ChemGenex’s Omacetaxine to be Showcased in Three Oral Presentations at EHA
May 21 2009 - 6:00AM
Business Wire
ChemGenex Pharmaceuticals Limited (ASX:CXS) (NASDAQ:CXSP)
announced today that new data from two clinical studies and one
pre-clinical study with omacetaxine will be presented at oral
sessions during the forthcoming 14th Congress of the European
Hematology Association (EHA) in Berlin, Germany.
The latest clinical data from the pivotal study on the use of
omacetaxine in chronic myeloid leukemia (CML) patients who harbor
the T315I mutation, will be given at 8:00 am on Saturday June 6th
by Dr. Mauricette Michallet, Department of Hematology, H�pital
Edouard Herriot, Lyon, France.
Interim data from the company�s complementary phase 2 study
investigating the potential use of omacetaxine in CML patients with
resistance to multiple tyrosine kinase inhibitors (TKIs), will be
presented at 8:15 am on Saturday June 6th by Dr. Meir Wetzler MD,
Chief of the Division of Leukemia, School of Medicine and
Biomedical Sciences, University at Buffalo, Roswell Park Cancer
Institute.
Finally Dr. Elaine Allen, Clinical Scientist at the Paul
O'Gorman Leukaemia Research Centre, University of Glasgow in
Scotland, UK, will present the results of a collaborative project
investigating the ability of omacetaxine to kill human malignant
CML stem cells which are insensitive to the tyrosine kinase
inhibitors currently used to treat CML. This will take place at
8:30 am on Sunday June 7th.
Commenting on today�s publication of the final program for EHA,
Dr Greg Collier, Ph.D., Managing Director and Chief Executive
Officer of ChemGenex, said, �We are delighted that three studies on
our late stage product candidate, omacetaxine, are being
highlighted as oral presentations at this prestigious international
conference. This outstanding achievement is testimony to the
efforts of our clinical and academic collaborators across the
globe, and we thank them for their ongoing support as we work to
complete the US and European regulatory submissions for omacetaxine
over coming months.�
About Omacetaxine
Omacetaxine mepesuccinate is a first-in-class cetaxine with
demonstrated clinical activity as a single agent in a range of
hematological malignancies. Omacetaxine has a novel mechanism of
action, and induces apoptosis by inhibition of protein synthesis,
particularly Mcl-1. As omacetaxine acts independently of tyrosine
kinase inhibitors, it may have a therapeutic advantage for patients
who have developed resistance to TKIs. Omacetaxine is administered
subcutaneously.
About ChemGenex Pharmaceuticals Limited
(http://www.chemgenex.com)
ChemGenex Pharmaceuticals is a pharmaceutical development
company dedicated to improving the lives of patients by developing
personalized oncology medicines. ChemGenex harnesses the power of
genomics both to discover novel targets and drug compounds, and in
clinical trials to develop more individualized treatment outcomes.
ChemGenex�s lead compound, omacetaxine mepesuccinate, is currently
in phase 2/3 clinical trials for chronic myeloid leukemia (CML).
ChemGenex has a second anticancer compound, amonafide
dihydrochloride (Quinamed�) which is in phase 2 clinical
development for various solid cancers, and a portfolio of assets in
pre-clinical development. ChemGenex currently trades on the
Australian Stock Exchange under the symbol "CXS" and on NASDAQ
under the symbol "CXSP". For additional information on ChemGenex
Pharmaceuticals, please visit our web site at
http://www.chemgenex.com.
Details on the clinical trials can be accessed from the
following websites:
http://clinicaltrials.gov/ct2/show/NCT00375219?term=homoharringtonine&rank=9
and http://www.tkiresistantcmltrials.com
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