapies for the treatment of cancer.
Using a broad suite of proprietary and modular T cell programming
technologies, the company is engineering precisely targeted, controlled and
highly active T cell therapies that are designed to better recognize cancer
cells, break down their defense mechanisms and eliminate these cells.
Autolus has a pipeline of product candidates in development for the
treatment of hematological malignancies and solid tumors. For more
information please visit www.autolus.com.
About AUTO3
AUTO3 is a programmed T cell therapy containing two independent chimeric
antigen receptors targeting CD19 and CD22 that have each been independently
optimized for single target activity. By simultaneously targeting two B cell
antigens, AUTO3 is designed to minimize relapse due to single antigen loss
in patients with B cell malignancies. AUTO3 is currently being tested in
diffuse large B cell lymphoma in the ALEXANDER clinical trial, with a
20-patient cohort that was initiated in Q2 2020 to assess feasibility of
treatment in an outpatient setting.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of
the "safe harbor" provisions of the Private Securities Litigation Reform Act
of 1995. Forward-looking statements are statements that are not historical
facts, and in some cases can be identified by terms such as "may," "will,"
"could," "expects," "plans," "anticipates," and "believes." These statements
include, but are not limited to, statements regarding the efficacy, safety
and therapeutic potential of AUTO3 and the future clinical development of
AUTO3 including progress, expectations as to the reporting of data, conduct
and timing. Any forward-looking statements are based on management's current
views and assumptions and involve risks and uncertainties that could cause
actual results, performance or events to differ materially from those
expressed or implied in such statements. These risks and uncertainties
include, but are not limited to, the risks that Autolus' preclinical or
clinical programs do not advance or result in approved products on a timely
or cost effective basis or at all; the results of early clinical trials are
not always being predictive of future results; the cost, timing and results
of clinical trials; that many product candidates do not become approved
drugs on a timely or cost effective basis or at all; the ability to enroll
patients in clinical trials; possible safety and efficacy concerns; and the
impact of the ongoing COVID-19 pandemic on Autolus' business. For a
discussion of other risks and uncertainties, and other important factors,
any of which could cause Autolus' actual results to differ from those
contained in the forward-looking statements, see the section titled "Risk
Factors" in Autolus' Annual Report on Form 20-F filed with the Securities
and Exchange Commission on March 3, 2020, as amended, as well as discussions
of potential risks, uncertainties, and other important factors in Autolus'
subsequent filings with the Securities and Exchange Commission. All
information in this press release is as of the date of the release, and the
company undertakes no obligation to publicly update any forward-looking
statement, whether as a result of new information, future events, or
otherwise, except as required by law.
Contact:
Lucinda Crabtree, PhD
Vice President, Investor Relations and Corporate Communications
+44 (0) 7587 372 619
l.crabtree@autolus.com
Julia Wilson
+44 (0) 7818 430877
j.wilson@autolus.com
Susan A. Noonan
S.A. Noonan Communications
+1-212-966-3650
susan@sanoonan.com
# # #
ISIN: GB00BD045071
Category Code: MSCH
TIDM: ARIX
LEI Code: 213800OVT3AHQCXNIX43
Sequence No.: 84398
EQS News ID: 1133459
End of Announcement EQS News Service
1: https://eqs-cockpit.com/cgi-bin/fncls.ssp?fn=redirect&url=4ecf88d4c2d4576a71c14feabea68052&application_id=1133459&site_id=vwd&application_name=news
2: https://eqs-cockpit.com/cgi-bin/fncls.ssp?fn=redirect&url=4767ee3ff61f1c03a6b25582a4349f00&application_id=1133459&site_id=vwd&application_name=news
3: https://eqs-cockpit.com/cgi-bin/fncls.ssp?fn=redirect&url=a6493e758cffd47948c4e5713770f47f&application_id=1133459&site_id=vwd&application_name=news
4: https://eqs-cockpit.com/cgi-bin/fncls.ssp?fn=redirect&url=692e09671580f15b5c593071330f93ca&application_id=1133459&site_id=vwd&application_name=news
(END) Dow Jones Newswires
September 18, 2020 03:57 ET (07:57 GMT)
Arix Bioscience (LSE:ARIX)
Historical Stock Chart
From Apr 2024 to May 2024
Arix Bioscience (LSE:ARIX)
Historical Stock Chart
From May 2023 to May 2024