false
0000744452
0000744452
2024-01-08
2024-01-08
iso4217:USD
xbrli:shares
iso4217:USD
xbrli:shares
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 8-K
CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934
Date of Report (Date of earliest event reported):
January 8, 2024
Applied DNA Sciences, Inc.
(Exact name of registrant as specified in its charter)
|
Delaware
(State or other jurisdiction
of incorporation) |
001-36745
(Commission File Number) |
59-2262718
(IRS Employer
Identification No.) |
50 Health Sciences Drive
Stony Brook, New York 11790
(Address of principal executive offices; zip code)
Registrant’s telephone number, including
area code:
631-240-8800
N/A
(Former name or former address, if changed since
last report)
Check the appropriate box below if the Form 8-K
filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
| ¨ |
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
| ¨ |
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
| ¨ |
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
| ¨ |
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Indicate by check mark whether the
registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or
Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter). Emerging growth company ¨
If an emerging growth company, indicate by check
mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards provided pursuant to Section 13(a) of the Exchange Act. ¨
Securities registered pursuant to Section 12(b)
of the Act:
| Title of each class |
|
Trading Symbol(s) |
|
Name of each exchange on which registered |
| Common Stock, $0.001 par value |
|
APDN |
|
The
Nasdaq Stock Market
|
| Item 7.01 |
Regulation FD Disclosure. |
On January 8, 2024, Applied
DNA Sciences, Inc. (the “Company”) intends to make presentations entitled “A Next Generation Platform for Genetic Medicine
Manufacturing” to investors and analysts attending various conferences in San Francisco, California. The presentation is available
on the Company’s website at www.adnas.com and it may also be used in presentations to investors and analysts from time to time in
the future. A copy of the Company’s presentation is attached hereto as Exhibit 99.1 and is incorporated herein by reference.
The information contained
in this Current Report on Form 8-K speaks only as of the date hereof. While the Company may elect to update the information
in this Current Report on Form 8-K in the future, the Company disclaims any obligation to do so except to the extent required
by applicable law.
The information furnished
in this Item 7.01 of this Current Report on Form 8-K and Exhibit 99.1 attached hereto shall not be deemed “filed”
for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise
subject to the liabilities of that section. The information in this Item 7.01 of this Current Report on Form 8-K is not incorporated
by reference into any filings of the Company made under the Securities Act of 1933, as amended, or the Exchange Act, whether made before
or after the date of this Current Report on Form 8-K, regardless of any general incorporation language in the filing unless
specifically stated so therein.
| Item 9.01 |
Financial Statements and Exhibits. |
(d) Exhibits
SIGNATURE
Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.
| Date: January 8, 2024 |
APPLIED DNA SCIENCES, INC. |
| |
|
|
| |
By: |
/s/ James A. Hayward |
| |
Name: |
James A. Hayward |
Exhibit 99.1
A Next Generation Platform for Genetic Medicine Manufacturing Nasdaq: APDN
The statements made by Applied DNA in this presentation may be “forward - looking” in nature within the meaning of Section 27 A of the Securities Act of 1933 , Section 21 E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995 . Forward - looking statements describe Applied DNA’s future plans, projections, strategies, and expectations, and are based on assumptions and involve a number of risks and uncertainties, many of which are beyond the control of Applied DNA . Actual results could differ materially from those projected due to its history of net losses, limited financial resources, unknown future demand for its biotherapeutics products and services, the unknown amount of revenues and profits that will result from the Linea DNA and/or Linea IVT platforms, limited market acceptance for its supply chain security products and services, our unknown ability to procure additional financing to build our GMP manufacturing facility, the declining demand for Applied DNA’s COVID - 19 testing services, the fact that there has never been a commercial drug product utilizing PCR - produced DNA technology and/or the Linea DNA or Linea IVT platforms approved for therapeutic use, and various other factors detailed from time to time in Applied DNA’s SEC reports and filings, including its Annual Report on Form 10 - K filed on December 7 , 2023 , and other reports it files with the SEC, which are available at www . sec . gov . Applied DNA undertakes no obligation to update publicly any forward - looking statements to reflect new information, events, or circumstances after the date hereof or to reflect the occurrence of unanticipated events, unless otherwise required by law . 2 ©2024 Applied DNA Sciences, Inc. Safe Harbor Statement
Company Overview • 3 interrelated business segments all leveraging the polymerase chain reaction (PCR) to enable manufacture and analysis of DNA - Therapeutic DNA Production - MDx and Genetic Testing - DNA Tagging and Authentication • 15 years of experience in enzymatic DNA production • Growth in genetic medicine development pipelines accelerated pivot to therapeutic DNA production • 55 employees located in 30,000 sq. ft. facility in Stony Brook, New York ©2024 Applied DNA Sciences, Inc. 3 ©2024 Applied DNA Sciences, Inc.
