ChemGenex to Present Pivotal Data in T315I Positive CML Patients as Oral Presentation at ASCO
May 14 2009 - 6:30PM
Business Wire
ChemGenex Pharmaceuticals Limited (ASX:CXS) (NASDAQ:CXSP)
announced today that updated clinical data from the
registration-directed clinical trial of omacetaxine will be
presented as an oral presentation at the forthcoming American
Society of Clinical Oncology (ASCO) 45th Annual Meeting in Orlando,
Florida.
Data from the pivotal study on the use of omacetaxine in chronic
myeloid leukemia (CML) patients who have failed imatinib and who
harbor the T315I mutation, will be given at 11:30 am on Monday 1st
June, by Dr. Jorge Cortes, MD, Professor of Medicine and Deputy
Chair in the Department of Leukemia at The University of Texas, MD
Anderson Cancer Center.
In addition, a poster on the company�s complementary phase 2
study investigating the potential use of omacetaxine in CML
patients with resistance to multiple tyrosine kinase inhibitors
(TKIs), will be presented between 5-6 pm on Friday 29th May by Dr.
Meir Wetzler MD, Chief of the Division of Leukemia, School of
Medicine and Biomedical Sciences, University at Buffalo, Roswell
Park Cancer Institute.
Commenting on today�s publication of the final program for ASCO,
Greg Collier, Ph.D., Managing Director and Chief Executive Officer
of ChemGenex said, �We are delighted that our late stage product
candidate, omacetaxine, will be presented at a podium session
during this prestigious conference.�
About Omacetaxine
Omacetaxine mepesuccinate is a first-in-class cetaxine with
demonstrated clinical activity as a single agent in a range of
hematological malignancies. Omacetaxine has a novel mechanism of
action, and induces apoptosis by inhibition of protein synthesis,
particularly Mcl-1. As omacetaxine acts independently of tyrosine
kinase inhibitors, it may have a therapeutic advantage for patients
who have developed resistance to TKIs. Omacetaxine is administered
subcutaneously.
About ChemGenex Pharmaceuticals Limited
(http://www.chemgenex.com)
ChemGenex Pharmaceuticals is a pharmaceutical development
company dedicated to improving the lives of patients by developing
personalized oncology medicines. ChemGenex harnesses the power of
genomics both to discover novel targets and drug compounds, and in
clinical trials to develop more individualized treatment outcomes.
ChemGenex�s lead compound, omacetaxine mepesuccinate, is currently
in phase 2/3 clinical trials for chronic myeloid leukemia (CML).
ChemGenex has a second anticancer compound, amonafide
dihydrochloride (Quinamed�) which is in phase 2 clinical
development for various solid cancers, and a portfolio of assets in
pre-clinical development. ChemGenex currently trades on the
Australian Stock Exchange under the symbol "CXS" and on NASDAQ
under the symbol "CXSP". For additional information on ChemGenex
Pharmaceuticals, please visit our web site at
http://www.chemgenex.com.
Details on the clinical trials can be accessed from the
following websites;
http://clinicaltrials.gov/ct2/show/NCT00375219?term=homoharringtonine&rank=9
and http://www.tkiresistantcmltrials.com
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