Cambridge Cognition Holdings PLC CANTAB used in EBBINGHAUS cognitive function trial
March 16 2017 - 2:01AM
RNS Non-Regulatory
TIDMCOG
Cambridge Cognition Holdings PLC
16 March 2017
Cambridge Cognition Holdings Plc
('Cambridge Cognition' or the 'Company')
CANTAB(R) assessments used in EBBINGHAUS cognitive function
trial for Amgen's evolocumab
16 March 2017: The neuroscience digital health company Cambridge
Cognition Holdings PLC (Cambridge, UK - LSE: COG), which develops
and markets software products to improve brain health, today
reports its involvement in Amgen's EBBINGHAUS study with full
results being presented at the American College of Cardiology
Annual Scientific Session on 18 March 2017.
The EBBINGHAUS researchers used Cambridge Cognition's CANTAB(R)
digital cognitive assessments, an industry standard for cognitive
outcomes measurement. CANTAB products are designed to improve data
quality and operational efficiencies in large multinational
clinical trials such as this.
Amgen recently announced positive results of the FOURIER and
EBBINGHAUS trials evaluating the human anti-PCSK9 monoclonal
antibody evolocumab (Repatha(R) ). The EBBINGHAUS trial is the
first of its kind to prospectively explore the relationship between
very low LDL cholesterol levels and neurocognitive function(*)
.
The FOURIER trial conducted in 27,564 patients with clinically
evident atherosclerotic cardiovascular disease (ASCVD) found
evolocumab reduced the risk of cardiovascular events, by reducing
high levels of LDL cholesterol. The EBBINGHAUS cognitive function
trial conducted in a subset of 1,974 FOURIER patients also achieved
its primary endpoint, demonstrating that evolocumab was
non-inferior to placebo for the effect on cognitive function.
Kenton Zavitz PhD, Director of Clinical Affairs, Cambridge
Cognition commented: "By all measures EBBINGHAUS is a landmark
cognitive study. The study involved 1,974 patients across 30
countries worldwide using our tablet-based CANTAB cognitive
technology. Researchers were able to reliably assess study subjects
for effects on executive function, memory, and psychomotor speed at
baseline and select time points. CANTAB software enabled
assessments to be carried out in a patient-friendly manner and
ensure consistent and reliable data capture that could be
translated into meaningful results, without the need for a
specialist in neuropsychology at each trial site."
Full results from the evolocumab EBBINGHAUS cognitive function
trial will be presented at the American College of Cardiology (ACC)
66th Annual Scientific Session Late-Breaking Clinical Trials
session on Saturday, March 18, 2017 at 9 a.m. ET.
Notes to editors
EBBINGHAUS Study Design
EBBINGHAUS (Evaluating PCSK9 Binding antiBody Influence oN
coGnitive HeAlth in high cardiovascUlar risk Subjects) is a
double-blind, placebo-controlled randomized non-inferiority trial
involving 1,974 patients enrolled in the FOURIER outcomes study.
The primary endpoint in the study is the Spatial Working Memory
strategy index of executive function. Secondary endpoints are
working memory, as assessed by the CANTAB Spatial Working Memory
(SWM) test between-errors score; memory function, as assessed by
the CANTAB Paired Associates Learning (PAL) test; and psychomotor
speed, as assessed by the CANTAB Reaction Time (RTI) test.
For further information about this study, you may be interested
in reading the following paper:
*Giugliano R.P., et al. (2017) Design and rationale of the
EBBINGHAUS trial: A phase 3, double-blind, placebo-controlled,
multicenter study to assess the effect of evolocumab on cognitive
function in patients with clinically evident cardiovascular disease
and receiving statin background lipid-lowering therapy-A cognitive
study of patients enrolled in the FOURIER trial. Clinical
Cardiology, 2017.
http://onlinelibrary.wiley.com/doi/10.1002/clc.22678/full
About Cambridge Cognition Holdings PLC
Cambridge Cognition is a neuroscience digital health company
developing products and services to better understand, detect and
treat conditions affecting brain health. Our cognitive research
technologies for mobile, wearable, and online platforms accelerate
the research and development of new treatments, enhance research of
the brain, and measure cognitive health and wellbeing in patients
worldwide.
www.cambridgecognition.com
Enquiries
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