I n v es t m e nt Highlights • Pioneering enzymatic therapeutic DNA production for next generation genetic medicines as a direct replacement for plasmid DNA (pDNA) • Patented and patent - pending expertise in the production of DNA via PCR at very large scale • The largest enzymatic DNA manufacturing company in North America • Initial opportunity: critical starting material for mRNA therapeutics • Proprietary platform combining two mRNA critical starting materials outclasses conventional production methods • Marquee RUO - scale customer base: from Big Pharma to CDMOs • Imminent, Potential Near - Term Catalysts (CY2024) 4 ©2024 Applied DNA Sciences, Inc.
Q1’CY24 Q2’CY24 Q3’CY24 Q4’CY24 Initiate pursuit of FDA Advanced Manufacturing Technology Designation 1 Launch GMP manufacturing capacity for mRNA critical starting materials 2 Anticipate signing supply agreements for Linea DNA IVT templates/Linea IVT platform Anticipate PGx test approval 3 ; launch of testing service Anticipate initiation of new cotton supply chain 1 Proposed designation announced by FDA in December 2023. Pursuit contingent upon final approval of program by FDA 2 Subject to future ability to raise necessary capital 3 Approval contingent on length of New York State Department of Health review that is outside of the control of the Company Multiple Potential Near - Term Catalysts (CY24) 5 ©2024 Applied DNA Sciences, Inc.
Genetic Medicine Starts with DNA Broad Relevance to a Rapidly Growing Opportunity Over 3,800 genetic medicines in development, almost all in early stages 350 mRNA therapies in development - over 68% still in pre - clinical development Disease indications range from oncology, gene therapy, rare disease, autoimmune and vaccines mRNA manufacturing market forecasted to reach $22.6B in 2031 First sa - mRNA vaccine approved. mRNA RSV vaccine approval pending Source: Q3 2023 Gene, Cell & RNA Therapy Landscape, American Society of Gene and Cell Therapy, April 2023 Source: https:// www.globenewswire.com/en/news - release/2023/02/21/2612419/0/en/mRNA - Manufacturing - and - Synthesis - Services - Market - worth - 22 - 6 - Billion - by - 2031 - Driven - by - Increasing - Number - of - Clinical - Trials - InsightAce - Analytic.html 6 ©2024 Applied DNA Sciences, Inc.
Platform An Adaptable, Enabling Manufacturing Technology 7 ©2024 Applied DNA Sciences, Inc.
STEP 01 Obtain DNA Target Sequence and Design PCR Primers STEP 05 Provide Linea DNA to Customer STEP 04 Step 2 Perform High - Fidelity Large - Scale PCR STEP 03 Purify PCR Amplicons Pl a t fo r m Perform Analytical Characterization of PCR Amplicons Only 4 input ingredients 5 production steps Can be completed in under 2 weeks Uses enzymes and is 100% cell free Large yield in small footprint Uses scalable benchtop instruments Simple process is well suited to cGMP Platform DNA Made Simple 8 ©2024 Applied DNA Sciences, Inc.
Advantages over plasmid DNA (pDNA) Simplicity Simplify Genetic Medicine Manufacturing Purity Produce Only the DNA You Want Speed Milligrams in 14 days Grams in ≈ 30 days Flexibility Chemical Modifications Various templates Scalability Milligrams to Multi - Grams 9 ©2024 Applied DNA Sciences, Inc.
