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RNS Number : 5353J

Silence Therapeutics PLC

03 April 2018

Litigation Update (Portugal and US)

London, 3(rd) April 2018

Silence Therapeutics plc, AIM:SLN ("the Company") a leader in the discovery, delivery, and development of novel RNA therapeutics for the treatment of serious diseases with unmet medical need, announces that, through Silence Therapeutics Gmbh (together "Silence"), it has yesterday brought patent infringement proceedings in Portugal against Alnylam's Patisiran product, and that on March 29(th) Alnylam Pharmaceuticals Inc. ("Alnylam") filed a Declaratory Judgement (DJ) against Silence Therapeutics plc and Silence Therapeutics Gmbh.

Regarding Portugal, Silence has previously stated that it is committed to defending its Intellectual Property (IP) and to secure the appropriate value for this IP it will act to enforce its patent estate as necessary. The next phase in the Portuguese legal process is that the Court will serve the claim on the defendant. The claim asks the Court to determine whether Patisiran infringes the Silence patent EP 1857547.

Regarding the US, Alnylam filed the Declaratory Judgment action in the U.S. federal district court in Boston, Massachusetts. The action seeks a finding of non-infringement of certain Silence patents. Silence's most recently-issued U.S. patents, such as those identified in Silence's updates dated August 15, 2017, October 11, 2017, and October 18, 2017, are not named in the lawsuit. The complaint has not yet been served on Silence. More information on the lawsuit can be found on the court's docket, at case number mad-1-18-cv-10613.

Ali Mortazavi, Chief Executive Officer of Silence Therapeutics plc, commented:

"We reiterate that we will defend the Silence patent estate where we consider third parties to be infringing the company's patent rights. As such, in Portugal we consider this process to be important in recognizing the contribution Silence has made to this field. Furthermore, we see Alnylam's filing of a DJ as an acknowledgment of the significance of our patent position."

Enquiries:

 
 Silence Therapeutics plc            Tel: +44 (0)20 3457 
  Ali Mortazavi, Chief Executive      6900 
  Officer 
  David Ellam, Chief Financial 
  Officer 
 
   Peel Hunt LLP (Nominated            Tel: +44 (0)20 7418 
   Adviser and Broker)                 8900 
   James Steel/Oliver Jackson 
 Media Enquiries: 
  Optimum Strategic Communications     Tel: +44 (0) 20 3714 
  Mary Clark/ Eva Haas/Hollie          1788 
  Vile 
  silence@optimumcomms.com 
 IR Enquires - US                    Tel: +1 (212) 213 
  Burns McClellan                     0006 
  John Grimaldi

Notes to Editors

About Silence Therapeutics plc

Silence Therapeutics develops a new generation of medicines by harnessing the body's natural mechanism of RNA interference, or RNAi, within its cells. Our proprietary technology can selectively inhibit any gene in the genome, specifically silencing the production of disease-causing proteins. Using our enabling delivery systems, we have achieved an additional level of specificity by delivering our therapeutic RNA molecules exclusively to target cells. Silence's proprietary RNA chemistries and delivery systems are designed to improve the stability of our molecules and enhance effective delivery to target cells, providing a powerful modular technology well suited to tackle life-threatening diseases. For more information, please visit: http://www.silence-therapeutics.com/

This information is provided by RNS

The company news service from the London Stock Exchange

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