RNS Number:7620H
Profile Therapeutics PLC
20 February 2003


Letter to Profile Therapeutics plc


SECTION 198 COMPANIES ACT 1985

We, The Royal Bank of Scotland Group plc, on behalf of:

The Royal Bank of Scotland plc 

write to advise you pursuant to Section 198 of the Companies Act 1985 (the Act) 
that:

1.   This notification relates to the ordinary 2p share capital of Profile 
     Therapeutics plc.

2.   The number of shares of the person(s) with an interest for the purposes of 
     sections 208 and 209 of the Act, immediately after the time when the 
     obligation arose, are shown on the schedule below.

3.   The identity of the registered holder of these shares and the number of 
     shares held by the holder, so far as is known to us at the date of this 
     notification, are shown on the schedule below.

4.   The percentages quoted on the schedule below are based on your issued 
     ordinary share capital of 49,143,423, as advised to us by FT Information.

5.   None of the shares on the schedule below relates to interests as mentioned 
     in Section 208 (5) of the Act.

6.   The Royal Bank of Scotland Group plc, National Westminster Bank plc and 
     NatWest Ventures Investments Ltd continue to have an interest in 1,739,976 
     shares, but have not come under a further obligation to make a disclosure 
     as defined under Section 199 of the Act. This interest is included on the 
     schedule below.
 
Letter from The Royal Bank of Scotland Group


Schedule of registered holders for notification S198-L01/RJH/3014

Registered Holder                             Number of Shares       Percentage

NatWest Ventures Investments Ltd                     1,739,976      

Total interest of The Royal Bank of Scotland plc     1,739,976             3.54



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