1 Observed via fidelity assay analysis of 3kb DNA construct 2 Based on analysis of 2.3kb and 9.5kb DNA constructs 3 Error rate analysis performed via deep read NGS Attribute Specification Physical Structure Double Stranded DNA (dsDNA) Size 100bp to 18,000bp Manufacturing Method PCR - 100% Enzymatic Homopolymer Capacity Up to 150nt with high homogeneity % Target DNA Sequence 100% Ready to use for IVT Yes Sequence Fidelity • Observed amplification system fidelity of 66x of WT Taq 1 • Deep NGS sequencing (over 30k read depth) detected no variants as compared to parental pDNA template 2 • Resultant RNA fidelity meets or exceeds pDNA - based RNA 3 Manufacturing Speed • Milligrams in ≈2 weeks • Grams ≈ 30 days GMP Status Expected online in 1HCY2024 4 Fact Sheet 10 4 Subject to future ability to raise capital ©2024 Applied DNA Sciences, Inc.
Unparalleled Production Speed • Ultra - rapid DNA manufacturing • Little optimization needed for new DNA constructs • Optimal for R&D, drug discovery, clinical and commercial production workflows • Capable of using a broad range of template material 0 11 ©2024 Applied DNA Sciences, Inc. 20 40 60 80 Estimated Number of Manufacturing Days 1 00 Plasmid DNA Linea DNA (gram scale) - in silico template Linea DNA (gram scale) Linea DNA (milligram scale) - in silico template Linea DNA (miligram scale)
Success Across Genetic Medicine Modalities Oncology DNAVaccines GeneTherapy 12 ©2024 Applied DNA Sciences, Inc. CAR - T Manufacture Neoantigen DNA Vaccine LNP/DNA IM Administration Protective Prophylactic DNA Vaccine AAV ITR - Transgene Production
Selected Customer Profiles Broad Relevance Results in a Diverse Customer Base Gene Editing • Application - CRISPR - mediated homology directed repair (HDR) • Requirement - Linear dsDNA comprised of 100% target sequence at large scale • Outcome - Higher “knock - in” efficiencies than pDNA resulting in successful customer project and repeat orders Vaccines • Application - Self - amplifying mRNA (sa - mRNA) • Requirement - Linear dsDNA IVT template over 10kb in length with large homopolymer sequence • Outcome - Successful production of sa - mRNA template that customer could not reliability produce in pDNA. Repeat order obtained. In vitro Diagnostics • Application - Hepatic Cancer diagnostic • Requirement - Very large - scale dsDNA with chemical modifications • Outcome - Successful production of multiple grams of chemically modified dsDNA leading to long term supply contract Adoptive Cell Therapy • Application - CAR - T Therapy • Requirement - Non - viral DNA expression vector to produce anti - CD 19 CAR - T • Outcome - Successful production of CAR - T cells with high efficiencies and therapeutic index without the use of viral vectors or pDNA . Customer therapy slated for clinic in late CY 2024 13 ©2024 Applied DNA Sciences, Inc.
Better RNA…Faster 14 ©2024 Applied DNA Sciences, Inc.
Conventional mRNA Manufacturing Problems Long lead times increase mRNA production timeline 15 ©2024 Applied DNA Sciences, Inc. Struggles with complex DNA sequences such as Poly(A) tails Requires expensive enzymatic linearization and additional filtration steps Problematic inflammatory byproduct of conventional IVT dsRNA removal is essential for safe and effective mRNA products Increased regulatory scrutiny Currently mitigated via expensive and complex purification methods Defined by WHO as a hazardous byproduct that must be removed Increased regulatory scrutiny and QC issue Bacterially derived pDNA is currently the starting material for mRNA
Two Next Generation Technologies for Better mRNA • Secured via acquisition of Spindle Bio Inc. in July 2023 • Proprietary fusion enzyme comprised of a high fidelity RNAP and DNA binding domain • Chemically binds to Linea DNA IVT templates allowing unique IVT conditions that reduce or mitigate dsRNA • No impact on RNA fidelity • Pending IP in over 15 countries IVT Templates • Leverages platform advantages for 100% enzymatic production of IVT templates • Reduces up to 40% of the IVT steps used to manufacture mRNA • Homopolymers are added enzymatically providing homogeneous poly(a) sequence in mRNA • Chemical modification needed to enable Linea RNAP easily added 16 ©2024 Applied DNA Sciences, Inc.
Process step reduced or eli m i n a t ed b y L i n ea I V T Simplified mRNA Production 17 ©2024 Applied DNA Sciences, Inc.
0 30 60 90 1 20 2kb RNA 4.5kb RNA RNA Yield (µg) Linea IVT…. 1kb RNA WT T7 RNAP 1 kb 2 kb 4 . 5kb C o n t r ol 1 .4 1 .2 1 0 .8 0 .6 0 .4 0 .2 0 0 .1 ΔOD450 1 10 1 0 0 1 0 00 1 0 0 00 Amount of RNA Loaded (ng) Linea IVT dsRNA by J2 ELISA dsRNA Control WT T7 RNAP WT T7 RNAP ≈ 50x dsRNA Reduction from WT T7 dsRNA by J2 Dot Blot Lower dsRNA concentration results in lighter or no dot RNA Yields • Equal or greater yields than legacy RNA platforms with up to 50x dsRNA reduction • Minimal optimization required for new constructs Equal or Greater RNAYields with Mitigated dsRNA 18 ©2024 Applied DNA Sciences, Inc.
0 0.05 0.1 0.15 0.2 0.25 Control Linea IVT WT Linea IVT WT Linea IVT WT N e g a ti ve Control 1kb RNA 2kb RNA 4.5kb RNA NF - kB signaling (OD640) RNA Constructs (500ng) 4000 3500 3000 2500 2000 1500 1000 500 0 Control Linea IVT WT Linea IVT WT Linea IVT WT N e g a ti ve Control 1kb RNA 2kb RNA 4.5kb RNA IL - 8 signal (RLU) RNA Constructs (500ng) • dsRNA mitigated mRNA produced with Linea IVT reduced unwanted cellular immune stimulation in vitro to near negative control levels • mRNA produced with legacy platform showed significant unwanted cellular immune stimulation in vitro hTLR3 - SEAP reporter in HEK293 hTLR3 - Luc reporter in HEK293 Reduced Unwanted Cellular Immune Stimulation 19 ©2024 Applied DNA Sciences, Inc.
8.5 8.4 8.3 8.2 8.1 8 7.9 7.8 7.7 7.6 7.5 Linea IVT pDNA/WT Total # SNPs IVT Platform Average SNPs in RNA Construct 0.088 0.087 0.086 0.085 0.084 0.083 0.082 0.081 Linea IVT pDNA/WT Average Indel # per 1,000nt IVT Platform Average Indels per 1,000nt 4.4 4.35 4.3 4.25 4.2 4.15 4.1 4.05 4 Linea IVT pDNA/WT SNPs per 1,000nt IVT Platform Average SNPs per 1,000nt 99 99.3 99.6 99.9 Linea IVT pDNA/WT % correct base incorporation IVT platform Mean Correct Base Incorporation % High Fidelity RNA Production As compared to legacy IVT platforms (pDNA + wild type RNAP): • Statistically equivalent mean correct base incorporation rate • Lower average SNP errors • Lower average Indel errors • Lower overall SNP error in final RNA construct *Error rate and SNP/Indel analysis studies performed via deep read NGS dsRNA Mitigation Without Compromise 20 ©2024 Applied DNA Sciences, Inc.
$0 $2,000,000 $4,000,000 $6,000,000 $8,000,000 $10,000,000 10L 50L CDMO Batch Size 100L Potential Revenue per Batch Illustrative Linea IVT Potential Revenue per Selected mRNA Batch Sizes (10L, 50L and 100L)* GMP LineaDNA IVT Template Revenue GMP pDNA IVT Template Revenue Linea RNAP Revenue Linea IVT Revenue ** *Based on Company Internal Modeling and Current Industry Pricing ** Linea IVT revenue is Linea IVT template revenue + Linea RNAP revenue • RNAP is one of the most expensive COGs in mRNA manufacturing • Linea IVT templates enable the sale of Linea RNAP • Linea IVT potentially produces ≈3X the revenue opportunity compared to Linea IVT templates alone* • Linea IVT potentially produces ≈8x the revenue opportunity compared to pDNA IVT templates alone* Linea DNA is the Key to Unlocking Linea RNAP Value Capturing More mRNA Manufacturing COGs 21 ©2024 Applied DNA Sciences, Inc.
Financial Snapshot * $8.7 Million Market Cap 64,125 Average 3 - month daily share volume $7.2 Million C a s h /e q u i v a le n ts 13.7 Million Common shares outstanding 21.4 Million Fully diluted shares Capital Stock Series A Preferred: 10M authorized; 0 issued and outstanding Series B Preferred: 10M authorized; 0 issued and outstanding *As of closing price on 01.03.24 and Form 10 - K filed on 12/7/23 22 ©2024 Applied DNA Sciences, Inc.
Thank you! Nasdaq: APDN
v3.23.4
| X |
- DefinitionBoolean flag that is true when the XBRL content amends previously-filed or accepted submission.
| Name: |
dei_AmendmentFlag |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:booleanItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionFor the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD.
| Name: |
dei_DocumentPeriodEndDate |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:dateItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionThe type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.
| Name: |
dei_DocumentType |
| Namespace Prefix: |
dei_ |
| Data Type: |
dei:submissionTypeItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionAddress Line 1 such as Attn, Building Name, Street Name
| Name: |
dei_EntityAddressAddressLine1 |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:normalizedStringItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- Definition
+ References
+ Details
| Name: |
dei_EntityAddressCityOrTown |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:normalizedStringItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionCode for the postal or zip code
| Name: |
dei_EntityAddressPostalZipCode |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:normalizedStringItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionName of the state or province.
| Name: |
dei_EntityAddressStateOrProvince |
| Namespace Prefix: |
dei_ |
| Data Type: |
dei:stateOrProvinceItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionA unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b-2
| Name: |
dei_EntityCentralIndexKey |
| Namespace Prefix: |
dei_ |
| Data Type: |
dei:centralIndexKeyItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionIndicate if registrant meets the emerging growth company criteria. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b-2
| Name: |
dei_EntityEmergingGrowthCompany |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:booleanItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionCommission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.
| Name: |
dei_EntityFileNumber |
| Namespace Prefix: |
dei_ |
| Data Type: |
dei:fileNumberItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionTwo-character EDGAR code representing the state or country of incorporation.
| Name: |
dei_EntityIncorporationStateCountryCode |
| Namespace Prefix: |
dei_ |
| Data Type: |
dei:edgarStateCountryItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionThe exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b-2
| Name: |
dei_EntityRegistrantName |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:normalizedStringItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionThe Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b-2
| Name: |
dei_EntityTaxIdentificationNumber |
| Namespace Prefix: |
dei_ |
| Data Type: |
dei:employerIdItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionLocal phone number for entity.
| Name: |
dei_LocalPhoneNumber |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:normalizedStringItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionBoolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 13e
-Subsection 4c
| Name: |
dei_PreCommencementIssuerTenderOffer |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:booleanItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionBoolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 14d
-Subsection 2b
| Name: |
dei_PreCommencementTenderOffer |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:booleanItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionTitle of a 12(b) registered security. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b
| Name: |
dei_Security12bTitle |
| Namespace Prefix: |
dei_ |
| Data Type: |
dei:securityTitleItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionName of the Exchange on which a security is registered. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection d1-1
| Name: |
dei_SecurityExchangeName |
| Namespace Prefix: |
dei_ |
| Data Type: |
dei:edgarExchangeCodeItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionBoolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Section 14a
-Number 240
-Subsection 12
| Name: |
dei_SolicitingMaterial |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:booleanItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionTrading symbol of an instrument as listed on an exchange.
| Name: |
dei_TradingSymbol |
| Namespace Prefix: |
dei_ |
| Data Type: |
dei:tradingSymbolItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
| X |
- DefinitionBoolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act. Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Securities Act
-Number 230
-Section 425
| Name: |
dei_WrittenCommunications |
| Namespace Prefix: |
dei_ |
| Data Type: |
xbrli:booleanItemType |
| Balance Type: |
na |
| Period Type: |
duration |
|
Applied DNA Sciences (NASDAQ:APDN)
Historical Stock Chart
From Feb 2025 to Mar 2025
Applied DNA Sciences (NASDAQ:APDN)
Historical Stock Chart
From Mar 2024 to Mar 2025
